- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02788279
A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370)
December 3, 2019 updated by: Hoffmann-La Roche
A Phase III, Open-Label, Multicenter, Three-Arm, Randomized Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy vs. Regorafenib in Patients With Previously Treated Unresectable Locally Advanced or Metastatic Colorectal Adenocarcinoma
This is a Phase III, multicenter, open-label, three-arm, randomized study in participants with unresectable locally advanced or metastatic colorectal cancer (CRC) who have received at least two prior regimens of cytotoxic chemotherapy for metastatic disease.
The study compares regorafenib, a standard of care therapy in this setting, to cobimetinib plus atezolizumab and atezolizumab monotherapy.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
363
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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New South Wales
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Port Macquarie, New South Wales, Australia, 2444
- Port Macquarie Base Hospital;North Coast Cancer Institute
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St Leonards, New South Wales, Australia, 2065
- Northern Cancer Institute
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Sydney, New South Wales, Australia, 2076
- Sydney Adventist Hospital; Clinical Trial Unit
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Victoria
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Clayton, Victoria, Australia, 3168
- Monash Medical Centre; Oncology
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Frankston, Victoria, Australia, 3199
- Peninsula and south eastern haematology and oncology group
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Heidelberg, Victoria, Australia, 3084
- Austin Health; Cancer Clinical Trial Centre
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Bonheiden, Belgium, 2820
- Imeldaziekenhuis
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Bruxelles, Belgium, 1200
- Cliniques Universitaires St-Luc
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Charleroi, Belgium, 6000
- GHdC Site Notre Dame
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Kortrijk, Belgium, 8500
- Az Groeninge
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Leuven, Belgium, 3000
- UZ Leuven Gasthuisberg
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Alberta
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Calgary, Alberta, Canada, T2N 4N2
- Tom Baker Cancer Centre-Calgary
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute; Clinical Trials
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British Columbia
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Vancouver, British Columbia, Canada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
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Ontario
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Ottawa, Ontario, Canada, K1H 8L6
- The Ottawa Hospital
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Toronto, Ontario, Canada, M4N 3M5
- Sunnybrook Health Sciences Centre
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Quebec
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Montreal, Quebec, Canada, H3G 1A4
- McGill University Health Center, Cedar Cancer Center
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Montreal, Quebec, Canada, J4B 5Z7
- Hopital du Sacre-Coeur
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Quebec City, Quebec, Canada, G1J 1Z4
- CHU de Quebec
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Hong Kong, Hong Kong
- Tuen Mun Hospital; Clinical Oncology
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Hong Kong, Hong Kong
- Queen Mary Hospital; Dept. of Clinical Oncology
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Shatin, Hong Kong
- Prince of Wales Hosp; Dept. Of Clinical Onc
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Campania
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Napoli, Campania, Italy, 80131
- Azienda Osp Uni Seconda Università Degli Studi Di Napoli; Unità Operativa Oncologia Medica
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Emilia-Romagna
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Modena, Emilia-Romagna, Italy, 41100
- A.O. Universitaria Policlinico Di Modena; Oncologia
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Liguria
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Genova, Liguria, Italy, 16132
- Istit. Naz. per la Ricerca sul Cancro - Az. Osped. S. Martino
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Lombardia
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Milano, Lombardia, Italy, 20162
- Asst Grande Ospedale Metropolitano Niguarda; Dipartimento Di Ematologia Ed Oncologia
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Milano, Lombardia, Italy, 20133
- Irccs Istituto Nazionale Dei Tumori (Int);S.C. Medicina Oncologica 1
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Puglia
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San Giovanni Rotondo, Puglia, Italy, 71013
- IRCCS Ospedale Casa Sollievo Della Sofferenza; Oncologia
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Toscana
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Pisa, Toscana, Italy, 56100
- A.O. Universitaria Pisana; Oncologia
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Gyeonggi-do, Korea, Republic of, 10408
- National Cancer Center
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Jeollanam-do, Korea, Republic of, 58128
- Chonnam National University Hwasun Hospital
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Seoul, Korea, Republic of, 03080
- Seoul National University Hospital
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Seoul, Korea, Republic of, 06351
- Samsung Medical Center
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Seoul, Korea, Republic of, 05505
- Asan Medical Center - Oncology
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Seoul, Korea, Republic of, 120-752
- Yonsei University Health System/Severance Hospital
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Bydgoszcz, Poland, 85-796
- Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy
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Gdańsk, Poland, 80-214
- Uniwersyteckie Centrum Kliniczne; Klinika Onkologii i Radioterapii
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Gdynia, Poland, 81-519
- Szpitale Pomorskie Sp. z o. o.
