Comprehensive Assessment of Neurodegeneration and Dementia

The Comprehensive Assessment of Neurodegeneration and Dementia Study

Sponsors

Lead Sponsor: McGill University

Collaborator: Canadian Institutes of Health Research (CIHR)
Alzheimer Society of Canada
Sanofi
New Brunswick Health Research Foundation
Saskatchewan Health Research Foundation
Women's Brain Health Initiative
Michael Smith Foundation for Health Research
Alzheimer's Research UK
Alberta Prion Research Institute
Nova Scotia Health Research Foundation
Eli Lilly and Company
Canadian Nurses Foundation (CNF)
Ontario Brain Institute
Consortium pour l'Identification precoce du Maladie Alzheimer du Quebec
Pfizer
Canadian Consortium on Neurodegeneration in Aging

Source McGill University
Brief Summary

This is a 5-year observational study recruiting sixteen hundred and fifty individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group of six hundred and fifty aged matched individuals without cognitive deficits. Participants will be recruited at sites across Canada and will undergo assessments and provide biological samples at baseline and two years after baseline.

Detailed Description

This is a 5-year observational study. Sixteen-hundred and fifty (1650) subjects, between the ages of 50 and 90,years old, with Subjective Cognitive Impairment, Mild Cognitive Impairment, Mild Cognitive Impairment with subcortical vascular lesions, Alzheimer's Disease, Mixed dementia, Lewy Body Dementia, Parkinson's Disease Dementia, Parkinson's Disease with Mild Cognitive Impairment and Frontotemporal Dementia, as well as 650 healthy elderly subjects without cognitive complaints or deficits, will be enrolled into this study from up to 30 centres across Canada. All subjects involved in the study will undergo rigorous evaluations at baseline, including clinical assessment, neuropsychological assessment, genomics and neuroimaging. Biological samples from blood, saliva, urine, fecal matter, buccal cells and cerebrospinal fluid will be collected, stored, and analyzed. Basic follow-up determining if there has been any change in their diagnosis will be carried out annually and longitudinal re-evaluation will be carried out after two years.

Overall Status Recruiting
Start Date June 2016
Completion Date September 2023
Primary Completion Date September 2023
Study Type Observational
Primary Outcome
Measure Time Frame
Montreal Cognitive Assessment (MoCA) score 2 years
Enrollment 2300
Condition
Eligibility

Sampling Method: Non-Probability Sample

Criteria:

Inclusion Criteria:

- Has subjective or objective cognitive impairment

- Written informed consent must be obtained and documented (from the patient or, where jurisdictions allow it, from a caregiver/family member)

- Sufficient proficiency in English or French to undertake self report and neuropsychological testing

- Geographic accessibility to the study site

- Must have a study partner who can participate as required in the protocol (provide corroborative information)

Exclusion Criteria:

- The presence of other significant known chronic brain disease such as: moderate to severe chronic static leukoencephalopathy (including previous traumatic injury), multiple sclerosis, a serious developmental handicap, malignant tumors, Parkinson's disease (other than for the Parkinson's/Lewy Body Dementia cohort), and other rarer brain illnesses

- Ongoing alcohol or drug abuse which in the opinion of the investigator may interfere with the subject's ability to comply with the study procedures

- Symptomatic stroke within the previous year

- MoCA < 13

- Unable to undergo MRI scan due to medical contraindications or inability to tolerate the procedure

Gender: All

Minimum Age: 50 Years

Maximum Age: 90 Years

Healthy Volunteers: Accepts Healthy Volunteers

Overall Official
Last Name Role Affiliation
Michael Borrie, MD Study Director Western University
Overall Contact

Last Name: Howard Chertkow, MD

Phone: 514 340 8222

Phone Ext.: 25129

Email: [email protected]

