- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03600532
Teachable Moment Brief Intervention for Suicide Attempt Survivors in an Inpatient Setting (TMBI-IP)
August 12, 2019 updated by: University of Tulsa
Testing the Efficacy of the Teachable Moment Brief Intervention for Suicide Attempt Survivors in an Inpatient Setting: Effects on Psychosocial and Experimental Pain Outcomes
This study is looking at the helpfulness of a brief treatment targeting suicidality (Teachable Moment Brief Intervention [TMBI]) and experimental pain responses in an inpatient population as well as collecting comparison data from the community.
Study Overview
Status
Terminated
Conditions
Intervention / Treatment
Detailed Description
The proposed study will use an innovative one-session psychotherapeutic intervention called the Teachable Moment Brief Intervention (TMBI) for suicide attempters admitted to a psychiatric inpatient unit.
A total of 60 patients will be recruited from the inpatient psychiatry unit at Laureate Psychiatric Clinic and Hospital and 30 healthy community members for the study.
Informed consent will be obtained for all participants and administration of the baseline assessment battery will be completed prior to randomization for patients.
Patients will then be randomized to either (a) an experimental group receiving TMBI or (b) a group receiving treatment as usual (TAU).
The intervention will consist of no more than 90 minutes (expected mean is 45 minutes for the intervention based upon previous studies of the TMBI) of 1:1 interaction with a study clinician.
All participants will complete a follow-up assessment immediately following TMBI, TAU, or a rest period.
Further, patients receiving the experimental intervention will then be asked to complete a client satisfaction survey.
The aim will be to assess whether TMBI affects psychological, experimental pain, and autonomic nervous system responses as compared to TAU and community controls.
Study Type
Interventional
Enrollment (Actual)
7
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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Oklahoma
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Tulsa, Oklahoma, United States, 74136
- Laureate Psychiatric Clinic and Hospital
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Tulsa, Oklahoma, United States, 74104
- University of Tulsa, Psychophysiology Laboratory for Affective Neuroscience (PLAN)
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
TMBI & TAU (data collection at Laureate Psychiatric Clinic and Hospital [LPCH])
Inclusion:
-admitted to LPCH subsequent to a suicide attempt
Exclusion:
- acute psychosis,
- inability to read English, or
- taking narcotic or opioid pain medication
CCG (data collection in the Psychophysiology Laboratory for Affective Neuroscience [PLAN] on the University of Tulsa campus)
Exclusion:
- acute psychosis,
- current suicide ideation,
- history of self-harm,
- inability to read English, or
- taking narcotic or opioid pain medication
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Teachable Moment Brief Intervention
The TMBI is informed by evidence based strategies to collaboratively identify 1) drivers of suicidal ideation, 2) functional aspects of the recent suicide attempt, 3) the patient's relationship with the concept of suicide, 4) what has been lost and gained as a result of the suicide attempt, 5) short term management suicide prevention management strategies, and 6) documentation of factors to address in a suicide-specific treatment plan.
|
Behavioral intervention informed by Collaborative Assessment and Management of Suicidality and Dialectical Behavior Therapy/Cognitive Behavior Therapy to assist in positive recovery trajectory following a suicide attempt.
|
NO_INTERVENTION: Treatment as Usual (TAU)
Usual care at Laureate Psychiatric Clinic and Hospital Adult Stabilization Unit who have attempted suicide involves psychiatric evaluation/treatment and ongoing medical stabilization.
Patients will engage in usual care or a rest period before completing the post-assessment.
|
|
NO_INTERVENTION: Community Control Group (CCG)
Patients will engage in a rest period before completing the post-assessment.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in Beck Scale for Suicide Ideation
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
19-item assessment used to evaluate the current intensity of the patient's specific attitudes toward, behavior, and plans to commit suicide.
Total score will be reported which ranges from 0 (no suicidal ideation) to 38 (high suicidal ideation).
|
Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes in Stages of Change Questionnaire
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
18-item measure that measures motivation to engage in treatment/work on problems.
Total score will be summed from all items, with range from 18 (low motivation) to 90 (high motivation).
Four subscales will also be reported as follows: Precontemplation ranges from 5 (low) to 25 (high) with higher scores indicating higher motivation.
Contemplation ranges from 4 (low) to 20 (high) with higher scores indicating higher motivation.
Action ranges from 5 (low) to 25 (high) with higher scores indicating higher motivation.
Maintenance ranges from 4 (low) to 20 (high) with higher scores indicating higher motivation.
|
Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Changes in Reasons for Living Inventory
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
48-item measure that rates the importance of different reasons why people choose not to kill themselves.