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Krakow, Poland, 31-531
- Szpital Uniwersytecki w Krakowie, Oddział Kliniczny Kliniki Onkologii
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Lodz, Poland, 93-513
- Woj.Wielospecjalistyczne Centrum Onkologii i Traumatologii; Oddz.Hematologii Pododz.Chemioterapii
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Arkhangelsk, Russian Federation, 163045
- Arkhangelsk Regional Clinical Oncology Dispensary
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Moscow, Russian Federation, 105229
- N.N.Burdenko Main Military Clinical Hospital; Oncology Dept
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Omsk, Russian Federation, 644013
- BHI of Omsk region Clinical Oncology Dispensary
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Barcelona, Spain, 08035
- Hospital Univ Vall d'Hebron; Servicio de Oncologia
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Madrid, Spain, 28034
- Hospital Ramon y Cajal; Servicio de Oncologia
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Madrid, Spain, 28040
- Hospital Clinico San Carlos; Servicio de Oncologia
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Madrid, Spain, 28041
- Hospital Universitario 12 de Octubre; Servicio de Oncologia
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Navarra, Spain, 31008
- Hospital de Navarra; Servicio de Oncologia
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Valencia, Spain, 46010
- Hospital Clínico Universitario de Valencia; Servicio de Oncología
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Birmingham, United Kingdom, B9 5SS
- Birmingham Heartlands Hospital; Dept of Oncology
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London, United Kingdom, SW3 6JJ
- Royal Marsden Hospital - Fulham; Oncology Department
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Manchester, United Kingdom, M20 4BX
- The Christie; GI Research Office
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Oxford, United Kingdom, OX3 7LE
- Churchill Hospital; Department of Oncology
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Romford, United Kingdom, RM7 0AG
- Queen's Hospital
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Sheffield, United Kingdom, S10 2SJ
- Weston Park Hospital; Cancer Clinical Trials Centre
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Sutton, United Kingdom, SM2 5PT
- Royal Marsden Hospital; Dept of Medical Oncology
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California
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Duarte, California, United States, 91010
- City of Hope Comprehensive Cancer Center
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Connecticut
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New Haven, Connecticut, United States, 06520
- Yale Cancer Center; Medical Oncology
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District of Columbia
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Washington, District of Columbia, United States, 20007
- Georgetown University
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Florida
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Fort Myers, Florida, United States, 33901
- Florida Cancer Specialists; SCRI
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Jacksonville, Florida, United States, 32256
- Cancer Specialists; North Florida ;Jacksonville (AC Skinner Pkwy)
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Saint Petersburg, Florida, United States, 33705
- Florida Cancer Specialists.
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Illinois
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Harvey, Illinois, United States, 60426
- Ingalls Cancer Research Center
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Minnesota
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Edina, Minnesota, United States, 55435
- Southdale Cancer Clinic U of M Medical Center, Fairview- Edina
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Missouri
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Saint Louis, Missouri, United States, 63110
- Washington University School of Medicine
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New York
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East Setauket, New York, United States, 11733
- North Shore Hem Onc Associates
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New York, New York, United States, 10065
- Memorial Sloan Kettering Cancer Center
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Oklahoma
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Oklahoma City, Oklahoma, United States, 73142
- INTEGRIS Cancer Inst of OK
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Pennsylvania
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Pittsburgh, Pennsylvania, United States, 15232
- University of Pittsburgh Cancer Institute; Division of Medical Oncology
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Tennessee
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Chattanooga, Tennessee, United States, 37404
- SCRI Tennessee Oncology Chattanooga
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Nashville, Tennessee, United States, 37203
- Sarah Cannon Research Inst.
