Influence of Daily Activities on Retinal Microcirculation

February 21, 2022 updated by: Jiannan Huang

The Influence of Daily Activities on Retinal Microcirculation in Normal Adults

The daily behaviors such as drinking coffee, wine, reading, exercise and body postural changes may have influence on the function or morphology of the retinal microcirculation in healthy people.A recent study found that the fingertips microvascular bed constricted obviously after the intake of a cup of coffee with caffeine, it significantly reduced blood flow to the fingers; Long reading of electronic products can induce significant dry eye symptoms, affect visual quality, and cause asthenopia. Microcirculation is critical for regulating vascular resistance and blood flow in organs. Fundus blood vessels is the only visible microvascular in vivo, its morphology and function changes not only associated with eye disease, but also with cardiovascular and cerebrovascular diseases. Optical coherence tomography angiography (OCTA) is a new technique which could acquire blood flow information in a non-invasive way without the use of dye. Magnetic resonance imaging (MRI) can quantitatively evaluation of cerebral blood flow and retina-choroid blood flow using the noninvasive arterial spin labeling technique in a large field of view (FOV) without depth limitations.The study tried to detect the influence of daily behaviors such as drinking coffee, red wine, reading ,and exercise on the retinal microcirculation with OCTA and MRI, and provide reference for health behaviors.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

54

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Shanghai
      • Shanghai, Shanghai, China, 200040
        • Shanghai Eye Disease Prevention & Treatment Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 25 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria

  1. Healthy adults
  2. The age range was from 18 to 25 years old
  3. Without another eye disease besides ametropia
  4. The spherical equivalent is equal or above minus 3.00 diopters
  5. No smoking or drinking
  6. Average daily caffeine consumption no more than 1 cup of coffee
  7. No diabetes, hypertension, heart disease, liver or kidney dysfunction
  8. No medication taken recently

Exclusion Criteria

  1. Mental disorders such as depression and anxiety
  2. Intellectual disabilities
  3. Female in menstruation, gestation period, perinatal period or lactation period
  4. Unable to cooperate with eye examinations and test procedures
  5. Heart disease, hypertension, diabetes, liver and kidney dysfunction and other chronic diseases
  6. Patients with fever, acute infectious diseases
  7. Other conditions that are not suitable for drinking alcohol or coffee, such as allergic to alcohol or coffee

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Beverage consumption
Drink 300ml red wine (alcohol concentration:12.5%), 300ml coffee (caffeine concentration 72 mg), or 300ml water.
Behavioral: Beverage consumption
The participants drink 300ml wine (alcohol concentration:12.5%)or 300ml coffee (caffeine concentration 72 mg), or water.
EXPERIMENTAL: Daily reading
Reading paper books, playing video games with mobile phones, or non-reading.
Behavioral: Daily reading
Reading paper books, playing video games with mobile phones, or non-reading for 8 hours.
EXPERIMENTAL: Body motion
Exercise and body postural changes.
Behavioral: Body motion
Exercise or body postural changes

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Vessel diameter index (VDI)
Time Frame: 3 weeks
VDI is calculated using both the vessel area map and the skeletonized vessel map, to yield the averaged vessel caliber.
3 weeks
Vessel area density (VAD)
Time Frame: 3 weeks
VAD is calculated as a unit-less ratio of the total image area occupied by the vasculature to the total image area in the binary vessel maps.
3 weeks
Flow impairment region (FIR)
Time Frame: 3 weeks
FIZ: calculated by summing all 'no-flow' pixels up.
3 weeks
Retina-choroid blood flow
Time Frame: 3 weeks
Blood flow for the entire retinal thickness were determined as a function of the distance from the optic nerve head, where the blood flow was measured at the peaks of the projection profiles. An region of interest outlining the posterior retina with a size of 0.7 to 0.8 mm across the retina-choroid thickness in the parafoveal region was used to obtain the blood flow signal time courses and averaged the values.
3 weeks
Cerebral blood flow (CBF)
Time Frame: 3 weeks
The frontal lobe was selected as the region of interest (ROI) to measure and average the changes in CBF
3 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Jiannan Huang

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

May 1, 2017

Primary Completion (ACTUAL)

October 31, 2020

Study Completion (ACTUAL)

December 31, 2020

Study Registration Dates

First Submitted

January 17, 2018

First Submitted That Met QC Criteria

January 23, 2018

First Posted (ACTUAL)

January 30, 2018

Study Record Updates

Last Update Posted (ACTUAL)

March 9, 2022

Last Update Submitted That Met QC Criteria

February 21, 2022

Last Verified

February 1, 2022

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • YFZX2017001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

No plan to share individual participant data because of personal privacy.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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