- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02424279
Invasive Treatment of Pain Associated With Pancreatic Cancer on Different Levels of WHO Analgesic Ladder
Pancreatic cancer is a difficult to treat disease, mainly due to the fact that diagnosis is made usually in the late stage of this condition. One of the treatment methods of pain accompanying this neoplasm is thoracoscopic splanchnicectomy. It has been shown that it is a safe procedure with a small percentage of complications, nevertheless it is often use as the last stage in pain management what significantly decreases its effectiveness.
The aim of this study is to determinate the effect of invasive pain treatment (splanchnicectomy) in patients with advanced pancreatic cancer on subjective pain perception at rest, in movement and after meals (measured with the BPI, QLQ- C30 and FACIT questionnaires), and suffering (measured with PRISM projection test), the use of painkillers during the disease and patients' overall survival. Moreover the investigators want to check if early performance of splanchnicectomy (on lower steps of analgesic ladder WHO) is combined with better therapeutic effect of this treatment.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Gdansk, Poland
- Recruiting
- Department of General, Endocrine and Transplant Surgery, Medical University of Gdansk.
-
Contact:
- Łukasz Dobosz, M.D.
- Phone Number: +48604904644
- Email: lukaszdobosz@gumed.edu.pl
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients diagnosed with pancreatic cancer
- Age over 18 years
- Signed informed consent to participate in the study
Exclusion Criteria:
- Age under 18 years
- Intellectual inability to fill the questionnaires
- Co-occurrence of a disease in which significant chronic pain exists, which was recognized before the onset of pancreatic cancer
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Surgical treatment
Patients from the first group will undergo thoracoscopic splanchnicectomy.
The surgery will be performed in general anaesthesia, with tracheal intubation in prone position.
The greater splanchnic nerve will be identified at its origin in sympathetic trunk, dissected together with all collaterals all the way down to the diaphragm and excised.
Additional splanchnic nerves (smaller, minimus) will be incised or excised if connected to the greater splanchnic nerve.
Single sutures will be applied to the skin.
Then the procedure will be repeated on the contralateral side.
|
|
No Intervention: Conservative Treatment
Patients from the second group will be offered best available conservative pain treatment.
The list of medication on stage 1 will include: paracetamol, ibuprofen, diclofenac.
On stage 2: stage 1 + codeine and tramadol.
On stage 3: stage 2 + morphine, fentanyl, oxycodone, pethidine.
Oral and transcutaneous routes will be preferred to intravenous, intramuscular and subcutaneous.
A need for elevation to the next step of analgesic ladder will be considered when the pain will be stronger than 6 points in Numeric Rating Scale (NRS) and will be present for more than 5 days.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change from baseline pain intensity at 1 year (BPI questionnaires)
Time Frame: one year
|
one year
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Quality of life and pain intensity measurement (measured with the QLQ- C30, FACIT and BPI questionnaires)
Time Frame: From date of randomization until the date of death from any cause,assessed up to 100 months
|
From date of randomization until the date of death from any cause,assessed up to 100 months
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- MUG10
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Pain
-
University Hospital Schleswig-HolsteinZealand University Hospital; European Regional Development Fund; Design School...CompletedPain, Acute | Pain, Chronic | Pain Measurement | Pain, CancerGermany
-
Flowonix MedicalApproved for marketingBack Pain | Leg Pain | Trunk Pain | Intractable Pain | Arm Pain
-
Dr. Negrin University HospitalCompletedPostoperative Pain, Acute | Postoperative Pain, ChronicSpain
-
Dow University of Health SciencesRecruitingLow Back Pain | Chronic Low-back Pain | Low Back Pain, Mechanical | Mechanical Low Back Pain | Pain, Chronic | Pain, Back | Lower Back Pain Chronic | CLBP - Chronic Low Back PainPakistan
-
George Washington UniversityRecruitingCervical Fusion | Pain, Back | Pain, Neck | Myofacial PainUnited States
-
Atatürk Chest Diseases and Chest Surgery Training...RecruitingPostoperative Pain | Postoperative Pain, Acute | Postoperative Pain, Chronic | VATSTurkey
-
Janssen Research & Development, LLCCompletedPain, Radiating | Pain, Burning | Pain, Crushing | Pain, Migratory | Pain, SplittingUnited States, France, Spain, Poland, Portugal
-
susanne beckerSNSFCompletedLow Back Pain | Pain, Acute | Pain, ChronicSwitzerland
-
Atatürk Chest Diseases and Chest Surgery Training...RecruitingPostoperative Pain | Thoracotomy | Postoperative Pain, Acute | Postoperative Pain, ChronicTurkey
-
Universitat Jaume ICompletedPain, Acute | Pain, Chronic | OncologySpain
Clinical Trials on Splanchnicectomy
-
Mayo ClinicPolycystic Kidney Disease FoundationCompletedKidney, Polycystic, Autosomal DominantUnited States
-
University of LouisvilleNorton HealthcareWithdrawnUnresectable Pancreatic CancerUnited States