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Texas
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Houston, Texas, United States, 77030
- MD Anderson Cancer Center
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Washington
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Spokane, Washington, United States, 99208
- Medical Oncology Associates
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Disease-specific inclusion criteria:
- Histologically confirmed adenocarcinoma originating from the colon or rectum (Stage 4 American Joint Committee on Cancer [AJCC] 7th edition)
- Experienced disease progression or was intolerant to at least two systemic chemotherapy regimens for metastatic colorectal cancer that must have included fluroropyrimidines, irinotecan, and oxaliplatin; adjuvant regimen can be considered as one chemotherapy regimen for metastatic disease if the participant had disease recurrence within 6 months of completion; disease progression must have occurred within 3 months of the last systemic therapy administration
General inclusion criteria:
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Anticipated life expectancy greater than or equal to (>=) 3 months
- Adequate hematologic and end organ function
- Women of childbearing potential must agree to appropriately use an effective form of contraception (failure rate of less than [<] 1 percent [%] per year) during the treatment period, within 5 months after the last dose of atezolizumab, and within 3 months after the last dose of cobimetinib and regorafenib
- Men must agree not to donate sperm or have intercourse with a female partner without using appropriate barrier contraception during the treatment period and for 3 months after the last dose of either cobimetinib or regorafenib
- Provide an archival or newly obtained tumor tissue sample
Exclusion Criteria:
- After the approximate 5% cap for microsatellite (MSI)-high participants is reached, only MSI-stable participants will be eligible
- Once the 50% cap for wild-type RAS has been reached, only extended RAS-mutant participants will be eligible
- Major surgery or radiotherapy within 21 days prior to Cycle 1 Day 1 or anticipation of needing such procedure while receiving study treatment
- Treatment with any anti-cancer agent within 14 days prior to Cycle 1 Day 1
- Uncontrolled tumor-related pain. Participants requiring narcotic pain medication must be on a stable regimen at study entry
- Uncontrolled pleural effusion, pericardial effusion or ascites requiring repeated drainage more than once every 28 days. Indwelling drainage catheters (e.g., PleurX®) are allowed
- Active or untreated central nervous system (CNS) metastases are excluded
- Prior therapy with any cancer immunotherapy, MEK inhibitor, or regorafenib
- Participants with active malignancy (other than CRC) or a prior malignancy within the past 3 years are excluded. Participants with completely resected cutaneous melanoma (early stage), basal cell carcinoma, cutaneous squamous cell carcinoma, cervical carcinoma in-situ, breast carcinoma in-situ, and localized prostate cancer are eligible
- Unstable angina, new onset angina within last 3 months, myocardial infarction within last 6 months and current congestive heart failure New York Heart Association Class II or higher
- Left ventricular ejection fraction (LVEF) below institutional lower limit of normal or below 50%, whichever is lower
- Poorly controlled hypertension, defined as a blood pressure consistently above 150/90 millimeters of Mercury (mmHg) despite optimal medical management
- Human immunodeficiency virus (HIV) infection
- Active tuberculosis infection
- Severe infections within 2 weeks prior to Cycle 1 Day 1
- Active or chronic viral hepatitis B or C infection
- History of or evidence of retinal pathology on ophthalmologic examination that is considered a risk factor for central serous retinopathy, retinal vein occlusion, or neovascular macular degeneration
- Participants will be excluded if they currently have any of the risk factors as defined in the study protocol for retinal vein occlusion
- History of autoimmune disease
- History of idiopathic pulmonary fibrosis, organizing pneumonia, bronchiolitis obliterans, drug-induced pneumonitis, or idiopathic pneumonitis
- History of organ transplantation including allogeneic bone marrow transplantation
- Inability to swallow medications
- Malabsorption condition that would alter the absorption of orally administered medications
- Pregnant, lactating, breastfeeding, or intending to become pregnant during the study
- Administration of a live, attenuated vaccine within 4 weeks before randomization or anticipation of a live attenuated vaccine will be required during the study
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Atezolizumab
Participants will receive atezolizumab monotherapy 1200 milligrams (mg) intravenous (IV) on Day 1 in a 21-day cycle until disease progression according to Response Evaluation Criteria in Solid Tumors (RECIST) Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
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Participants will receive atezolizumab IV at 840 mg on Day 1 and Day 15 in a 28-day cycle as a combination therapy or at 1200 mg on Day 1 in a 21-day cycle as a monotherapy until disease progression according to RECIST Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
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Experimental: Cobimetinib + Atezolizumab
Participants will receive cobimetinib 60 mg orally on Days 1 to 21 plus atezolizumab 840 mg IV on Day 1 and Day 15 in a 28-day cycle until disease progression according to RECIST Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
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Participants will receive atezolizumab IV at 840 mg on Day 1 and Day 15 in a 28-day cycle as a combination therapy or at 1200 mg on Day 1 in a 21-day cycle as a monotherapy until disease progression according to RECIST Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
Participants will receive cobimetinib 60 mg orally on Days 1 to 21 in a 28-day cycle as a combination therapy until disease progression according to RECIST Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
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Active Comparator: Regorafenib
Participants will receive regorafenib 160 mg orally on Days 1 to 21 in a 28-day cycle until disease progression according to RECIST Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
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Participants will receive regorafenib 160 mg orally on Days 1 to 21 in a 28-day cycle until disease progression according to RECIST Version 1.1, unacceptable toxicity, death, participant's or physician decision to withdraw, or pregnancy, whichever occurs first.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall Survival (OS)
Time Frame: From randomization up to death due to any cause (up to approximately 20 months)
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Overall survival is defined as the time (in months) between the date of randomization and the date of death due to any cause.
Participants who were not reported as having died at the date of analysis were censored at the date when they were last known to be alive.
Participants who did not have post-baseline information were censored at the date of randomization + 1 day.
Median OS was estimated by Kaplan-Meier method and 95% CI was assessed using the method of Brookmeyer and Crowley.
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From randomization up to death due to any cause (up to approximately 20 months)
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Progression-Free Survival (PFS) as Determined by the Investigator According to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1)
Time Frame: From randomization up to disease progression or death due to any cause (up to approximately 20 months)
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PFS was defined as the time from randomization to disease progression as determined by the investigator with the use of RECIST v1.1 or death due to any cause, whichever occurred earlier.
Disease progression was defined as at least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study, including baseline.
In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 millimeters (mm).
For non-target lesions, disease progression was defined as unequivocal progression of existing lesions.
The appearance of one or more new lesions was also considered progression.
Participants who did not have post-baseline information were censored at the date of randomization + 1 day.
Median OS was estimated by Kaplan-Meier method and 95% CI was assessed using the method of Brookmeyer and Crowley.
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From randomization up to disease progression or death due to any cause (up to approximately 20 months)
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Percentage of Participants With Investigator-Assessed Objective Response of Complete Response (CR) or Partial Response (PR) According to RECIST Version 1.1
Time Frame: From randomization up to death due to any cause (up to approximately 20 months)
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PR was defined as at least a 30% decrease in the sum of diameters of target lesions, taking as reference the baseline sum of diameters.
CR was defined as disappearance of all target and non-target lesions and normalization of tumor marker levels (as applicable to non-target lesions).
Objective response and its 95% CI were calculated using the Clopper-Pearson method.
