Zinc and Iron in Children With Short Stature (zincandiron)

Short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard zinc and iron have important role in growth for children

Study Overview

• Status: Completed
• Conditions: Zinc; Deficiency With Anemia
• Intervention / Treatment: Diagnostic test: serum zinc and iron

Detailed Description

Short stature is defined as height below 3rd centile or less than two standard deviations below the median height for that age and sex according to the population standard.

Approximately 3% children in any population will be short, amongst which half will be physiological (familial or constitutional) and half will be pathological.

It is estimated that approximately 60%-80% of all short children at or below 2standerd deviation fit the definition of idiopathic short stature.

The growth and development of human require an adequate supply of many different nutritional factors. Nutritional deficiencies causing short stature include: those associated with stunting as: protein and zinc, nutrient associated with rickts as :vitamin D, and those with bone abnormalities as: cupper,zin,and vitamin c Insufficient nutrition tends to lead to short stature with a delayed pattern of growth. Under-nutrition can be isolated (eg, caused by inadequate food supply or self-imposed restriction, such as fear of obesity), or it may be a component of an underlying systemic disease that interferes with food intake or absorption, or increases energy needs. The hallmark of under-nutrition is low weight-for-height .

Trace elements are dietary mineral that are present in very minute quantities (less than 0.01%),they divided into three groups (WHO classification): Essential elements such as iodine and zinc ,Probably essential elements such as manganese and silicon , Potentially toxic elements such as fluoride,lead,cadmium, mercury, & Lithium.

Trace elements play significant functions as growth,oregulation of gene expression, immunity,the endocrine system, brain development, and the cell protection system. An adequate micronutrient intake is crucial for health, particularly in infants, children and adolescents ,deficiency in micronutrients can affect growth and development, particularly during periods of rapid growth.

• Study Type: Observational
• Enrollment (Actual): 50

Contacts and Locations

Study Locations

• Egypt
  • Asiut, Egypt
    • Engy dawood

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 2 years to 18 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

50 cases will be included :35 child with idiopathic short stature and 25 as controls aging from4-18 years old coming to endocrinology clinic at Assuit University Children Hospital will be investigated for serum of zinc and iron

Description

Inclusion Criteria:

• • children of both sexes.

  • Age range: 4-18 years.
  • patients fulfilling criteria of short stature.
• height is 2 standard deviations below normal .
• initial height below the third percentile on Egyptian growth chart. • Number of patients: will include 50 cases

Exclusion Criteria:

• Skeletal dysplasia.
• Chromosomal anomalies

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
column heading in tables; history examinations investigation:serum zinc and iron	Diagnostic test: serum zinc and iron; history ,examination,investigations
row heading in tables; history examinations investigation:serum zinc and iron	Diagnostic test: serum zinc and iron; history ,examination,investigations

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
zinc and iron in children with idiopathic short stature	Assessment of the serum level of zinc and iron in idiopathic with short stature.	6 months

Collaborators and Investigators

• Sponsor: Assiut University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2017
• Primary Completion (Actual): January 1, 2018
• Study Completion (Actual): August 15, 2019

Study Registration Dates

• First Submitted: April 23, 2017
• First Submitted That Met QC Criteria: April 24, 2017
• First Posted (Actual): April 27, 2017

Study Record Updates

• Last Update Posted (Actual): October 30, 2020
• Last Update Submitted That Met QC Criteria: October 28, 2020
• Last Verified: October 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Endocrine System Diseases; Genetic Diseases, Inborn; Musculoskeletal Diseases; Bone Diseases; Bone Diseases, Developmental; Dwarfism
• Other Study ID Numbers: assiut university17100104

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided
• IPD Plan Description: patients aging 2-18years old will be dbtained at the start of the study

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No