Effect of High-intensity Intermittent Sprinting on Appetite Control on Obese Volunteers

February 5, 2015 updated by: Norwegian University of Science and Technology

Acute Effects of High-intensity Intermittent Sprinting vs. Moderate Intensity Continuous Cycling on Appetite Control on Obese Volunteers

Several studies have shown that high intensity intermittent sprints (HIIS) are more effective than moderate intensity continuous cycling (MICC) in reducing fat mass and improving insulin resistance in normal weight individuals. Changes in the appetite-regulatory system in response to exercise are likely to explain, at least partially, the better outcome observed after HIIS. Unfortunately, there are no studies comparing the impact of different types of acute aerobic exercise on the release of appetite-regulating hormones, subjective feelings of appetite and subsequent energy intake (EI).

The primary objective of this study is to investigate the effects of acute isocaloric bouts of HIIT and MICC or a short duration sprint, in comparison with a resting control condition, on the postprandial release of appetite-regulating hormones, subjective feelings of appetite and subsequent EI in obese individuals. The investigators hypothesize that an isocaloric session of HIIS will result in a better short-term appetite control compared with MICC, by reducing hunger feelings and subsequent food intake more than MICC and by inducing a larger increase in the release of satiety gut peptides compared with the MICC.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This will be a randomised cross-over study with four legs. Participants will act as their own controls and will be assigned to the four experimental conditions (resting, HIIS, MICC and SDS), 1 week apart, in a counter-balanced order.

Participants will be asked to come to the Unit five times: one preliminary session and four experimental conditions (resting, HIIS and MICC isocaloric sessions and SDS). In the preliminary session, anthropometric data (weight and height) will be collected and a maximal fitness test performed, using a cycle ergometer.

For the four experimental conditions, participants will be asked to arrive at approximately 8.00, having fasted for at least 10 hours, and a cannula will be inserted into an antecubital vein. Two fasting blood samples will be taken and a standard breakfast offered. After that, serial blood samples will be taken at regular intervals for a period of 3h.

Participants will be asked to rate their subjective feelings of hunger and fullness using visual analogue scales (VAS) throughout each study morning at different time points. Three hours after breakfast, participants will be placed in individual rooms, presented with a standardized lunch and instructed to rate the taste and palatability of the food presented.

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Norway
      • Trondheim, Norway, 7489
        • Norwegian University of Science and Technology

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 50 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • an inactive lifestyle,
  • weight stable on the previous 3 months,
  • not currently dieting to loose weight
  • restraint score derived from the Three Factor Eating Behaviour Questionnaire ≤12

Exclusion Criteria:

  • history of coronary heart disease,
  • type 1 or type 2 diabetes,
  • anaemia,
  • gout,
  • depression or other psychological disorders,
  • eating disorders,
  • drug or alcohol abuse within the last two years,
  • current medication known to affect appetite or induce weight loss and hypertension.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Resting - control
No exercise
Behavioral: resting - control
Experimental: Moderate intensity exercise
Moderate intensity exercise (continuous) 1h after breakfast
Behavioral: Moderate intensity exercise
Experimental: High intensity intermittent training
High intensity intermittent training 1h after breakfast
Behavioral: High intensity intermittent training
Experimental: Short sprint
Short sprint 1h after breakfast
Behavioral: Short sprint

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Changes in gut peptides
Time Frame: Blood samples taken in fasting and postprandially for 3h
Blood samples taken in fasting and postprandially for 3h

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Food intake at test meal
Time Frame: 3h after breakfast
Food intake at a test meal will be assessed 3h after breakfast (at 180 minutes)
3h after breakfast

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Norwegian University of Science and Technology

Collaborators

Helse Midt-Norge

Investigators

  • Principal Investigator: Catia Martins, PhD, Norwegian University of Science and Technology

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2010

Primary Completion (Actual)

December 1, 2012

Study Completion (Actual)

June 1, 2014

Study Registration Dates

First Submitted

June 2, 2010

First Submitted That Met QC Criteria

June 11, 2010

First Posted (Estimate)

June 14, 2010

Study Record Updates

Last Update Posted (Estimate)

February 6, 2015

Last Update Submitted That Met QC Criteria

February 5, 2015

Last Verified

February 1, 2015

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2010/444-7

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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