Volatile Versus Propofol Anesthesia in OPCAB

August 20, 2014 updated by: Jong Hwan Lee, Samsung Medical Center

Comparison of Propofol and Isoflurane Anesthesia on Cardioprotection and Clinical Outcomes in Patients Undergoing Off-pump Coronary Artery Bypass Graft Surgery : A Propensity-score Analysis

Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.

Study Type

Observational

Enrollment (Actual)

1080

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

patients underwent OPCAB from January, 2010 to December, 2012

Description

Inclusion Criteria:

  • OPCAB

Exclusion Criteria:

  • On pump conversion

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Isoflurane group
Isoflurane inhalational anesthesia during OPCAB
Drug: Isoflurane
Comparison between isoflurane and propofol, Retrospective study
Other Names:
  • inhalational anesthetics
Propofol group
Total intravenous anesthesia with propofol during OPCAB

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
CK-MB, CRP
Time Frame: Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2
Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2
Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Clinical adverse outcomes
Time Frame: until 1 year after OPCAB
clinical adverse outcomes until postoperative 1 year
until 1 year after OPCAB

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cardioprotection and clinical adverse outcomes in diabetic patients
Time Frame: POD, POD 1, POD 2, one month, one year
primary and secondary outcome analysis in diabetic patients
POD, POD 1, POD 2, one month, one year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Samsung Medical Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2010

Primary Completion (Actual)

December 1, 2012

Study Completion (Actual)

December 1, 2012

Study Registration Dates

First Submitted

August 17, 2014

First Submitted That Met QC Criteria

August 20, 2014

First Posted (Estimate)

August 21, 2014

Study Record Updates

Last Update Posted (Estimate)

August 21, 2014

Last Update Submitted That Met QC Criteria

August 20, 2014

Last Verified

August 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2013-09-127

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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