- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02846207
Yiqi Huoxue Demolition and Recipes on Recovery Stage of Cerebral Infarction
February 8, 2018 updated by: Dongfang Hospital Beijing University of Chinese Medicine
Study of Effects and Mechanisms of Yiqi Huoxue Demolition and Recipes on Recovery Stage of Cerebral Infarction
This clinical research is based on the fundamentals of using Chinese medicine, which will improve Qi and promote blood circulation, to treat patients in the recuperating stages of cerebral infarction with deficiency in Qi and blood stasis syndrome.
By assimilating Chinese medical theory, this research aims to study the biological basics of the stroke and the cause for the deficiency in Qi and blood stasis syndrome; explore the therapeutic mechanism of the treatment methods; as well as ascertaining the relationship between Qi, blood and blood vessels.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
Cerebral infarction, or ischemic stroke, is a common yet challenged illness with four telltale signs (high occurrence rate, high incapacitate rate, high mortality rate, and high recurrence rate), posing not only a threat to a man's health and life, but also imposing a burden to the society and his loved ones.
As such, seeking a cure has always been the hot topic in this field of research.
With regard to the illness' high incapacitate and recurrence rates, it has become apparent that the treatment methods used in the recuperating stages of stroke are very significant to the patient, allowing him the chance to regain his health and increase his quality of life.
In Chinese medical terms, the pathogenesis key of stroke is a deficiency in the vitals of the body coupled with superficiality extremities.
As such, in the recuperating stage of the stroke, a lack of Qi accompanied with blood stasis syndrome is often observed.
Hence, improving Qi and promoting blood circulation is essential during treatment.
Research further supports that this treatment method is highly effective in treating cerebral infarction, but the mechanism involved is still incomprehensible, largely due to the fact that the pathology of cerebral infraction is highly complicated, and that Chinese medicine is multi-leveled, multi-channeled, with multi-targets.
To further study the relationship of Qi and blood in cerebral infraction, patients in the recuperating stages with deficiency in Qi and blood stasis underwent observation in a double blind clinical research.
The patients were sorted in random into groups: improving Qi group, promoting blood circulation group, improving Qi and promoting blood circulation group, and the control group.
Each group of patients was given the standard Western medicine treatment, coupled with Chinese medicine treatments with respect to their sorted groupings.
The treatment lasts for 12 weeks and 360 clinical cases were studied.
Testing methods used include enzyme linked immunosorbent assay, Western Blot, FQ RT-PCR, LC-MS, and radiology.
Through the relations between Neurotransmitter - endocrine hormone - immune cytokine network, blood rheology, vascular structure and endothelial function, interactions involving vasoactive substances with vascular endothelium and blood cells, it is hoped that the biological basis of cerebral infraction's deficiency in Qi and blood stasis syndrome can be deciphered.
This will aid in the understanding of the whole process of causing the syndrome, deciphering the therapeutic mechanism involved during treatment, as well as determining the relationship between Qi, blood and blood vessels.
Study Type
Interventional
Enrollment (Anticipated)
360
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Guo Ronguan, PhD,MD
- Phone Number: +86 10 67689634
- Email: Dfguorongjuan@163.com
Study Contact Backup
- Name: Guo Rongjuan, PhD,MD
- Phone Number: +86 10 67689634
- Email: Dfguorongjuan@163.com
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 100078
- Recruiting
- Dongfang Hospital
-
Contact:
- Guo Rongjuan, PhD,MD
- Phone Number: +86 10 67689634
- Email: Dfrongjuanguo@163.com
-
-
Hebei
-
Xingtai, Hebei, China, 054001
- Recruiting
- Xingtai People's Hospital
-
Contact:
- Wang Jianhua, PhD,MD
-
-
Henan
-
Zhengzhou, Henan, China, 450000
- Recruiting
- The First Affiliated Hospital of Henan Univerisity of TCM
-
Contact:
- Liu Xiangzhe, PhD,MD
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
35 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- In accordance to the Western medicine diagnostic criteria for atherosclerotic thrombotic cerebral infarction;
- In accordance to the Chinese medicine diagnostic criteria for stroke, with deficiency in Qi and blood stasis syndrome;
- In accordance to Stroke's diagnostic scale factor standards: asthenic Qi syndrome ≥ 10 points, blood stasis ≥ 10 points;
- Within the recuperating stage of the illness (2 weeks to 6 months);
- National Institutes of Health Stroke Scale (NIHSS) with a score of 3-22 points;
- Ages within 35-80;
- Signature of consent to participate in the research.
