Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea

A Multicenter, Randomized, Double-Blind, Parallel Group, Vehicle-Controlled Study to Evaluate the Safety and Efficacy of 1% and 3% Topical MIinocycline Gel (HY01) in Patients With Papulopustular Rosacea

To evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, as assessed by the change in inflammatory lesion count from baseline over the 12-week treatment period in patients with moderate-to-severe papulopustular rosacea.

Study Overview

• Status: Completed
• Conditions: Rosacea; Papulopustular Rosacea
• Intervention / Treatment: Other: Topical Vehicle Gel; Drug: 1% Topical Minocycline Gel; Drug: 3% Topical Minocycline Gel

• Study Type: Interventional
• Enrollment (Actual): 270
• Phase: Phase 2

Contacts and Locations

Study Locations

• United States
  • Arkansas
    • Bryant, Arkansas, United States, 72022
      • Clinical site - 15
    • Rogers, Arkansas, United States, 72758
      • Clinical site - 20
  • California
    • Fremont, California, United States, 94538
      • Center for Dermatology Clinical Research, Inc.
    • Santa Monica, California, United States, 90404
      • Clinical site - 19
  • Florida
    • Tampa, Florida, United States, 33624
      • Clinical site - 5
  • Idaho
    • Boise, Idaho, United States, 83704
      • Clinical site - 16
  • Massachusetts
    • Boston, Massachusetts, United States, 02116
      • Clinical Site - 22
    • Watertown, Massachusetts, United States, 02472
      • Clinical Site - 23
  • Michigan
    • Clinton Township, Michigan, United States, 48038
      • Clinical site - 14
  • Minnesota
    • Fridley, Minnesota, United States, 55432
      • Clinical site - 6
  • Nebraska
    • Omaha, Nebraska, United States, 68144
      • Clinical site - 12
  • New Jersey
    • Berlin, New Jersey, United States, 08009
      • Clinical Site - 21
  • New York
    • New York, New York, United States, 10022
      • Clinical site - 13
    • New York, New York, United States, 10155
      • Clinical site - 2
  • North Carolina
    • High Point, North Carolina, United States, 27262
      • Clinical site - 4
  • Oregon
    • Portland, Oregon, United States, 97210
      • Clinical site - 17
  • Pennsylvania
    • Fort Washington, Pennsylvania, United States, 19034
      • Clinical site - 11
  • Tennessee
    • Goodlettsville, Tennessee, United States, 37072
      • Clinical site - 8
  • Texas
    • Pflugerville, Texas, United States, 78660
      • Clinical site - 7
    • San Antonio, Texas, United States, 78213
      • Clinical Site - 18
    • San Antonio, Texas, United States, 78229
      • Clinical site - 3
    • San Antonio, Texas, United States, 78229
      • Clinical site - 9
  • Virginia
    • Norfolk, Virginia, United States, 23502
      • Clinical Site - 10

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Subjects who had provided written informed consent to participate in the study.
• Male or non-pregnant female aged ≥ 18 years with a clinical diagnosis of moderate to severe facial rosacea, defined as the presence of: i. At least twelve and not more than forty inflammatory facial lesions (i.e., papules/pustules), AND ii. Subjects with a grade 3 or 4 on the 5-point Investigators Global Assessment (IGA) scale, AND iii. Persistent facial erythema (scored as at least mild on Erythema Severity Scale), AND iv. Facial telangiectasia (scored as at least mild on Telangiectasia Severity Scale.
• Subject willing to minimize external factors that might trigger rosacea flare-ups as recommended per protocol and patient instructional guide (e.g., spicy foods, thermally hot foods and drinks, hot environments, prolonged sun exposure, strong winds and alcoholic beverages).
• Non-nursing, female subjects of child bearing potential, who are using an acceptable form of birth control: total abstinence, oral (birth control pills), intravaginal: (e.g. NuvaRing®), implantable (e.g. Norplant®), injectable (e.g. Depo-Provera®) or transdermal (e.g. Ortho Evra®) contraception; intrauterine device (IUD); double-barrier (diaphragm or condom with spermicidal gel or foam); for two months prior to study enrollment or a vasectomized partner. All female subjects of child bearing potential must have undergone an in-office urine pregnancy test, with a negative result, prior to being randomized to receive study drug. In addition, women of childbearing potential must have agreed to a have urine pregnancy test at Day 42 and at the end of the study (Day 84). Females not of childbearing potential due to menopause must have been postmenopausal for at least one year. Male subjects must be willing to not attempt to conceive a child during the participation in the study. Females utilizing oral contraception must be willing to utilize an appropriate secondary form of contraception during the study.
• Subjects who use the same brand of soap, make-up, hair products, or shaving lotion/foam/cream/gel for a period of at least four weeks prior to the Baseline Visit and agree not to change these product brand/types during the study, with the exception of using the study approved cleanser and moisturizer with sunscreen provided by the sponsor.
• Male subjects who are willing to shave, if applicable, at approximately the same time every day.
• Subjects who are willing to refrain from sunbathing, using sun tanning booths/beds, or excessive exposure to the sun for the duration of the study.

