- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03318510
LSFG in Patients With Normal Tension Glaucoma Tension Glaucoma
October 19, 2017 updated by: Matthias Bolz, Augenabteilung Allgemeines Krankenhaus Linz
Laser Speckle Flowgraphy in Patients With Normal Tension Glaucoma - a Pilot Study
Glaucoma is the second leading cause of blindness worldwide.
Literature shows increasing evidence that dysfunction of ocular microcirculation in the optic nerve influences the progression of glaucoma.
Laser speckle flowgraphy (LSFG) represents a non-invasive method to quantify ocular perfusion also at the ONH.
LSFG enables noninvasive quantification of microcirculation of the optic disc in Japanese glaucoma patients
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
40
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Oberösterreich
-
Linz, Oberösterreich, Austria, 4021
- AKH Linz
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
50 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Caucasian men and women aged over 50 years
- Subject is generally healthy with no current significant or a history of a significant neurological, cardiovascular, pulmonary (including asthma), hepatic, metabolic, rheumatic, autoimmune, hematological or renal disorder, as determined by the investigator's clinical judgment through collection of medical history and performance of a physical examination. A significant disorder is defined as a disease or medical condition associated with impaired health status, requiring regular or current medical treatment and/or follow up. For the purposes of this study, an investigator may classify a medical condition as a nonsignificant disorder despite the fact that the subject receives treatment. Subjects having controlled Stage 1 hypertension (blood pressure of 140-159 mmHg systolic and/or 90-99 mmHg diastolic) are eligible for participation in this study
- Normal open angle in a gonioscopic examination
- Presence of glaucomatous optic disc changes in biomicroscopy and
- Visual field defects in at least two visual field examinations (Reliability criteria: fixation errors < 20%, false positives < 15%, and false negatives < 33%) Or
- Abnormal circumpapillary retinal nerve fiber layer thinning (RNFL evaluated by OCT)
Exclusion Criteria:
- History of ocular or systemic disease causing optic nerve damage
- History of IOP greater than 21 mm Hg (corrected by CCT)
- Participation in a clinical trial in the 3 weeks preceding the study
- Ocular surgery (including intravitreal injection) during the 3 months preceding the study
- Ametropia > 6 Dpt
- Smoking
- pre- or perimenopausal women
- Relevant ophthalmic diseases/conditions that could interfere with LSFG measurements (e.g. optic nerve head drusen, tilted disc, etc.)
- Opacities of the cornea (e.g. corneal scars, corneal oedema), the lens (e.g. LOCS-II grading > 2, posterior capsule opacification) or the vitreous (e.g. vitreous haemorrhage, asteroid hyalosis)
- Patients who are not able to cooperate or with insufficient ability to fixate (tremor, nystagmus)
- Blood donation in the 3 weeks preceding the study
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- Ocular infection or clinically significant inflammation
- Pregnancy, planned pregnancy or lactating
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Mean blur ratio (LSFG)
Time Frame: 4 seconds
|
4 seconds
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Pulse-waveform parameters (LSFG)
Time Frame: 4 seconds
|
4 seconds
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2017
Primary Completion (Anticipated)
November 20, 2017
Study Completion (Anticipated)
December 1, 2017
Study Registration Dates
First Submitted
October 19, 2017
First Submitted That Met QC Criteria
October 19, 2017
First Posted (Actual)
October 24, 2017
Study Record Updates
Last Update Posted (Actual)
October 24, 2017
Last Update Submitted That Met QC Criteria
October 19, 2017
Last Verified
October 1, 2017
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- AO Form 01-05/1.0
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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