- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01723891
Study To Compare Safety and Pharmacokinetic Properties of Surfolase Capsule and HT-002-01 in Healthy Male Volunteers
November 7, 2012 updated by: Hyundai Pharmaceutical Co., LTD.
Study to compare safety and pharmacokinetic properties of surfolase capsule and HT-002-01 after oral administration for one day in healthy male volunteer.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
24
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Seoul, Korea, Republic of, 120-752
- Yonsei University Health System, Severance Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 55 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- healthy male subjects between the age of 20 and 55 years with body mass index between 18.5 and 25
- Volunteers without apriority of chronic disease
- Volunteers must be in good health as determined by the investigator based on a detailed medical history, full physical examination, electrocardiogram, laboratory tests and urinalysis
- Volunteers who comply with the protocol, understand and sign an informed consent
Exclusion Criteria:
- Sensitive response to acebrophylline and xanthine
- Galactose intolerance, Lapp lactase deficiency and Glucose-Galactose Malabsorption
- Known history of renal, hepatic, respiratory, neurologic, endocrine, cardiac vascular and hematopoietic disease, especially gallstone
- Known history of gastrointestinal disease which affects the absorption of medicine.
- Excluded by screening tests
- Upper limit of AST, ALT>1.25 times Upper limit of total bilirubin>1.5 times
- Estimated GFR<80mL/min/1.73m2)
- systolic blood pressure < 90 or > 150, diastolic blood pressure <50 or >100
- Known history of drug abuse
- caffeine>5cups/day, alcohol>210g/week, 10 more cigarettes/day
- Use of any prescription drug within 14days or over-the-counter (OTC) medication within 7 days prior to dosing
- Participation in any clinical investigation within 60 days prior to study start
- Donation of blood within 60 days, donation of component blood within 30days
- Judged by the investigators to be undesirable as subjects
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Surfolase capsule & HT-002-01
|
|
Active Comparator: HT-002-01 & Surfolase capsule
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
---|
AUCt, Cmax
|
Secondary Outcome Measures
Outcome Measure |
---|
AUCinf, Tmax, t1/2
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2012
Study Registration Dates
First Submitted
November 6, 2012
First Submitted That Met QC Criteria
November 7, 2012
First Posted (Estimate)
November 8, 2012
Study Record Updates
Last Update Posted (Estimate)
November 8, 2012
Last Update Submitted That Met QC Criteria
November 7, 2012
Last Verified
November 1, 2012
More Information
Terms related to this study
Other Study ID Numbers
- HT-002-01
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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