- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02109393
Rehabilitation in Patients With Progressive Supranuclear Palsy (PSP-MIRTLoko)
Rehabilitation in Patients With Progressive Supranuclear Palsy: Effectiveness of Two Intensive Protocols
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Como
-
Gravedona, Como, Italy, 22015
- Ospedale Generale di Zona "Moriggia-Pelascini"
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
a) diagnosis of PSP in accordance to the NINDS-SPSP International Criteria (Litvan et al., 1996), b) age between 55 and 85 c) ability to walk unassisted for at least 6 meters, d) stable dopaminergic drugs dosage in the month preceding the admission to the study
Exclusion Criteria:
a) any others significant neurological or orthopedic disorders, b) osteoarthritis, osteoporosis, cutaneous lesions and/or other pressure wounds, c) body weight exceeding 135 kg (the weight limit for the use of Lokomat®), respiratory and cardiovascular diseases.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: MIRT group
This group underwent a 4-weeks MIRT exploiting the use of a treadmill-plus (treadmill associated with visual cues and auditory feedbacks). Inclusion criteria: a) diagnosis of idiopathic PSP in accordance to the NINDS-SPSP International Criteria (Litvan et al., 1996), b) age between 55 and 85 c) ability to walk unassisted for at least 6 meters, d) stable dopaminergic drugs dosage in the month preceding the admission to the study. Exclusion criteria: a) any others significant neurological or orthopedic disorders, b) osteoarthritis, osteoporosis, cutaneous lesions and/or other pressure wounds, c) body weight exceeding 135 kg (the weight limit for the use of Lokomat®), respiratory and cardiovascular diseases. |
It consists of a 4-weeks physical therapy which entails four daily sessions for five days. All treatments are performed in aerobic condition. The duration of each session, including recovery periods, is about one hour. The first session consists of a one-to-one session with physical therapist. The second session includes aerobic and repetitive exercises to improve balance and gait using different devices: a posturographic platform with visual cues, cycloergometer, treadmill-plus. The third is a session of occupational therapy. The last session includes one hour of speech therapy. All patients undergo 20-minutes treadmill-plus training per day, 5 times a week, for 4 weeks. |
Experimental: MIRT+Lokomat group
This group underwent a 4-weeks MIRT involving the use of Lokomat® for 5 days per week in spite of treadmill-plus. Inclusion criteria: a) diagnosis of idiopathic PSP in accordance to the NINDS-SPSP International Criteria (Litvan et al., 1996), b) age between 55 and 85 c) ability to walk unassisted for at least 6 meters, d) stable dopaminergic drugs dosage in the month preceding the admission to the study. Exclusion criteria: a) any others significant neurological or orthopedic disorders, b) osteoarthritis, osteoporosis, cutaneous lesions and/or other pressure wounds, c) body weight exceeding 135 kg (the weight limit for the use of Lokomat®), respiratory and cardiovascular diseases. |
It consists of a 4-weeks physical therapy which entails four daily sessions for five days.
All treatments are performed in aerobic condition.
The duration of each session, including recovery periods, is about one hour.
The first session consists of a one-to-one session with physical therapist.
The second session includes aerobic and repetitive exercises to improve balance and gait using different devices: a posturographic platform with visual cues and cycloergometer.
The third is a session of occupational therapy to improve autonomy in activities of daily life.
The last session includes one hour of speech therapy.
All patients undergo 20-minutes Lokomat® training per day in spite of treadmill-plus.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
PSPRS
Time Frame: One month
|
PSP Rating Scale
|
One month
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
BBS
Time Frame: One month
|
Berg Balance Scale
|
One month
|
NoF
Time Frame: One month
|
Number of falls
|
One month
|
Collaborators and Investigators
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PSP-MIRTLoko
- PSP MIRT-Loko 001 (Other Identifier: Ospedale Generale di Zona "Moriggia-Pelascini")
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Progressive Supranuclear Palsy
-
Novartis PharmaceuticalsActive, not recruitingProgressive Supranuclear Palsy (PSP)Germany, United Kingdom, Canada, United States
-
AbbVieTerminatedProgressive Supranuclear Palsy (PSP)United States, Australia, Canada, Italy, Japan
-
AbbVieCompletedProgressive Supranuclear Palsy (PSP)United States
-
Assistance Publique Hopitaux De MarseilleCompletedProgressive Supranuclear Palsy (PSP)France
-
Oregon Health and Science UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaboratorsRecruitingSupranuclear Palsy, Progressive | Palsy SupranuclearUnited States
-
University of California, San FranciscoNational Institutes of Health (NIH); National Institute on Aging (NIA)Active, not recruitingProgressive Supranuclear Palsy (PSP) | Corticobasal Degeneration (CBD) | Nonfluent Variant Primary Progressive Aphasia (nfvPPA) | Corticobasal Syndrome (CBS) | Cortical-basal Ganglionic Degeneration (CBGD) | Oligosymptomatic/Variant Progressive Supranuclear Palsy (o/vPSP)United States, Canada
-
University of California, San FranciscoTau Consortium; CBD SolutionsCompletedProgressive Supranuclear Palsy (PSP) | Corticobasal Degeneration (CBD) | Corticobasal Syndrome (CBS) | Primary Four Repeat Tauopathies (4RT)United States
-
UCB Biopharma SRLCompletedProgressive Supranuclear PalsyBelgium, Germany, Spain, United Kingdom
-
Centre Hospitalier Universitaire de Pointe-a-PitreGroupe Hospitalier Pitie-Salpetriere; University Hospital Center of MartiniqueCompletedProgressive Supranuclear Palsy
-
University of LouisvilleCompletedProgressive Supranuclear PalsyUnited States
Clinical Trials on MIRT
-
Ospedale Generale Di Zona Moriggia-PelasciniCompletedParkinson Disease | Gait Disorders, Neurologic | Gait Disorder, SensorimotorItaly
-
Ospedale Generale Di Zona Moriggia-PelasciniCompleted
-
Ospedale Generale Di Zona Moriggia-PelasciniUnknownRehabilitation | PD | Gait Dysfunction, NeurologicItaly
-
Ospedale Generale Di Zona Moriggia-PelasciniUnknownParkinson DiseaseItaly
-
Ospedale Generale Di Zona Moriggia-PelasciniCompletedParkinson's DiseaseItaly
-
Ospedale Generale Di Zona Moriggia-PelasciniCompletedParkinson's DiseaseItaly
-
Ospedale Generale Di Zona Moriggia-PelasciniCompletedParkinson Disease | Rehabilitation | Dexterity
-
Ospedale Generale Di Zona Moriggia-PelasciniCompleted
-
Ospedale Generale Di Zona Moriggia-PelasciniCompleted
-
Ospedale Generale Di Zona Moriggia-PelasciniCompletedParkinson Disease and Pisa SyndromeItaly