Location
Facility: Status: Contact: Contact Backup:
Foothills Medical Centre | Calgary, Alberta, T2N 2T9, Canada Recruiting Eric E Smith, MD 403.944.1594 [email protected]
University of Alberta Hospital | Edmonton, Alberta, T6G 2B7, Canada Recruiting Richard Camicioli, MD (780) 248-1774 [email protected]
University of Northern British Columbia | Prince George, British Columbia, V2N 4Z9, Canada Not yet recruiting Jacqueline Pettersen, MD 250-960-5414 [email protected]
Vancouver Coastal Health Research Institute | Vancouver, British Columbia, V5Z 1M9, Canada Recruiting Teresa Liu-Ambrose, PhD 604.875.4111 69059 [email protected]
Djavad Mowafaghian Centre for Brain Health | Vancouver, British Columbia, V6T 1Z3, Canada Recruiting Robin Hsiung, MD 604-822-3610 [email protected]
Island Health | Victoria, British Columbia, V8R 6R3, Canada Not yet recruiting Alexandre Henri-Bhargava, MD (778) 265-6111 [email protected]
St. Joseph's Hospital | Saint John, New Brunswick, E2L 3L6, Canada Recruiting Pamela Jarrett, MD 506-632-5556 [email protected]
Hamilton General Hospital | Hamilton, Ontario, L8L 2X2, Canada Recruiting Demetrios Sahlas, MD 905-521-2100 46373 [email protected]r.ca
London Health Sciences Centre | London, Ontario, N6A 5A5, Canada Recruiting Penny MacDonald, MD (519) 663-3631 [email protected]
Cognitive Clinical Trials Group | London, Ontario, N6C 0A7, Canada Recruiting Michael Borrie, MD (519) 685-4021 0 [email protected]
Cognitive Neurology & Alzheimer's Research Centre | London, Ontario, N6C 0A7, Canada Not yet recruiting Elizabeth Finger, MD 519-646-6032 [email protected]
Gait and Brain Lab | London, Ontario, N6C 5J1, Canada Recruiting Manuel Montero-Odasso, MD 519.685.4292 42369 [email protected]
Bruyère Research Institute | Ottawa, Ontario, K1N 5C8, Canada Recruiting Stephanie Yamin, PhD 613-236-1393 2380 [email protected]
Kawartha Centre | Peterborough, Ontario, K9H 2P4, Canada Recruiting Jennifer Ingram, MD 705-749-3906 [email protected]
The Centre for Memory and Aging | Toronto, Ontario, M4G 3E8, Canada Recruiting Giovanni Marotta, MD 416-663-6897 [email protected]
Sunnybrook Health Sciences Centre | Toronto, Ontario, M4N 3M5, Canada Recruiting Sandra E Black, MD 416-480-4551 [email protected]
University Health Network Memory Clinic | Toronto, Ontario, M5T 2S8, Canada Recruiting Carmela Tartaglia, MD 416-507-6879 [email protected]
Baycrest | Toronto, Ontario, M6A 2E1, Canada Recruiting Nicole Anderson, PhD (416)785-2500 3366 [email protected]
Sun Life Financial Movement Disorders and Rehabilitation Centre | Waterloo, Ontario, N2L 3C5, Canada Recruiting Quincy Almeida, PhD 519 884 0710 2840 [email protected]
University of Waterloo | Waterloo, Ontario, N2L 3G1, Canada Recruiting Middleton Laura, Ph.D. 519-888-4567 33045 [email protected]
Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM) | Montréal, Quebec, H2X 3H8, Canada Recruiting Josée Filion, MD 514 890-8000 [email protected]
Research Institute of the McGill University Health Centre | Montréal, Quebec, H3G 1A4, Canada Active, not recruiting
Jewish General Hospital/McGill Memory Clinic | Montréal, Quebec, H3T 1E2, Canada Recruiting Susan Vaitekunas, MD 514 340 8222 24734 [email protected]
Clinique de cognition Institut universitaire de gériatrie de Montréal | Montréal, Quebec, H3W 1W5, Canada Recruiting Marie-Jeanne Kergoat, MD 514 340-3540 2811 [email protected]
Douglas Mental Health University Institute Memory clinic | Montréal, Quebec, H4H 1R3, Canada Recruiting Vasavan Nair, MD 514 762-3035 [email protected]
McGill University Research Centre for Studies in Aging | Montréal, Quebec, H4H 1R3, Canada Recruiting Serge Gauthier, MD 514-766-2010 [email protected]
Clinique interdisciplinaire de mémoire (CIME) | Québec City, Quebec, G1J 1Z4, Canada Recruiting Louis Verret, MD 418-649-5980 [email protected]
Centre de recherche sur le vieillissement CIUSSS de l'Estrie-CHUS | Sherbrooke, Quebec, J1J3H5, Canada Recruiting Tamas Fulop, MD 819 780-2220 45293 [email protected]
Royal University Hospital | Saskatoon, Saskatchewan, S7N 0W8, Canada Recruiting Andrew Kirk, MD 306-844-1421 [email protected] Alex Rajput, MD Sub-Investigator
Location Countries

Canada

Verification Date

September 2019

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Arm Group

Label: Normal healthy elderly

Description: participants with no subjective or objective cognitive deficits or decline.

Label: Subjective Cognitive Decline

Description: Participants with a complaint of subjective cognitive impairment, but no objective evidence of such.

Label: Mild Cognitive Impairment (MCI)

Description: Participants with objective evidence of cognitive impairment, but it does not impact on daily function.

Label: Vascular MCI

Description: Participants meeting criteria of MCI who also show signs of cerebrovascular disease on imaging but have no history of stroke.

Label: Alzheimer's Disease

Description: Participants with dementia of the Alzheimer's type according to the National Institute of Aging-Alzheimer's Association criteria

Label: Dementia of Mixed Etiology

Description: Participants with dementia and evidence of more than one etiology.

Label: Lewy Body/Parkinson's spectrum

Description: Participants with Parkinson's disease who show mild or moderate cognitive impairment and/or dementia.

Label: Frontotemporal dementia (FTD) spectrum

Description: Participants with behavioral variant FTD, primary progressive aphasia, progressive supranuclear palsy, or corticobasal syndrome

Acronym COMPASS-ND
Patient Data Yes
Study Design Info

Observational Model: Cohort

Time Perspective: Prospective

Source: ClinicalTrials.gov