Exclusion Criteria:
- Patients suffering from transient ischemic attack (TIA), subarachnoid haemorrhage and cerebral haemorrhage;
- Patients suffering from cerebral embolism due to superficiality extremities caused by rheumatic heart disease, coronary heart disease and other heart diseases coupled with atrial fibrillation; stroke patients caused by brain tumor, head trauma, blood diseases, etc;
- Pregnant women or women planning for pregnancy, women with positive urine pregnancy test, and lactating women;
- Patients with severe hepatic and renal dysfunction, severe disease of the hematopoietic system, highly active ulcer and bleeding tendency, severe disease of the endocrine system, severe bone and joint disease, and arrhythmia patients with great clinical significance;
- Patients with mental impairment, or mental disability, or severely deaf, or unconscious, or being uncooperative during inspection;
- Patients with known allergies to the medicine used, as well as overly sensitive patients;
- Patients that underwent clinical trials within the past 3 months.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Yiqi huoxue group
Buyang Huanwu decoction , which includes: Astragalus 60g, Radix Paeoniae Rubra 15g, ligusticum wallichii 12g, angelica sinensis 20g, earthworm 12g, flos carthami 12g and peach seed 12g.
Oral administration, twice one day, for 12weeks.
|
Buyang Huanwu demolition, which includes: Astragalus 60g, Radix Paeoniae Rubra 15g, ligusticum wallichii 12g, angelica sinensis 20g, earthworm 12g, flos carthami 12g and peach seed 12g.
Oral administration, twice one day, for 12weeks.
Other Names:
|
Experimental: Yiqi group
Astragalus 60g.
Oral administration, twice one day, for 12weeks.
|
Astragalus 60g.Oral administration, twice one day, for 12weeks.
Other Names:
|
Experimental: Huoxue group
Radix Paeoniae Rubra 15g, ligusticum wallichii 12g, angelica sinensis 20g, earthworm 12g, flos carthami 12g and peach seed 12g.
Oral administration, twice one day, for 12weeks.
|
Radix Paeoniae Rubra 15g, ligusticum wallichii 12g, angelica sinensis 20g, earthworm 12g, flos carthami 12g and peach seed 12g.
Oral administration, twice one day, for 12weeks.
Other Names:
|
Placebo Comparator: placebo group
dextrin, Oral administration, twice one day, for 12weeks.
|
Dextrin,oral administration, twice one day, for 12weeks.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
National Institute of Health Stroke Scale
Time Frame: 12 weeks
|
NIHSS
|
12 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Modified Rankin scale
Time Frame: 12 weeks
|
0-5scales
|
12 weeks
|
Barthel index
Time Frame: 12 weeks
|
0-100scales
|
12 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Liu Xiangzhe, PHD,MD, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
- Principal Investigator: Wang Jianhua, PHD,MD, Xingtai People's Hospital
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
March 1, 2016
Primary Completion (Anticipated)
December 1, 2019
Study Completion (Anticipated)
December 1, 2019
Study Registration Dates
First Submitted
March 20, 2016
First Submitted That Met QC Criteria
July 24, 2016
First Posted (Estimate)
July 27, 2016
Study Record Updates
Last Update Posted (Actual)
February 12, 2018
Last Update Submitted That Met QC Criteria
February 8, 2018
Last Verified
February 1, 2018
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2015CB554401
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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