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From randomization up to death due to any cause (up to approximately 20 months)
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Duration of Response (DOR) According to RECIST Version 1.1
Time Frame: From first occurrence of CR or PR up to disease progression or death due to any cause (up to approximately 20 months)
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DOR is defined as the period measured from the date of the first occurrence of a CR or PR (whichever status is recorded first) until the first date that progressive disease or death is documented.
Disease progression was determined on the basis of investigator assessment with use of RECIST v1.1.
Median DOR was estimated using the Kaplan-Meier method, and the 95% CI was calculated using the method of Brookmeyer and Crowley.
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From first occurrence of CR or PR up to disease progression or death due to any cause (up to approximately 20 months)
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Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life-C30 Questionnaire (EORTC QLQ-C30) Physical Functioning Sub-scale Score
Time Frame: Baseline, end of the study (up to approximately 2.5 years)
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The EORTC QLQ-C30 questionnaire consisted of 30 questions generating five functional scores (physical, role, cognitive, emotional, and social); a global health status/global quality of life scale score; three symptom scale scores (fatigue, pain, and nausea and vomiting); and six stand alone one-item scores that capture additional symptoms (dyspnea, appetite loss, sleep disturbance, constipation, and diarrhea) and perceived financial burden.
All the scales and single-item scores were linearly transformed so that each score ranged from 0 to 100.
A higher score on the global health and functioning subscales is indicative of better functioning.
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Baseline, end of the study (up to approximately 2.5 years)
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Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life-C30 Questionnaire (EORTC QLQ-C30) Global Quality of Life Sub-scale Score at the End of the Study
Time Frame: Baseline, end of the study (up to approximately 2.5 years)
|
The EORTC QLQ-C30 questionnaire consisted of 30 questions generating five functional scores (physical, role, cognitive, emotional, and social); a global health status/global quality of life scale score; three symptom scale scores (fatigue, pain, and nausea and vomiting); and six stand alone one-item scores that capture additional symptoms (dyspnea, appetite loss, sleep disturbance, constipation, and diarrhea) and perceived financial burden.
All the scales and single-item scores were linearly transformed so that each score ranged from 0 to 100.
A higher score on the global health and functioning subscales is indicative of better functioning.
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Baseline, end of the study (up to approximately 2.5 years)
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Percentage of Participants With Adverse Events (AEs)
Time Frame: Baseline, end of the study (up to approximately 2.5 years)
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Baseline, end of the study (up to approximately 2.5 years)
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Plasma Concentration of Cobimetinib
Time Frame: Predose (0 hours) and 3 to 6 hours after dose on Day 15 of Cycles 1 and 4 (1 cycle = 28 days) (up to approximately 2.5 years).
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Predose (0 hours) and 3 to 6 hours after dose on Day 15 of Cycles 1 and 4 (1 cycle = 28 days) (up to approximately 2.5 years).
|
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Serum Concentration of Atezolizumab
Time Frame: Pre-infusion (0 hours) on Day 1 of Cycle 1 up to approximately 2.5 years. Detailed time frame is explained in the outcome measure description field.
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Pre-infusion (0 hours) on Day 1 of Cycles 1 to 4; 30 minutes post-infusion on Day 1 of Cycles 1 and 4; pre-infusion (0 hours) on Day 1 of Cycle 8 and every 8 cycles thereafter; at treatment discontinuation; 120 days after treatment discontinuation (up to approximately 2.5 years) (1 cycle = 28 days)
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Pre-infusion (0 hours) on Day 1 of Cycle 1 up to approximately 2.5 years. Detailed time frame is explained in the outcome measure description field.
