Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods. (Lungbaro)

Intraoperative Measurement of Lung Elastance and Transpulmonary Pressure Using Two Different Methods

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations i esophagus pressure divided by the tidal volume. This requires the presence of a esophageal balloon catheter which is cumbersome and costly. In this study values obtained as described above are compared to values obtained with a new method in which a stepwise increase in positive endexpiratory pressure (PEEP) is performed with a size which corresponds to the tidal volume which the patient is ventilated with. These measurements are performed in anesthetized patients prior to major surgery.

Study Overview

• Status: Completed
• Conditions: Anesthesia
• Intervention / Treatment: Other: Measurement of lung elastance by two methods

Detailed Description

Classically lung elastance and transpulmonary pressure are measured from the difference in tidal variations of airway pressure subtracted by tidal variations in esophageal pressure divided by the tidal volume (Method 1). This requires the presence of a esophageal balloon catheter which is cumbersome and costly.

In this study values obtained as described in Method 1 above are compared to values obtained with a new method in which a PEEP-step is performed with a size which corresponds to the tidal volume which the patient is ventilated with. Measurements using Method 1 and 2 are performed in anesthetized patients prior to major surgery.

• Study Type: Observational
• Enrollment (Actual): 24

Contacts and Locations

Study Locations

• Sweden
  • Gothenburg, Sweden, S-413 45
    • Sahlgrenska University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients which are anesthetized and muscle relaxed and are planned to undergo major surgery

Description

Inclusion Criteria:

• Patient undergoing major surgery during anesthesia and muscle relaxation

Exclusion Criteria:

• Patient with chronic obstructive lung disease

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Lung elastance - transpulmonary pressure; Lung elastance and transpulmonary pressure measured by tidal esophageal pressure variations and by performing a PEEP step	Other: Measurement of lung elastance by two methods; Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Measurement of lung elastance	Comparison of two method for measurements of lung elastance (Measurement of tidal variations in esophageal pressure followed in the same patient by performing a PEEP-step while simultaneously measuring the change in lung volume)	At 1 hour

Collaborators and Investigators

• Sponsor: Stefan Lundin
• Investigators: Principal Investigator: Stefan Lundin, Professor, Sahlgrenska University Hospital, Sweden

Publications and helpful links

General Publications

• Persson P, Stenqvist O, Lundin S. Evaluation of lung and chest wall mechanics during anaesthesia using the PEEP-step method. Br J Anaesth. 2018 Apr;120(4):860-867. doi: 10.1016/j.bja.2017.11.076. Epub 2017 Dec 1.

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2016
• Primary Completion (Actual): December 31, 2016
• Study Completion (Actual): December 31, 2016

Study Registration Dates

• First Submitted: June 21, 2016
• First Submitted That Met QC Criteria: July 12, 2016
• First Posted (Estimate): July 13, 2016

Study Record Updates

• Last Update Posted (Actual): January 8, 2018
• Last Update Submitted That Met QC Criteria: January 5, 2018
• Last Verified: January 1, 2018

More Information

Terms related to this study

• Other Study ID Numbers: LUA-74201

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED