Induction of Immunity Against Measles in Pediatric Liver Transplant Recipients (MMRinOLT)

September 16, 2020 updated by: Klara M. Pósfay Barbe

Induction and Maintenance of Immunity Against Measles in Pediatric Orthotopic Liver Transplantation Recipients: a Prospective Nationwide Study in Switzerland

Measles is a vaccine-preventable disease, which can be life-threatening in immunosuppressed children. Currently, measles vaccine is not recommended in pediatric orthotopic liver transplant recipients, because it is a live-attenuated vaccine.

We want to assess the influence of immunosuppression on immunity against measles in previously vaccinated children and to evaluate the induction of B cell and T cell response against measles elicited by vaccination in children at least 12 months after transplantation.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Detailed Description

Eligible children in Group 2 will receive a standard dose (0.5 ml) of MMR vaccine during the first medical visit (V1). The lot number and the expiration date will both be recorded on the patient's case report form (CRF). A serological evaluation 4-8 weeks after MMR will identify children requiring an additional dose given 1-2 months apart, as currently recommended for subjects 1 year-old or with limited immune competence (i.e. HIV-infected children). Serological evaluation 4-8 weeks after the second dose or at the one-year follow-up will identify eventual non-responder requiring a third dose. Three will be the maximal number of administrated dose according to this protocol. The persistence of measles-specific antibodies will be assessed yearly, when patients come for their routine visit to the transplant center.

Children who do not need MMR immunization because of protective levels will be monitored yearly for maintenance of antibody levels during routine yearly visits/ blood samplings and will not have further intervention.

Study Type

Interventional

Enrollment (Anticipated)

90

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Switzerland
    • GE
      • Geneva, GE, Switzerland, 1211
        • Recruiting
        • Children's Hospital of Geneva
        • Principal Investigator:
          • Klara M Posfay-Barbe, MD, MS
        • Contact:
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 year to 20 years (Child, Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Age ≥ 12 months
  • Measles-specific IgG antibodies negative (<0.2 IU/L), as detected by the routine ELISA assay
  • ≥ 12 months from the time of transplantation and ≥ 2 months from the time of an acute rejection episode
  • Steroids < 2 mg/kg/day, tacrolimus < 0.3mg/kg/day and tacrolimus level < 8 ng/ml for > 1 month.
  • Total lymphocyte count ≥ 750 cells/ul at time of immunization

Exclusion Criteria:

  • Known wild-type measles exposure during the last four weeks
  • Measles-containing immunoglobulins administered within the 5 months preceding the measles vaccine. If the child receives measles-containing Ig before an additional dose of MMR vaccine, he/she will be withdrawn from the study
  • Antiviral agents administered during the last four weeks
  • Febrile illness (>38.5°) in the 72 hours before vaccine administration
  • Chronic aspirin therapy
  • Any other immunization with a live-attenuated vaccine during the last four weeks
  • Pregnancy

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: MMR vaccination
MMR vaccine to seronegative pediatric SOT recipients
Biological: MMR vaccination
Unprotected children will be vaccinated with two MMR vaccines

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
serologic response to MMR vaccine in seronegative transplant recipients
Time Frame: 2 months after vaccination
Pediatric transplant recipients will be vaccinated with MMR vaccine (previously seronegative) and their seroresponse will be measured 2 months later
2 months after vaccination

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Persistance of seroresponse to MMR vaccine
Time Frame: 3 years
Seroresponse to MMR vaccine will be followed over time in pediatric transplant recipients
3 years

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Efficacy of MMR vaccine in pediatric SOT recipients
Time Frame: 3 years
Protection against vaccine-preventable diseases will be assessed in pediatric SOT recipients
3 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Klara M. Pósfay Barbe

Collaborators

University Hospital, Geneva

Investigators

  • Principal Investigator: Klara M Posfay-Barbe, MD, MS, University Hospitals of Geneva

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2013

Primary Completion (Anticipated)

April 1, 2022

Study Completion (Anticipated)

October 1, 2025

Study Registration Dates

First Submitted

January 15, 2013

First Submitted That Met QC Criteria

January 15, 2013

First Posted (Estimate)

January 17, 2013

Study Record Updates

Last Update Posted (Actual)

September 18, 2020

Last Update Submitted That Met QC Criteria

September 16, 2020

Last Verified

September 1, 2020

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MMR in pediatric OLT
  • 12-226 (MatPed 12-048) (Other Identifier: IRB)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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