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Percentage of Participants With Anti-Therapeutic Antibodies (ATAs) to Atezolizumab
Time Frame: Pre-infusion (0 hours) on Day 1 of Cycles 1 to 4, 8, and every 8 cycles thereafter; at treatment discontinuation; 120 days after treatment discontinuation (up to approximately 2.5 years) (1 cycle = 28 days)
|
Pre-infusion (0 hours) on Day 1 of Cycles 1 to 4, 8, and every 8 cycles thereafter; at treatment discontinuation; 120 days after treatment discontinuation (up to approximately 2.5 years) (1 cycle = 28 days)
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Barteselli G, Goodman GR, Patel Y, Caro I, Xue C, McCallum S. Characterization of Serous Retinopathy Associated with Cobimetinib: Integrated Safety Analysis of Four Studies. Drug Saf. 2022 Dec;45(12):1491-1499. doi: 10.1007/s40264-022-01248-2. Epub 2022 Oct 30.
- Eng C, Kim TW, Bendell J, Argiles G, Tebbutt NC, Di Bartolomeo M, Falcone A, Fakih M, Kozloff M, Segal NH, Sobrero A, Yan Y, Chang I, Uyei A, Roberts L, Ciardiello F; IMblaze370 Investigators. Atezolizumab with or without cobimetinib versus regorafenib in previously treated metastatic colorectal cancer (IMblaze370): a multicentre, open-label, phase 3, randomised, controlled trial. Lancet Oncol. 2019 Jun;20(6):849-861. doi: 10.1016/S1470-2045(19)30027-0. Epub 2019 Apr 16. Erratum In: Lancet Oncol. 2019 Jun;20(6):e293.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 5, 2016
Primary Completion (Actual)
March 9, 2018
Study Completion (Actual)
December 26, 2018
Study Registration Dates
First Submitted
May 27, 2016
First Submitted That Met QC Criteria
June 1, 2016
First Posted (Estimate)
June 2, 2016
Study Record Updates
Last Update Posted (Actual)
December 11, 2019
Last Update Submitted That Met QC Criteria
December 3, 2019
Last Verified
November 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- GO30182
- 2016-000202-11 (EudraCT Number)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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Hoffmann-La RocheCompletedTriple-Negative Breast CancerFrance, Canada, Israel, Italy, Argentina, Brazil, China, Croatia, Germany, Greece, Slovakia, Turkey, Saudi Arabia, Japan, India, Spain, United States, Czechia, Romania, United Kingdom, Morocco, South Africa, Vietnam, Russian Federation
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Hoffmann-La RocheCompletedTriple Negative Breast CancerUnited States, Korea, Republic of, Belgium, Canada, Germany, United Kingdom, Argentina, Australia, Brazil, Finland, France, Greece, Hungary, Poland, Slovenia, Spain, Taiwan, Turkey, Japan, Singapore, Colombia, Bosnia and Herzegovina, Guatema... and more
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Hoffmann-La RocheCompletedBladder CancerUnited States, France, Belgium, Korea, Republic of, United Kingdom, Czechia, Austria, Canada, Denmark, Greece, Italy, Netherlands, Portugal, Slovenia, Spain, Sweden, Turkey, Poland, Hungary, Switzerland, Japan, Taiwan, Australia, Norway, Germa... and more
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Hoffmann-La RocheCompletedTumorsFrance, United States, Denmark, Ireland, Italy, Turkey, United Kingdom, Canada, Brazil, Spain, Poland, Netherlands, Germany, Russian Federation, Austria, Finland, Norway, Switzerland
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Genentech, Inc.CompletedNeoplasmsUnited States, Spain, Belgium, Korea, Republic of, Canada, Australia, France
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Genentech, Inc.CompletedNon-Small Cell Lung CancerUnited States
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Hoffmann-La RocheCompletedNon-Squamous Non-Small Cell Lung Cancer, Squamous Non-Small Cell Lung CancerSpain, Italy, Poland, Brazil, Turkey, Serbia, France, Korea, Republic of, Romania, Hungary, Russian Federation, United States, United Kingdom, Germany, Greece, Japan, Thailand, Ukraine, China
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Hoffmann-La RocheCompletedCarcinoma, Non-Small-Cell LungChina, Korea, Republic of, Singapore, Thailand, Malaysia