Development of a Musculoskeletal Model of the PIP Joint

Development of Parametric Musculoskeletal Models to Investigate the Anatomy and the Function of the PIP

The proximal interphalangeal (PIP) joint is the second joint in the finger from the finger tip. The outcome following replacement surgery of this joint is considered unsatisfactory. In order to improve these outcomes, it would be helpful to understand the geometry of the joint, how it moves and the forces that are involved. This can be achieved using computer models that model the bones and the soft tissues - musculoskeletal models. In order to make these models as representative as possible, they should be generated using anatomical data.

Data will initially be extracted from patients' existing magnetic resonance imaging (MRI) and computed tomography (CT) scans. This will enable the computer model to begin being constructed. In parallel to the model initialisation, anatomical and motion data of the PIP joint of healthy volunteers will be collected. The necessary data will be collected using CT and MRI scans, as well as optical motion tracking methods. These data will then be used to populate the musculoskeletal model.

Once the model is constructed, it will be used to simulate the motion of the joint and look at the effect of a simulated PIP joint replacement. This information should then provide insight as to how PIP joint replacements might be improved in future.

Study Overview

• Status: Completed
• Conditions: Patient Specific Computational Modeling
• Intervention / Treatment: Other: Motion capture; Diagnostic test: MR scan; Diagnostic test: CT scan

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Hampshire
    • Southampton, Hampshire, United Kingdom, SO17 1BJ
      • University Hospital Southampton

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• In general good health
• University of Southampton members of staff
• Over 18 years old and able to provide informed consent
• No known problems relating to the PIP joint

Exclusion Criteria:

• Volunteers involved in other studies concerned with the function and anatomy of the PIP joint which would have adverse effects on this study and/or the study in which they are currently involved.
• Those undergoing treatment related to the PIP joint
• No metallic object should be present in the scanner and therefore those with any implanted metallic devices, or other devices which may cause or be caused adverse effects (e.g. metal plate, pacemaker)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: Motion capture, MR scan, CT scan; All volunteers will go through the same data collection process	Other: Motion capture; Capture kinematics of finger movements; Diagnostic test: MR scan; Capture MR images of hand and fingers in three postures; Diagnostic test: CT scan; Capture CT images of hand and fingers in three postures

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Capturing hand kinematics using Vicon optical motion capture	Capture hand kinematics of 10 healthy volunteers	3 years
Capturing images of the soft tissue in the hand using MR imaging	Capture MR images of the hand for same 10 healthy volunteers as Outcome 1	3 years
Capturing images of the bony structures in the hand using CT scanning	Capture CT images of the hand for same 10 healthy volunteers as Outcome 1	3 years

Collaborators and Investigators

• Sponsor: University of Southampton
• Investigators: Principal Investigator: Christopher WG Phillips, PhD, University of Southampton

Publications and helpful links

General Publications

• Adams J, Ryall C, Pandyan A, Metcalf C, Stokes M, Bradley S, Warwick DJ. Proximal interphalangeal joint replacement in patients with arthritis of the hand: a meta-analysis. J Bone Joint Surg Br. 2012 Oct;94(10):1305-12. doi: 10.1302/0301-620X.94B10.29035.

Study record dates

Study Major Dates

• Study Start (Actual): January 21, 2015
• Primary Completion (Actual): September 5, 2017
• Study Completion (Actual): September 5, 2017

Study Registration Dates

• First Submitted: March 9, 2017
• First Submitted That Met QC Criteria: March 22, 2017
• First Posted (Actual): March 29, 2017

Study Record Updates

• Last Update Posted (Actual): November 15, 2018
• Last Update Submitted That Met QC Criteria: November 14, 2018
• Last Verified: November 1, 2018

More Information

Terms related to this study

• Keywords: Kinematics; MRI Scans; CT Scan, Single-Photon Emission; finger interphalangeal joint
• Other Study ID Numbers: PUNI1713

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No