Total score will be reported, which ranges from 48 (low reasons for living) to 288 (High reasons for living).
|
Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Changes in Adult State Hope Scale
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
6-item measure of ongoing self-directed thinking.
Total score will be reported, which ranges from 6 (low hope) to 48 (high hope).
|
Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Change in Positive and Negative Affect Schedule
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
20-item self-report measure of Positive (PANAS-PA; 10 items) and Negative (PANAS-NA; 10 items) Affect.
Each PANAS emotion word is rated on a 5-point scale, 1 (very slightly) to 5 (extremely) corresponding to the extent to which each emotion is experienced at the time of administration.
Thus, higher scores indicate more and/or stronger positive (PANAS-PA) or negative (PANAS-NA) emotions.
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Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Changes in Ischemic Pain Outcomes
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Ischemia produces a pain akin to clinical musculoskeletal pain syndromes.
120 handgrip exercises will be conducted at a rate of 1/sec at 50% maximal effort using a dynamometer (handgrip force meter), and then the arm will be raised to promote exsanguination.
A blood pressure cuff will then be inflated around the arm biceps to 220 mm/Hg to produce ischemia.
The participants will be instructed to inform the experimenter when they first experience pain (pain threshold).
The cuff will be deflated when the pain is no longer tolerable or after 3 minutes (pain tolerance).
After 3 minutes as measured by a stopwatch (or when the participant discontinues the task), they will be asked to rate the average and peak pain intensity during the task on a scale from 0 (no pain) to 100 (intolerable pain).
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Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Changes in Mechanical Pressure Pain Outcomes
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Delivered using von Frey hairs (i.e., monofilament = brush with only one bristle) on the back of the nondominant hand.
The monofilament, sized 6.45, will be applied to the skin at a 90 degree angle, which exerts 180 grams of force.
The participant will be asked to rate their pain on a scale of 0 (no pain) to 100 (intolerable pain).
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Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Changes in Temporal Summation of Pain
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Delivered using von Frey hairs (i.e., monofilament = brush with only one bristle) on the back of the nondominant hand.
The 6.45 monofilament will be applied to the skin at a 90 degree angle 10 times, once per second.
The participant will be asked to rate their peak pain during these 10 stimuli on a scale of 0 (no pain) to 100 (intolerable pain).
Temporal summation is the extent by which pain experience increases over the course of repeated stimulus presentation.
Therefore, it will be measured as the difference between the peak pain over the course of these 10 stimuli and the rating of the single stimulus (mechanical pressure pain).
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Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Changes in Skin Conductance Level
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Sympathetic arousal will be measured from skin conductance level (SCL), measured from a BioDerm meter (UFI Model 2701) and corresponding electrodes filled with isotonic paste and placed on the volar surface of the medial digit on the index and middle fingers of the left hand.
SCL will be assessed during the resting BP measurement prior to any testing, for one minute prior to pain testing during the BP measurement, during pain testing, and for one minute following pain testing during the second BP measurement.
SCL will be recorded every 15 seconds manually by the experimenter.
A pain-related change score will be created to find the difference between the average SCL during baseline and during pain testing.
A recovery-related change score will be created to find the difference between average SCL during pain testing and the average post pain testing SCL.
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Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Changes in Blood Pressure
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
|
Resting systolic and diastolic blood pressure (BP) will be measured using a medical blood pressure monitor prior to testing.
BP will also be measured just prior to and immediately following the pain testing.
BP will be measured on the right arm.
A pain-related change score will be created to find the difference between the BP before and after pain testing.
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Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Changes in Cardiovascular Measurements
Time Frame: Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Resting heart rate (HR; e.g., beats per minute [BPM]) will be measured using a medical blood pressure monitor prior to testing.
HR will also be measured just prior to and immediately following the pain testing.
HR will be measured on the right arm.
A pain-related change score will be created to find the difference between the HR before and after pain testing.
|
Assessed immediately before the intervention or rest period (baseline) and immediately after the intervention or rest period (approximately 1 hour from baseline)
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Cassandra A Sturycz, MA, University of Tulsa
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
July 1, 2018
Primary Completion (ACTUAL)
July 1, 2019
Study Completion (ACTUAL)
July 1, 2019
Study Registration Dates
First Submitted
July 3, 2018
First Submitted That Met QC Criteria
July 16, 2018
First Posted (ACTUAL)
July 26, 2018
Study Record Updates
Last Update Posted (ACTUAL)
August 14, 2019
Last Update Submitted That Met QC Criteria
August 12, 2019
Last Verified
August 1, 2019
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- TU1808
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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