- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03348228
Effect of Hydroxycitrate on Urine Chemistry
January 11, 2022 updated by: NYU Langone Health
Hydroxycitrate (HCA) is a compound extracted from the fruit, Garcinia Cambogia.
Hydroxycitrate supplements are available over the counter and are primarily promoted as a weight loss supplement.
There has been recent evidence that hydroxycitrate is a potent inhibitor of calcium oxalate crystal growth and can lead to the dissolution of the crystals.
The purpose of this research study is to study the effect of Hydroxycitrate (HCA) supplements on HCA urinary excretion and on urine chemistries in kidney stone formers and normal subjects.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
18
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
New York
-
New York, New York, United States, 10016
- New York University School of Medicine
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Stone formers group:
- Established diagnosis of recurrent calcium stone formers
- Ages between 18 and 80
- Subjects must be able to read and follow instructions clearly and able to do 24 hour urine collections.
- Subjects must be voluntarily willing and able to sign an informed consent form.
Control Group:
- In addition to b, c and d above, subjects must not have any known kidney disease or family history of renal stones. Inclusion would be based on information provided by participants.
Exclusion Criteria:
-
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Placebo Comparator: Control Group
Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet.
HCA will be administered afterwards to both groups (see methods below) for 7 days
|
Hydroxycitrate supplements are available over the counter and are primarily promoted as a weight loss supplement.
Each subject will be given 42 capsules of Swanson super citrimax (hydroxycitrate) Details of the product are provided above.
The subjects will be asked to take the capsules over a seven period (6 capsules per day).
|
Active Comparator: Calcium Stone Formers
Participants willrecord a self-selected diet for 3 days and then perform two 24-hour urine collections on the last 2 days of this diet.
HCA will be administered afterwards to both groups (see methods below) for 7 days
|
Hydroxycitrate supplements are available over the counter and are primarily promoted as a weight loss supplement.
Each subject will be given 42 capsules of Swanson super citrimax (hydroxycitrate) Details of the product are provided above.
The subjects will be asked to take the capsules over a seven period (6 capsules per day).
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
changes in urinary excretion of citrate
Time Frame: 7 Days
|
Paired t-tests will be performed to compare any changes in citrate before and after the intervention.
|
7 Days
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 4, 2018
Primary Completion (Actual)
December 15, 2020
Study Completion (Actual)
December 15, 2020
Study Registration Dates
First Submitted
November 15, 2017
First Submitted That Met QC Criteria
November 15, 2017
First Posted (Actual)
November 20, 2017
Study Record Updates
Last Update Posted (Actual)
January 26, 2022
Last Update Submitted That Met QC Criteria
January 11, 2022
Last Verified
January 1, 2022
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 17-00147
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Undecided
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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