Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill

January 13, 2014 updated by: Xiaohua Qiu, Zhongda Hospital
Compared with AN69 hemofilter, AN69 ST hemofilter may prolong the time of hemofilter and decrease the quantity of heparin during continuous renal replacement therapy in critically ill.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

40

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Jiangsu
      • Nanjing, Jiangsu, China, 210009
        • Recruiting
        • Xiaohua Qiu
        • Contact:
        • Principal Investigator:
          • Qiu Xiaohua

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 90 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • age> 18 years old
  • admitted to ICU and need CRRT
  • anticipated survival time >72h

Exclusion Criteria:

  • allergy to hemofilter or heparin
  • heparin associated thrombocytopenia
  • pregnancy or lactation
  • using other anticoagulate drugs

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: AN 69 ST hemofilter
Use AN 69 ST hemofilter during CRRT
Device: AN 69 ST hemofilter
ACTIVE_COMPARATOR: AN 69 hemofilter
Use AN 69 hemofilter during CRRT
Device: AN 69 hemofilter

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The using time of hemofilters
Time Frame: 72h
The time from the beginning of continuous renal replacement therapy until to the end when continuous renal replacement therapy had to be finished because of clotting or other reasons
72h

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
activated partial thromboplastin time
Time Frame: every 6h from the begining of continuous renal replacement therapy,up to 72h
Heparin will be used according to activated partial thromboplastin time, and the quantity will be recorded.
every 6h from the begining of continuous renal replacement therapy,up to 72h

Other Outcome Measures

Outcome Measure
Time Frame
Number of participants with adverse events during continuous renal replacement therapy
Time Frame: 72h
72h

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhongda Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2012

Primary Completion (ANTICIPATED)

May 1, 2014

Study Registration Dates

First Submitted

March 19, 2013

First Submitted That Met QC Criteria

March 29, 2013

First Posted (ESTIMATE)

April 4, 2013

Study Record Updates

Last Update Posted (ESTIMATE)

January 15, 2014

Last Update Submitted That Met QC Criteria

January 13, 2014

Last Verified

January 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 112233

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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