- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03072511
Smoking Cessation Intervention (SPOTLIGHT)
January 21, 2020 updated by: University of Florida
Pilot Trial of a Smoking Cessation Intervention Informed by Construal Level Theory
Cigarette smoking is the leading cause of preventable mortality in the United States, yet less than 10% of smokers making a serious quit attempt remain abstinent from cigarettes 1 year later, and outcomes from gold-standard behavioral interventions leave much room for improvement.
As such, in the context of a Stage-I randomized controlled trial (RCT), this study will examine (1) treatment characteristics and delivery, treatment integrity, dropout, and acceptability, (2) smoking outcomes such as lapse, relapse, and abstinence measures, and (3) changes decision-making that result from a novel intervention informed by behavioral analysis and social cognition.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
Cigarette smoking is the leading cause of preventable mortality in the United States, implicated in countless health consequences, and significant economic and societal costs.
Less than 10% of smokers making a serious quit attempt remain abstinent from cigarettes 1 year later, and outcomes from gold-standard behavioral interventions leave much room for improvement.
Thus the development of new interventions and improvements to existing interventions is imperative.
Behavioral interventions for smoking cessation have insufficiently integrated the findings from basic research on decision-making processes.
Thus, there is extensive laboratory-based research indicating the potential for laboratory-based manipulations that affect decision making relevant for smoking, the examination of a coherent intervention that capitalizes on this knowledge is limited.
The proposed research is the first step toward synthesizing insights from the research domains of addiction, behavioral analysis, and social cognition into a cohesive formulation with potential impact on smoking cessation.
Specifically, the research targets impulsive decision making associated with cigarette smoking and relapse by incorporating the influential Construal Level Theory.
Study Type
Interventional
Enrollment (Actual)
23
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Florida
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Gainesville, Florida, United States, 32611
- University of Florida
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Current cigarette smoker (verified with an expired carbon monoxide level of at least 4 ppm of expired air),
- At least 18 years of age,
- With a desire to quit smoking in the next month (at least 5 on a 10-point scale).
Exclusion Criteria:
- Pregnancy,
- Having uncontrolled serious psychiatric or medical illnesses,
- Having recent suicide attempts or ideation,
- Meeting contraindications for use of nicotine replacement products,
- Taking pharmocotherapy for smoking cessation treatment.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Spotlight on Smoke-Free Living
Treatment will include a 1.5-hour intervention session combined with daily text-messaging for up to 1 week pre-quit and 4 weeks post-quit.
The intervention includes: mindful breathing, visualization, and identification and thinking about goals and priorities inconsistent with smoking.
During the text-messaging phase, elements of the intervention discussed during the in-person session will be reinforced.
Participants will be provided transdermal nicotine patches (TNP).
TNP are a safe and effective approach to nicotine replacement when an individual attempts to stop smoking and are safe for use without prescription.
Participants will begin the regimen on the scheduled quit date with an initial dose of 21 mg (4 weeks), followed by 14 mg (2 weeks), and 7 mg (2 weeks).
Alterations to dosing will be allowed when appropriate and consistent with manufacturer's recommendations.
While TNP will be offered to all participants, they can decline or discontinue use of TNP at any time.
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Intervention will consist of elements to help quit smoking.
All intervention elements will be informed by Construal Level Theory.
Other Names:
TNP serve as nicotine replacement for individuals who are attempting to stop smoking.
They are safe for use and dosing will be determined for each participant based off of manufacturer's recommendations.
Other Names:
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Active Comparator: Standard Informational Treatment
Standard informational treatment is based on conventional, information-based smoking cessation approaches commonly found in public health settings.
This will include the following information: prevalence/incidence of cigarette smoking and negative health outcomes associated with cigarette smoking (e.g., cancer, respiratory disease, complications), other health consequences resulting from diseases associated with cigarette smoking, personal/financial/social consequences of cigarette smoking.
During the text-messaging phase, information about the consequences of smoking discussed during the in-person session will be reiterated.
As with the experimental condition, participants will be provided with 8-weeks TNP.
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TNP serve as nicotine replacement for individuals who are attempting to stop smoking.
They are safe for use and dosing will be determined for each participant based off of manufacturer's recommendations.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
7-day smoking point prevalence
Time Frame: 13 weeks
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Timeline Follow-Back: assesses smoking patterns through daily logs of smoking tendencies, use of nicotine patches, and attempts to quit.
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13 weeks
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Delay Discounting
Time Frame: 13 weeks
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Delay Discounting Task: a binary choice procedure where two hypothetical money rewards will be presented at specified delays.
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13 weeks
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Principal Investigator: Richard Yi, Ph.D., University of Florida
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 13, 2016
Primary Completion (Actual)
August 1, 2018
Study Completion (Actual)
August 1, 2018
Study Registration Dates
First Submitted
March 1, 2017
First Submitted That Met QC Criteria
March 1, 2017
First Posted (Actual)
March 7, 2017
Study Record Updates
Last Update Posted (Actual)
January 23, 2020
Last Update Submitted That Met QC Criteria
January 21, 2020
Last Verified
January 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB201601307 - N
- K02DA034767 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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