The Acute Effect of Two Berry Extracts on Cognition and Mood in Adults Aged 40 to 60

June 20, 2016 updated by: Anthony Watson, Northumbria University

The first study of my PhD showed that acute supplementation of berry extracts can modulate cognitive behaviour in healthy adults. There is a growing body of evidence supporting an improvement in memory and learning performance in animal models following the ingestion of flavonoid rich fruits (Shukitt-Hale et al 2008;Spencer 2008; Spencer et al., 2008). However, study 2, showed no effect on any aspects of memory in healthy young adults after supplementation of the berry extracts. It is hypothesised that the lack of behavioural effects on memory of the berry juice in study 2 was because of the cohort used. These healthy adult participants were already performing near to their peak (Salthouse et al., 2009), and unlike study one, participants were not mentally fatigued enough to reveal subtle cognitive benefits.

The aims of the study are to examine if acute supplementation of two berry extracts in an older population can augment memory, attention and executive function. Secondly, the time course of these behavioural effects will be measured by multiple cognitive assessments throughout the day after consumption of the extracts.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

36

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United Kingdom
      • Newcastle Upon-Tyne, United Kingdom, NE18ST
        • Brain, Performance and Nutrition Research Centre

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

40 years to 60 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy
  • Non-smokers
  • Aged between 40 and 60 years

Exclusion Criteria:

  • History of neurological, vascular or psychiatric illness.
  • BMI greater than 35 kg/m2
  • Current diagnosis of depression and/or anxiety.
  • History or current diagnosis of drug/alcohol abuse.
  • Anaemia.
  • Any heart disorder.
  • Hypertension
  • Any respiratory disorder.
  • Diabetes.
  • Food intolerances/sensitivities.
  • Phenylketonuria.
  • Use tobacco products or have ceased in the last 6 months.
  • Currently taking, or have taken in the last 2 weeks, any prescribed, illicit or herbal drugs and food supplements.
  • Any known active infections.
  • HIV antibody positive.
  • Currently have, have ever had, or may be at risk of hepatitis.
  • Have suffered from jaundice within the last year.
  • Have haemophilia or any similar clotting disorder.
  • History of head trauma
  • History of migraines
  • History of learning difficulties
  • Any Issues with giving blood samples.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Triple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Placebo Comparator: Control
Sugar matched control containing no phytochemicals
Dietary supplement: Control
Sugar matched control containing berry flavouring and no phytochemicals
Experimental: Juiced berry drink
Cold pressed berry drink standardised to contain 500mg of berry polyphenols
Dietary supplement: Berry drink
Cold pressed berry drink standardised to contain 500mg of berry polyphenols
Experimental: Powdered berry drink
Berry drink made up from a powdered concentrate. each drink will be standardised to contain 500mg of polyphenols
Dietary supplement: Powdered berry drink
Berry drink made from a powder concentrate standardised to contain 500mg of polyphenols

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Blood glucose
Time Frame: Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose
Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose
Blood lactate
Time Frame: Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose
Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose
Monoamine oxidase B inhibition
Time Frame: Change from baseline at 350 minutes post dose
Change from baseline at 350 minutes post dose
Cognitive Measures - Memory- Assessed using a computerised cognitive batter.
Time Frame: Change from baseline 60, 150, 240 and 360 minutes post dose
Change from baseline 60, 150, 240 and 360 minutes post dose
Cognitive Measures - Attention- Assessed using a computerised cognitive batter.
Time Frame: Change from baseline 60, 150, 240 and 360 minutes post dose
Change from baseline 60, 150, 240 and 360 minutes post dose

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Northumbria University

Collaborators

The New Zealand Institute for Plant and Food Research

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2012

Primary Completion (Actual)

May 1, 2013

Study Completion (Actual)

May 1, 2013

Study Registration Dates

First Submitted

November 8, 2012

First Submitted That Met QC Criteria

June 20, 2016

First Posted (Estimate)

June 23, 2016

Study Record Updates

Last Update Posted (Estimate)

June 23, 2016

Last Update Submitted That Met QC Criteria

June 20, 2016

Last Verified

June 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • 28AI5

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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