Progression of Prodromal Markers of α-synucleinopathy Neurodegeneration in the FDRs of Patients With RBD
Progression of Prodromal Markers of α-synucleinopathy Neurodegeneration in the First-degree Relatives of Patients With REM Sleep Behavior Disorder: a 5-year Prospective Study
Lead Sponsor: Chinese University of Hong Kong
|Source||Chinese University of Hong Kong|
This study is a prospective study with a mean of 5-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development of clinical disorders in first-degree relatives (FDRs) of idiopathic REM Sleep Behavior Disorder (RBD) patients and healthy controls.
Idiopathic RBD is implicated as an integral part of progression of α-synucleinopathy neurodegeneration, and patients with idiopathic RBD have increased prevalence of non-motor symptoms (or prodromal markers) closely related to Parkinson's disease(PD). Moreover, the investigator's previous studies have further confirmed the familial aggregation of RBD, and first-degree relatives (FDRs) of RBD patients had more prodromal markers of Parkinson's disease compared with FDRs of healthy controls.
In these regards, current prospective study aims to map the progression and evolution of prodromal markers (including autonomic dysfunction, olfactory loss, color vision impairment, neurocognitive impairment, neuroimaging of dopamine dysfunction, daytime sleepiness and psychiatric disorders), onset of RBD, and neurodegenerative diseases. Finally, other markers, such as physical activity and circadian rhythm and tonic electromyography (EMG) activity level, which have been found to be reliably associated with Parkinson's disease or other neurodegenerative diseases. In this regard, it is also interesting to investigate whether these indicators will additionally predict the progression of prodromal markers of PD.
|Start Date||September 27, 2018|
|Completion Date||August 31, 2021|
|Primary Completion Date||August 31, 2021|
Sampling Method: Non-Probability Sample
Inclusion Criteria: 1. Chinese aged 40 or above; 2. Being capable of giving informed consent for participation of the study; 3. Sex-matched. Exclusion Criteria: 1. Younger than 40 years old (as the supposed neurodegenerative process may not have occurred); 2. Not capable of giving informed consent for participation of the study.
1. Chinese aged 40 or above;
2. Being capable of giving informed consent for participation of the study;
1. Younger than 40 years old (as the supposed neurodegenerative process may not have occurred);
2. Not capable of giving informed consent for participation of the study.
Minimum Age: 40 Years
Maximum Age: N/A
Healthy Volunteers: Accepts Healthy Volunteers
Last Name: Jihui Zhang, PhD
Email: [email protected]
Type: Principal Investigator
Investigator Affiliation: Chinese University of Hong Kong
Investigator Full Name: Dr. Zhang Jihui
Investigator Title: Assistant Professor
|Has Expanded Access||No|
Label: FDRs of idiopathic RBD patients
Description: First-degree relatives of idiopathic RBD patients
Label: FDRs of controls
Description: First-degree relatives of controls
|Study Design Info||
Observational Model: Case-Control
Time Perspective: Prospective