- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01269970
Early Metabolic Response in Locally Advanced Esophageal Cancer Undergoing Induction Chemoradiotherapy
January 3, 2011 updated by: Universitaire Ziekenhuizen KU Leuven
Early Metabolic Response Evaluation With 18-FDG PET-CT in Esophageal Cancer Treated With Neoadjuvant Chemoradiotherapy Followed by Esophagectomy
Early metabolic response evaluation may predict clinical and histopathological response after neoadjuvant chemotherapy.
Its value in neoadjuvant chemoradiotherapy (CRT) is unknown.
Our aim was to assess the value of early metabolic response after one cycle of chemotherapy using 18-FDG-PET-CT to predict pathological response and outcome in cT2-4 N0/+ esophageal cancer treated by neoadjuvant CRT and esophagectomy.
Study Overview
Status
Completed
Intervention / Treatment
Study Type
Observational
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Vlaams-Brabant
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Leuven, Vlaams-Brabant, Belgium, 3000
- UZLeuven
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Probability Sample
Study Population
locally advanced esophageal cancer (cT2-4 N0/+) of the esophagus (n=42) and GEJ (n=13)
Description
Inclusion Criteria:
- locally advanced esophageal cancer (cT2-4 N0/+)
Exclusion Criteria:
- PET-CT not performed at UZLeuven
- Other tumor types
- Distant metastases (organ)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
locally advanced esophageal carcinoma (cT2-3N0/+)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
---|---|
early metabolic response to predict pathological response and outcome
|
assess the value of early metabolic response with 18-FDG-PET-CT (i.e. a decrease of ≥ 35% of SUVmean) after a single cycle of chemotherapy followed by neoadjuvant CRT and esophagectomy as a tool to predict pathological response and outcome in patients with cT2-4N0/+ carcinoma of the esophagus and GE-junction (GEJ).
|
Secondary Outcome Measures
Outcome Measure |
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to study correlations between early metabolic response, late metabolic response, histopathological response and outcome.
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
January 1, 2004
Primary Completion (Actual)
July 1, 2008
Study Completion (Actual)
December 1, 2009
Study Registration Dates
First Submitted
January 3, 2011
First Submitted That Met QC Criteria
January 3, 2011
First Posted (Estimate)
January 4, 2011
Study Record Updates
Last Update Posted (Estimate)
January 4, 2011
Last Update Submitted That Met QC Criteria
January 3, 2011
Last Verified
January 1, 2011
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- G.0175.03
- S24640 (Registry Identifier: clinical trial center UZLeuven)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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