Influence of Consecutive Strength- and Endurance Regimes on the Myonuclear Domain and Satellite Cell in the M. Vastus Lateralis of Old Healthy Men

Randomised training intervention.

Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell

Sarcopenia

Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible.

Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.

Study Overview

• Status: Completed
• Conditions: Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation
• Intervention / Treatment: Procedure: Training

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Switzerland
  • ZH
    • Zurich, ZH, Switzerland, 8091
      • University Hospital Zurich, Division of Neurology

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion criteria: -male

• no fever at the beginning and during the study
• between 60 years and 75 years
• non smokers
• no known cardiovascular and orthopaedic problems
• no cardiac pacemaker
• fulfilling the health criteria

Exclusion criteria: -female

• fever or cold at the beginning or during the study
• non MRI compatible metal implants
• under 60 years or over 75 years
• smoker
• cardiovascular or orthopaedic problems
• cardiac pacemaker
• not fulfilling the health criteria

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Endurance and Resistance Training; Endurance and resistance exercise	Procedure: Training
Experimental: Resistance Training; resistance exercise (12wk)	Procedure: Training
Experimental: Resistance and resistance Training; resistance exercise (24 wk)	Procedure: Training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes	Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes	participants will be followed for the duration of training period, an expected average of 7 months

Collaborators and Investigators

• Sponsor: University of Zurich

Study record dates

Study Major Dates

• Study Start: August 1, 2013
• Primary Completion (Actual): December 1, 2015
• Study Completion (Actual): August 1, 2017

Study Registration Dates

• First Submitted: July 16, 2013
• First Submitted That Met QC Criteria: July 18, 2013
• First Posted (Estimate): July 23, 2013

Study Record Updates

• Last Update Posted (Actual): August 7, 2017
• Last Update Submitted That Met QC Criteria: August 4, 2017
• Last Verified: August 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: REGPOT