- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02578342
Brain Activity in Adults With ADHD During Neuropsychological Tasks
Brain Activity and Functional Connectivity in Adults With Attention-Deficit Hyperactivity Disorder (ADHD) During Tasks of Motor Inhibition and Cognitive Switching
Study Overview
Status
Intervention / Treatment
Detailed Description
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent psychiatric disorders in children and adolescents. It is characterized by inattentive, hyperactive, impulsive behaviour and neuropsychological deficits. In 40-60% of cases emerge in childhood and persists into adulthood.
The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.
Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
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Aargau
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Aarau, Aargau, Switzerland, 5001
- Kantonsspital Aarau
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Three groups:
- healthy volunteers
- ADHD subjects receiving medications
- medication-naive ADHD subjects
Description
Inclusion Criteria:
- Participant is between 20-55 years old
- Participant is not pregnant
Exclusion Criteria:
- Participant is not able to consent him/herself
- Suspected or proven pregnancy
- Nursing
- Neurological diseases that could interfere with a diagnosis of ADHD
- Psychiatric comorbidity under treatment
- Previous history of psychiatric medication
- Substance abuse
- Intelligence quotient<75
- Claustrophobia
- Electrical simulator nerve or bone
- Implanted medication infusion pump
- Cerebral aneurysm clips
- Unstable medical condition
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Healthy volunteers
healthy volunteer between age of 20 to 55 will undergo MRI examination.
|
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
|
ADHD subjects without medication
Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination.
|
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
|
ADHD subjects with medication
Subjects with ADHD (20-55 years), under medication will undergo MRI examination.
|
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in blood oxygenation level dependency (BOLD)
Time Frame: 2 hours
|
The study consist solely of one MRI examination performed within 2 hours.
|
2 hours
|
Collaborators and Investigators
Sponsor
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 1410.000.055
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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