Antibiotic Footprint Thailand - Pilot Questionnaire Study (AFT PILOT)

Antimicrobial-resistant bacterial infection is an important cause of death in Thailand and in other countries worldwide. Increasing use of antibiotics in both animals and humans is one of the main drive that increase the incidence of antimicrobial resistant bacteria in human, animals and environment.

National Action Plan for Combating Antibiotic-resistant Bacteria aimed to have general population taking antibiotics less than 20% when they have common cold or diarrheal symptoms. However, there is little accurate information about behaviors of Thai people. Most studies were conducted in hospitals, clinics or pharmacy. Therefore, it did not include behaviors of those who had symptoms but did not present at hospitals, clinics or pharmacy.

In this study, the investigators aim to use questionnaire to Thai adult population to ask for the the amount of antibiotic used and the periods they had symptoms of common cold or diarrhea over one year period of year 2017. The main aim is to estimate the total antibiotic usage per human population, and plan for the study in the future.

Study Overview

• Status: Completed
• Conditions: Antibiotic Usage
• Intervention / Treatment: Other: Obtain inform consent via questionnaire of Monkey Survey

• Study Type: Observational
• Enrollment (Actual): 237

Contacts and Locations

Study Locations

• Thailand
  • Bangkok, Thailand, 10400
    • Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol university, Thailand

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

This study aims to have at least 100 adult people who could provide information for the total of one year. This expects that at least 20 of those 100 people would have common cold or diarrhea at least one time over one year period. This should provide more than 80% power to detect whether the proportion of having antibiotics when they have common cold or diarrhea was lower than 50% or not. The hypothesizjed proportion was 20% as stated by the national strategy against AMR in Thailand.

MORU has a total number of staff for more than 200 people, and we suspect that the internal people in MORU should be enough for the study. We will also want to pilot whether the internet-based study can spread into the community well or not.

Description

Inclusion Criteria:

The participant may enter the study if ALL of the following apply:

1. Participant is willing and able to give informed consent for participation in the study.
2. Male or female, aged 18 years or above.
3. Living in Thailand (staying in Thailand more than 6 months per year)

Exclusion Criteria:

None

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

Contact group email of Mahidol-Oxford Research Unit (MORU); The investigator aims to have at least 100 adult people who could provide information for the total of one year. This expects that at least 20 of those 100 people would have common cold or diarrhea at least one time over one year period. This should provide more than 80% power to detect whether the proportion of having antibiotics when they have common cold or diarrhea was lower than 50% or not. The hypothesized proportion was 20% as stated by the national strategy against AMR in Thailand

Other: Obtain inform consent via questionnaire of Monkey Survey; This is an internet-based questionnaire study. Therefore, anyone in Thailand can access and answer the questionnaire.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Total antibiotic usage in human population	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Association between the antibiotic usage and the episodes of common cold	Association between the antibiotic usage and the episodes of common cold or diarrhea in Thai adult population	1 year
Association between the antibiotic usage and the episodes of diarrhea	Association between the antibiotic usage and the episodes of common cold or diarrhea in Thai adult population	1 year

Collaborators and Investigators

• Sponsor: University of Oxford

Study record dates

Study Major Dates

• Study Start (ACTUAL): February 8, 2017
• Primary Completion (ACTUAL): March 30, 2018
• Study Completion (ACTUAL): March 30, 2018

Study Registration Dates

• First Submitted: October 30, 2017
• First Submitted That Met QC Criteria: December 4, 2017
• First Posted (ACTUAL): December 11, 2017

Study Record Updates

• Last Update Posted (ACTUAL): August 15, 2018
• Last Update Submitted That Met QC Criteria: August 14, 2018
• Last Verified: August 1, 2018

More Information

Terms related to this study

• Keywords: Antimicrobial-resistant bacterial infection; Questionaire
• Other Study ID Numbers: MICRO1704

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No