- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01718262
Study Measuring Total Plasma Ropivacaine Levels During Continuous Peripheral Nerve Catheter Infusion
August 9, 2019 updated by: Defense and Veterans Center for Integrative Pain Management
The purpose of the study is to measure the blood levels of the medicine called ropivacaine (local anesthetic) used to manage pain.
Ropivacaine is a widely used medication and is not the subject of this study, but the investigators are studying how much of the drug can be found in the patient's blood, known as the blood level, of this medicine.
Too much ropivacaine in a patient's blood can lead to local anesthetic toxicity.
Once the nerve catheter is removed, local anesthetic toxicity is no longer a potential problem.
However, there is little data on what ropivacaine blood levels are after having the catheter in for a long period of time(up to one month).
Study Overview
Status
Completed
Conditions
Study Type
Observational
Enrollment (Actual)
49
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Maryland
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Bethesda, Maryland, United States, 20889
- Walter Reed National Military Medical Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 89 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Military health care beneficiaries age 18 years and older presenting for upper or lower extremity surgery requiring continuous infusions of local anesthetic either at WRNMMC will be asked to participate in the study.
We will recruit up to fifty patients for the study at WRNMMC.
Description
Inclusion Criteria:
- Males and females 18 years and older, capable of providing informed consent indicating awareness of the investigational nature of the study, in keeping with institutional policy
- Written informed consent must be obtained from each patient prior to entering the study
- Patients must be scheduled to receive a continuous peripheral nerve catheter
Exclusion Criteria:
- Refusal to have serial blood drawn
- Contraindication for a continuous peripheral nerve catheter (allergy to local anesthetic, infection at site of injection, elevated coagulation times (international normalized ratio (INR)>1.5, partial thromboplastin time (PTT)>38; these values are drawn as part of routine standard of care and those values will be checked prior to initial catheter insertion), therapeutic dosing of anticoagulation medication, moderate to severe head injury and moderate to severe traumatic brain injury
- Patients with a hematocrit < 20. Complete Blood Counts (CBCs) are drawn as part of routine standard of care and will be followed by the Acute Pain Service. Although the CBCs and ropivacaine blood draws will not always coincide, we will always check the last hematocrit obtained prior to our blood draw
- Severe liver or renal disease (values greater than two times normal range)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Plasma Ropivicaine Levels
Time Frame: up to 10 days
|
Blood will be drawn every 0, 3, 5, 7, and 10 days.
Blood is drawn every 3 days thereafter.
|
up to 10 days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
April 1, 2010
Primary Completion (Actual)
November 1, 2011
Study Completion (Actual)
November 1, 2011
Study Registration Dates
First Submitted
October 17, 2012
First Submitted That Met QC Criteria
October 29, 2012
First Posted (Estimate)
October 31, 2012
Study Record Updates
Last Update Posted (Actual)
August 12, 2019
Last Update Submitted That Met QC Criteria
August 9, 2019
Last Verified
August 1, 2019
More Information
Terms related to this study
Other Study ID Numbers
- 353368-19
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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