The Effects of Mood on Cerebral Perfusion

November 8, 2022 updated by: University Ghent
Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

48

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 30 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy university students
  • between 18 and 30 years old

Exclusion Criteria:

  • No informed consent
  • Not using hormonal contraception
  • MRI-contraindications
  • Claustrophobia
  • Pregnancy
  • Chronic diseases and chronic medication use

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: OTHER
  • Allocation: NA
  • Interventional Model: SINGLE_GROUP
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Imaging healthy volunteers
Mood induction: positive, negative, neutral mood (using subjects own memories) Arterial spin labeling MRI Physiological monitoring
Behavioral: Mood induction (using own memories)
Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI
Device: Arterial spin labeling MRI
Single PLD PCASL
Device: Physiological monitoring
During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Regional Cerebral perfusion (ml/100g/min) during positive mood induction
Time Frame: 2 minutes (ASL scan during mood state induction)
Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
2 minutes (ASL scan during mood state induction)
Regional Cerebral perfusion (ml/100g/min) during negative mood induction
Time Frame: 2 minutes (ASL scan during mood state induction)
Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
2 minutes (ASL scan during mood state induction)
Regional Cerebral perfusion (ml/100g/min) during neutral mood induction
Time Frame: 2 minutes (ASL scan during mood state induction)
Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
2 minutes (ASL scan during mood state induction)
Regional Cerebral perfusion (ml/100g/min) after positive mood induction
Time Frame: 2 minutes (ASL scan after mood state induction)
Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
2 minutes (ASL scan after mood state induction)
Regional Cerebral perfusion (ml/100g/min) after negative mood induction
Time Frame: 2 minutes (ASL scan after mood state induction)
Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
2 minutes (ASL scan after mood state induction)
Regional Cerebral perfusion (ml/100g/min) after neutral mood induction
Time Frame: 2 minutes (ASL scan after mood state induction)
Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
2 minutes (ASL scan after mood state induction)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Ghent

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

January 8, 2016

Primary Completion (ACTUAL)

October 30, 2017

Study Completion (ACTUAL)

November 17, 2017

Study Registration Dates

First Submitted

October 6, 2016

First Submitted That Met QC Criteria

September 29, 2017

First Posted (ACTUAL)

October 4, 2017

Study Record Updates

Last Update Posted (ACTUAL)

November 14, 2022

Last Update Submitted That Met QC Criteria

November 8, 2022

Last Verified

November 1, 2022

More Information

Terms related to this study

Other Study ID Numbers

  • EC/2015/0528

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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