Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients

December 2, 2009 updated by: Chungnam National University

Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma

A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.

Study Type

Observational

Enrollment (Actual)

1224

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Korea, Republic of
      • Daejeon, Korea, Republic of, 301-721
        • Chungnam National University Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

28 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

patients with open angle glaucoma who visited glaocoma clinic of departemtn of Ophtalmology, Chungnam National University Hospital, Daejeon, south Korea

Description

Inclusion Criteria:

  • Clinical diagnosis of primary open angle glaucoma

Exclusion Criteria:

  • Primary open angle glaucoma combined with congenital ocular disease
  • Primary open angel glaucoma combined with other ocular disease
  • Significant systemic disease other than systemic hypertension and diabetes

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Case-Control
  • Time Perspectives: Prospective

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
POAG group
Elevated intraocular pressure normal open angle glaucomatous optic nerve head abnormality glaucomatous visual field defect
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Normal control
Normal intraocular pressure No optic disc abnormality No visual field defect No significant ocular and systemic disease
Genetic: SNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
genotyping for the SNP associated with primary open angle glaucoma
Time Frame: one year
one year

Secondary Outcome Measures

Outcome Measure
Time Frame
genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns
Time Frame: one year
one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chungnam National University

Collaborators

Korea Healthcare Technology R&D Project
Korea Advanced Institute of Science and Technology

Investigators

  • Principal Investigator: Chang-sik Kim, professor, Department of Ophthalmology, Chungnam National University Hospital
  • Study Chair: Changwon Kang, professor, Korea Advanced Institute of Science and Technology
  • Study Director: Kyunglan Kim, Department of Biological Sciences, Korea Advanced Institute of Science and Technology

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2007

Primary Completion (Actual)

October 1, 2009

Study Completion (Actual)

November 1, 2009

Study Registration Dates

First Submitted

December 2, 2009

First Submitted That Met QC Criteria

December 2, 2009

First Posted (Estimate)

December 3, 2009

Study Record Updates

Last Update Posted (Estimate)

December 3, 2009

Last Update Submitted That Met QC Criteria

December 2, 2009

Last Verified

December 1, 2009

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CNUH81510-886
  • A080587 (Other Grant/Funding Number: Korea Healthcare Technology R&D Project)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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