Plethysmography Opto-electronic and Asthma

Analysis of the Distribution of Pulmonary Ventilation After Nebulization by Heliox Associated With Positive Expiratory Pressure in Patients Asthmatics Stable.

Sponsors

Lead Sponsor: Universidade Federal de Pernambuco

Source Universidade Federal de Pernambuco
Brief Summary

Objective: To assess the influence of nebulization with bronchodilators carried by the heliox coupled to PEP in the distribution of compartimental lung volumes in asmathic adults and to correlate with pulmonary function data. Methods: A controlled randomized trial involving 27 patients divided into four groups: heliox + PEP, oxygen + PEP, heliox and oxygen. After the initial evaluation, it was placing 89 reflective markers attached to the surface of the trunk and images acquired by optoelectronic plethysmography (OEP) of six cameras. Three slow vital capacity maneuvers and quiet breathing regarded as phase control. After the control phase, all patients underwent nebulization with a distribution noninvasive system, semi-closed using 10 drops of Fenoterol Bromide and 20 drops of Ipratropium.

Overall Status Completed
Start Date June 2009
Completion Date November 2009
Primary Completion Date June 2009
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
Distribution of volumes of the rib cage in asthma patients-Plesthysmography opto - electronic (POE). 5 months
Secondary Outcome
Measure Time Frame
Lung function in asthmatic subjects 5 mothns
Enrollment 27
Condition
Intervention

Intervention Type: Other

Intervention Name: Oxygen

Description: For inhalation of oxygen, we used a noninvasive delivery system, semi - closed (Figure 3) consisting of a non-toxic face mask with two unidirectional valves - inspiratory and expiratory branch - connected to the nebulizer (Airlife Misty Neb, Baxter; Valencia, CA, USA). In the inspiratory branch, a reservoir bag (Hudson RCI, USA) with capacity of 2.5 L was connected, in order to avoid dilution of the gas. This skin was fixed to the patient's face to prevent leakage and to maintain adequate pressurization and improved patient compliance to the PEEP. The nebulizer was fed by a flow of 8 l / min of oxygen.

Intervention Type: Other

Intervention Name: Heliox

Description: For inhalation of heliox, we used a noninvasive delivery system, semi - closed consisting of a non-toxic face mask with two unidirectional valves - inspiratory and expiratory branch - connected to the nebulizer (Airlife Misty Neb, Baxter; Valencia, CA, USA). In the inspiratory branch, a reservoir bag (Hudson RCI, USA) with capacity of 2.5 L was connected, in order to avoid dilution of the gas. This skin was fixed to the patient's face to prevent leakage and to maintain adequate pressurization and improved patient compliance to the PEEP. The nebulizer was fed by a 11 l / min of heliox for the heliox group in accordance with a protocol of Hess et al.

Intervention Type: Other

Intervention Name: PEEP

Description: PEEP supplied was 10 cm H2O through valve (Vital Signs,Totowa, USA) attached to the expiratory branch.

Eligibility

Criteria:

Inclusion Criteria:

- The study included individuals diagnosed with moderate to severe asthma with forced expiratory volume in one second (FEV1) <60% or FEV1 <60% - 80% predicted;

- showing reversibility of bronchial obstruction after administration of bronchodilators at least 10% in FEV1.

Exclusion Criteria:

- unable to understand or perform the spirometric maneuver;

- with a history of smoking;

- pulmonary comorbidities as chronic obstructive pulmonary disease (COPD);

- bronchiectasis and tuberculosis sequel;

- hemodynamic instability defined as heart rate (HR) greater than 150 bpm or systolic blood pressure below 90 mmHg or greater than 150mmHg;

- pregnancy and any contraindication to the use of PEEP;

- such as increased work of breathing (acute asthma);

- active hemoptysis;

- acute sinusitis;

- pneumothorax;

- untreated; surgery or facial trauma;

- oral or injury;

- epistaxis;

- nausea and esophageal surgery.

Gender: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Healthy Volunteers: No

Location
Facility: Laboratório de Fisiologia e Fisioterapia cardiorespiratória
Location Countries

Brazil

Verification Date

December 2012

Responsible Party

Type: Principal Investigator

Investigator Affiliation: Universidade Federal de Pernambuco

Investigator Full Name: Daniella Cunha Brandao

Investigator Title: PhD

Has Expanded Access No
Condition Browse
Number Of Arms 4
Arm Group

Label: Oxygen

Type: Placebo Comparator

Label: PEEP + Heliox

Type: Experimental

Label: Oxygen + PEEP

Type: Experimental

Label: Heliox

Type: Active Comparator

Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: Double (Participant, Investigator)

Source: ClinicalTrials.gov