Acute Effects of Fats on Satiety and Energy Needs

August 1, 2022 updated by: USDA Grand Forks Human Nutrition Research Center
The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Study Type

Interventional

Enrollment (Actual)

23

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • North Dakota
      • Grand Forks, North Dakota, United States, 58203
        • USDA Grand Forks Human Nutrition Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 50 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • body mass index between 18.0-34.9 kg/m2
  • free of major diagnosed, untreated medical conditions
  • controlled hypertension
  • non-smoking or use of other tobacco products, including e-cigarettes
  • not taking steroid-based medications
  • not planning to or currently attempting to gain or lose weight
  • willing to comply with study demands
  • use of oral contraceptives
  • low intake of long chain omega 3 fatty acids

Exclusion Criteria:

  • diagnosed eating disorders
  • diabetes (blood sugar ≥ 126 mg/dl)
  • hypertension (systolic ≥ 160 mmHg or diastolic > 100 mmHg)
  • diagnosed cardiovascular, pulmonary, skeletal and metabolic disease
  • currently pregnant or planning to become pregnant, or lactating
  • taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Other
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Saturated Fat (SFA)
30 grams saturated fat in the form of heavy whipping cream will be provided to subject in a smoothie drink
Other: SFA
High saturated fatty acid/SFA oil source
Experimental: Monounsaturated Fat (MUFA)
30 grams monounsaturated fat in the form of high oleic canola oil will be provided to subject in a smoothie drink
Other: MUFA
High monounsaturated fatty acid/MUFA oil source
Experimental: Polyunsaturated Fat Linoleic (PUFA-LA)
30 grams polyunsaturated fat in the form of high linoleic sunflower oil will be provided to subject in a smoothie drink
Other: PUFA-LA
High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source
Experimental: Polyunsaturated Fat Alpha-Linolenic (ALA)
30 grams polyunsaturated fat in the form of flaxseed oil will be provided to subject in a smoothie drink
Other: ALA
High polyunsaturated fatty acid (alpha-linolenic)/ALA oil source
Experimental: Polyunsaturated Fat Long Chain Omega-3 (LCn3)
30 grams polyunsaturated fat in the form of fish oil (Coromega Omega3 Squeeze) will be provided to subject in a smoothie drink
Other: LCn3
High polyunsaturated fatty acid (omega-3)/LCn3 oil source

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Acute effect of fat intake on energy expenditure as determined by metabolic rate
Time Frame: Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours
Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

USDA Grand Forks Human Nutrition Research Center

Investigators

  • Principal Investigator: Matthew Picklo, PhD, USDA Grand Forks Human Nutrition Research Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 1, 2015

Primary Completion (Actual)

October 30, 2019

Study Completion (Actual)

October 30, 2019

Study Registration Dates

First Submitted

July 7, 2015

First Submitted That Met QC Criteria

July 10, 2015

First Posted (Estimate)

July 14, 2015

Study Record Updates

Last Update Posted (Actual)

August 4, 2022

Last Update Submitted That Met QC Criteria

August 1, 2022

Last Verified

August 1, 2022

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • GFHNRC508

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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