Exclusion Criteria:

• Presence of any skin condition on the face that would interfere with the diagnosis or assessment of rosacea as determined by the Investigator.
• Excessive facial hair (e.g. beards, sideburns, moustaches, etc.) that would interfere with diagnosis or assessment of rosacea. Patients also must not grow excess facial hair during the study (i.e. they need to be free of excess facial hair for follow-up visits).
• History of hypersensitivity or allergy to minocycline, any other tetracycline or any other component of the formulation, or known reactions to cleansers, including Ponds Cold Cream, and moisturizer with sunscreen.
• Subjects using, or planning use of concomitant treatments within 30 days prior to Baseline visit (e.g., facial or chemical peels, dermal fillers, acne surgery, intralesional steroids, spironolactone, debridement, cryotherapy, dermabrasion, X-ray, IPL, laser therapy or UV therapy).
• Use within 6 months prior to baseline of oral retinoids (e.g. isotretinoin, acitretin) or therapeutic vitamin A supplements of greater than 10,000 International Units/day (multivitamins are allowed).
• Subjects using estrogens or progestin agents (e.g., Gynogen, Valergen, Depo-Testadiol, Depogen, birth control pills), for less than 2 months prior to the Baseline Visit. (Subjects using estrogens for 2 months or more are not excluded unless the subject expected to change dose, drug, or discontinue estrogen use during the study).
• Use within 2 month prior to the Baseline Visit of 1) topical retinoids to the face, 2) systemic antibiotics known to have an impact on the severity of facial rosacea (e.g., containing tetracycline and its derivatives, erythromycin and its derivatives, sulfamethoxazole, or trimethoprim, metronidazole), or 3) systemic corticosteroids.
• Use within 2 months prior to the Baseline Visit of 1) topical corticosteroids, 2) topical antibiotics or 3) topical medications for rosacea (e.g., metronidazole, azelaic acid, erythromycin, ivermectin, sulfur based topical products).
• Subjects with rhinophyma, dense telangiectasia, or plaque-like facial edema, more than 5 nodules or sinus tracts.
• Ocular rosacea (e.g., conjunctivitis, blepharitis, or keratitis) of sufficient severity to require topical or systemic antibiotics.
• Subjects with underlying diseases or other dermatological conditions, such as; atopic dermatitis, perioral dermatitis, or seborrheic dermatitis, which required the use of interfering topical or systemic therapy or may have interfered with the rosacea diagnosis.
• Subjects using an investigational drug or participating in an investigational study within 30 days of the Baseline Visit. Use of an investigational drug and/or participation in another investigational study prohibited during this study.
• Subjects who currently abuse alcohol or drugs or who have a history of chronic alcohol or drug abuse with in the past year.
• Medical history of immunodeficiency or other significant ongoing medical condition or disease as determined by the investigator.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Topical Vehicle Gel; Topical administration of vehicle gel. Regimen: Apply once daily, at bedtime to the face	Other: Topical Vehicle Gel; Treating Papulopustular Rosacea while monitoring for safety and efficacy of the vehicle intervention; Other Names: HY01 Topical Gel, 0%
Active Comparator: 1% Topical Minocycline Gel; Topical administration of 1% Topical Minocycline Gel. Regimen: Apply once daily, at bedtime to the face	Drug: 1% Topical Minocycline Gel; Treating Papulopustular Rosacea while monitoring for safety and efficacy of the active intervention; Other Names: HY01 Topical Gel, 1%
Active Comparator: 3% Topical Minocycline Gel; Topical administration of 3% Topical Minocycline Gel. Regimen: Apply once daily, at bedtime to the face	Drug: 3% Topical Minocycline Gel; Treating Papulopustular Rosacea while monitoring for safety and efficacy of the active intervention; Other Names: HY01 Topical Gel, 3%

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Lesion Count	Evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, as assessed by the change in inflammatory lesion count from baseline in patients with moderate-to-severe papulopustular rosacea	12 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Investigator's Global Assessment (IGA) Score	Evaluate the efficacy of once-daily application of 1% and 3% HY01 Topical Gel, in improving the Investigator's Global Assessment (IGA) scores from baseline over the 12-week treatment period in patients with moderate-to-severe papulopustular rosacea as defined as either a 2 point improvement from baseline or an improvement to "clear" or "almost clear" on the IGA	12 weeks

Collaborators and Investigators

• Sponsor: Hovione Scientia Limited
• Investigators: Principal Investigator: Sunil S Dhawan, MD, Center for Dermatology Clinical Research, Inc.

Study record dates

Study Major Dates

• Study Start (Actual): October 30, 2017
• Primary Completion (Actual): March 1, 2019
• Study Completion (Actual): July 1, 2019

Study Registration Dates

• First Submitted: August 24, 2017
• First Submitted That Met QC Criteria: August 25, 2017
• First Posted (Actual): August 28, 2017

Study Record Updates

• Last Update Posted (Actual): November 8, 2019
• Last Update Submitted That Met QC Criteria: November 6, 2019
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Keywords: Rosacea; Topical; Doxycycline; Minocycline; Tetracycline; Skin Disease; Anti-Inflammatory Agent; Anti-Bacterial Agent
• Additional Relevant MeSH Terms: Skin Diseases; Rosacea; Anti-Infective Agents; Anti-Bacterial Agents; Minocycline
• Other Study ID Numbers: HY01-003

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: Yes
• Studies a U.S. FDA-regulated device product: No