- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01355510
Effects of Electrical Baroreflex Stimulation on Sympathetic Activity, Renal Hemodynamics, and Insulin Sensitivity (CVRX-ReSy)
Electrical Baroreflex Stimulation - Sympathetic Activity
Electrical stimulation of carotid baroreceptors (baropacing) acutely decreases arterial pressure in patients with refractory hypertension. The reduction in blood pressure seems to be mediated through sympathetic inhibition with concomitant reduction in the activity of the renin-angiotensin system. Indeed, switching on and off the stimulation is accompanied by decreases and increases in central sympathetic vasoconstrictor outflow, respectively. Plasma renin concentration also decreases with acute electrical baroreflex stimulation.
In some patients chronic baropacing is associated with long-term blood pressure reduction.
However, there is sparse information as to the relative contribution of blood pressure regulating systems to account for the acute and chronic effects of baropacing. Sympathetic, renal, and vascular mechanisms are of special interest. Furthermore, technical aspects of electrical baroreflex stimulation may play a role, e.g. worsening of the electrical contact between the stimulating electrodes and the baroreceptor afferents.
This study is designed to answer the following primary questions:
- Does chronic electrical stimulation of carotid baroreceptors inhibit sympathetic vasoconstrictor tone also in the long-term?
- Does sympathetic vasoconstrictor tone increase on switching off chronic baropacing? Such an increase would confirm electrical integrity of the system and proper contact to the baroreceptor afferents.
- Does acute electrical baroreflex stimulation decrease renal vascular resistance?
- Does acute electrical baroreflex stimulation influence glucose delivery to skeletal muscle and change insulin sensitivity? The study follows an open-label observational design and it is planned to recruit up to 30 patients over 3 years.
Study Overview
Status
Conditions
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Jordan Jens, MD
- Phone Number: +495115322821
- Email: jordan.jens@mh-hannover.de
Study Locations
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Hannover, Germany
- Recruiting
- Hannover Medical School
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Contact:
- Jens Jordan, MD
- Phone Number: +495115322821
- Email: jordan.jens@mh-hannover.de
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Principal Investigator:
- Jens Jordan, MD
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Sub-Investigator:
- Karsten Heusser, MD
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Subjects meeting all of the following criteria will be considered for enrollment in the study:
- Adult patients having an implanted device for electrical baroreflex stimulation.
- Signed written informed consent.
Exclusion Criteria:
Subjects meeting all of the following criteria will be excluded from the study:
ReSy Study - Protocol version: December 20, 2010 8
- Subject is the investigator or any sub-investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the protocol.
- Mental condition rendering the subject unable to understand the nature, scope, and possible consequences of the study.
- Subject unlikely to comply with protocol, e. g. uncooperative attitude, inability to return for follow-up visits, and unlikelihood of completing the study.
- Pregnancy. Breast-feeding.
- History of hypersensitivity to inulin or paraaminohippurate or to drugs with a similar chemical structure have to be excluded from the constant-infusion procedure.
- History of drug or alcohol abuse.
- Blood donation of more than 500 mL during the previous 3 months (men) or 6 months (women).
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- DE-MHH-CVRX-ReSy-EK5753
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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