- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03206814
Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System (CHARGE-APP)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
CHARGE-APP is a proof-of-concept one-year prospective, randomized, open-label, blinded endpoint study (PROBE) including 2 groups of patients randomized to different treatment strategies:
- a new management strategy, named POST (i.e. "Patient Optimal Strategy for Treatment"), consisting in providing the patients with a system to communicate home blood pressure measurements to a referral centre, and the referral centre with an online platform to organize and easily interpret the information sent by patients and to monitor the patients' status;
- usual care, consisting in regular visits at the referral centre.
Patients will be enrolled over 3 months and will be randomly allocated to one of the study groups. Follow-up phase will last 12 months after randomization and will focus on changes in ambulatory systolic BP (primary endpoint), in diastolic ambulatory BP, in office SBP and DBP, in Home SBP and DBP, in left ventricular mass index (LVMI) and urinary albumin excretion (UAE), all secondary end-points.
All patients will perform visits at baseline, three, six and twelve months. Physical examination, history of the patient and clinical blood pressure values will be obtained at every visit.
Echocardiogram, ECG, urine samples (UAE, urinary albumin/creatinine and 24-h ambulatory blood pressure monitoring (ABPM) will be performed at baseline, three months, six months and study end.
Blood samples (full blood count, creatinine, Na+, K+, fasting glucose, HbA1c, uric acid, lipids) will be performed at baseline; another blood sample will be collected at twelve months for measurement of serum creatinine (and renal function). UAE will be measured at baseline and study end, on morning urine samples.
Patients randomized to POST-strategy will measure Home BP two days a week (two measurements in the morning and two measurements in the evening) and communicate these values with the ESH CARE app; furthermore, before each visit they will measure their Home BP for 7 consecutive days (two measurements in the morning and two measurements in the evening), according to current guidelines on hypertension.
Patients randomized to usual care will also measure Home BP for 7 consecutive days at baseline and at study end, to provide a comparison. Operators (i.e. investigators dedicated to the follow-up of POST-strategy) will check these data organized by the POST system at least every 15 days, and adjust pharmacological therapy, if needed.
In patients randomized to usual care, therapy will be adjusted only at follow-up visits (i.e. at three and six months).
Pharmacological therapy will be increased or decreased according to blood pressure values; investigators may follow a therapy algorithm based on ESH/ESC guidelines, but are free to individualize it.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Gianfranco Parati, MD
- Phone Number: 2890 +390261911
- Email: gianfranco.parati@unimib.it
Study Contact Backup
- Name: Paulina Wijnmaalen, MD
- Phone Number: 2968 +390261911
- Email: charge-app@auxologico.it
Study Locations
-
-
-
Mendoza, Argentina, M5501
- Not yet recruiting
- Spanish Hospital of Mendoza
-
Contact:
- Nicolas Renna, MD
- Email: nicolasfede@gmail.com
-
-
-
-
Huangpu
-
Shanghai, Huangpu, China
- Recruiting
- Shanghai Institute of Hypertension
-
Contact:
- Jiguang Wang, Prof
- Email: jiguangw@163.com
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Male and female subjects;
- Age 18-80 years;
- Either the patient or another person close to him/her should possess a smartphone compatible with the ESH CARE app and be capable of using it;
- Uncontrolled (untreated or treated) hypertension, defined as office BP ≥140/90 mmHg, and Ambulatory 24h ABP ≥130/80 mmHg
Exclusion Criteria:
- eGFR <45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009);
- Severe uncontrolled hypertension (i.e. BP ≥200/120 mmHg despite treatment);
- Known secondary hypertension;
- Orthostatic hypotension (SBP fall > 20 mmHg on standing);
- Unstable clinical conditions or severe disease with short life expectation;
- Known atrial fibrillation;
- Hepatic disease as determined by either AST or ALT values > 2 times the upper limit of normal;
- History of gastrointestinal surgery or disorders which could interfere with drug absorption
- History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years;
- History of clinically significant autoimmune disorders such as systemic lupus erythematosus;
- History of drug or alcohol abuse within the last 5 years;
- History of non-compliance to medical regimens and/or patients who are considered potentially unreliable;
- Dementia (clinical diagnosis);
- Inability or unwillingness to give free informed consent;
- Inability to use even simple communication technologies;
- Pregnancy or planned pregnancy during study period
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Group 1 - Usual care
Standard strategy for management of hypertension, based on three-monthly visits at the referral centre.
|
Antihypertensive therapy is adjusted every 3 months on the basis of office blood pressure values.
|
Experimental: Group 2 - POST-strategy
Patient Optimal Strategy for Treatment (POST) for management of hypertension, based on on three-monthly visits at the referral centre + providing the patients with the ESH-CARE APP system to communicate home blood pressure measurements to the referral centre, and the referral centre with an online platform to monitor the patients' status.
|
Antihypertensive therapy is adjusted every 15 days on the basis of home blood pressure values.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Ambulatory Systolic Blood Pressure
Time Frame: 12 months
|
Change in ambulatory 24h systolic blood pressure
|
12 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Ambulatory Diastolic Blood Pressure
Time Frame: 12 months
|
Change in ambulatory 24h diastolic blood pressure
|
12 months
|
Difference between Office Blood Pressure and Home Blood Pressure
Time Frame: 12 months
|
Differences between office blood pressure and home blood pressure (both systolic and diastolic)
|
12 months
|
Left ventricular mass index
Time Frame: 12 months
|
Change in left ventricular mass index by ecocradiographic evaluation
|
12 months
|
Left ventricular hypertrophy
Time Frame: 12 months
|
Change in ECG indices of left ventricular hypertrophy
|
12 months
|
Urinary albumin to creatinine ratio
Time Frame: 12 months
|
Change in urinary albumin to creatinine ratio
|
12 months
|
Estimated glomerular filtration rate
Time Frame: 12 months
|
Change in estimated glomerular filtration rate
|
12 months
|
Normalization rate of blood pressure
Time Frame: 12 months
|
Normalization rate of BP by all the measuring devices: office BP, HOME BP and ABPM
|
12 months
|
ABPM variables
Time Frame: 12 months
|
Change in a number of variables derived from ABPM (day-time SBP/DBP, Night-time SBP/DBP, nocturnal dipping of SBP/DBP, morning surge of SBP/DBP, BPV (daytime and night-time SBP/SBP SD, CV; 24h SBP/DBP ARV, 24h SBP/DBP wSD, AASI)
|
12 months
|
Prescribed antihypertensive drugs
Time Frame: 12 months
|
Number of prescribed antihypertensive drugs
|
12 months
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Gianfranco Parati, MD, Istituto Auxologico Italiano
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 09A721
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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