- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03850860
Comparison of Two Empirical Antimicrobial Therapies of Prosthetic Joint Infection
September 21, 2023 updated by: Eugénie MABRUT, Hospices Civils de Lyon
Comparison of the Tolerance of Vancomycin in Combination With Piperacillin/Tazobactam or Cefepim as Empirical Antimicrobial Therapy of Prosthetic Joint Infection
The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI).
However, the tolerability of such high-dose intravenous regimens is poorly known.
T
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
The empirical use of vancomycin in combination with a broad-spectrum beta-lactam is currently recommended after the initial surgery of prosthetic joint infection (PJI).
However, the tolerability of such high-dose intravenous regimens is poorly known.
The empirical antimicrobial therapy of PJI is associated with an important rate of adverse, linked with the use of the vancomycin and the piperacillin-tazobactam combination.
Some studies suggest to use vancomycin-cefepime, which remains to be evaluated in PJI.
Study Type
Observational
Enrollment (Actual)
178
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Lyon, France, 69004
- Hospices Civils de Lyon
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 100 years (Adult, Older Adult)
Accepts Healthy Volunteers
N/A
Sampling Method
Non-Probability Sample
Study Population
patients having had a prosthetic joint infection and having had a postoperative empirical antibiotherapy with combination of vancomycine and piperacillin-tazobactam or vancomycine and cefepime manage at the croix rousse hospital
Description
Inclusion Criteria:
- patients having had a prosthetic joint infection and having had a postoperative empirical antibiotherapy with combination of vancomycine and piperacillin-tazobactam or vancomycine and cefepime
Exclusion Criteria:
- none
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
empirical antibotherapy currently used
patients having had a vancomycin and piperacillin-tazobactam combination as empirical antibiotherapy
|
comparison of the outcome in the 2 groups having had 2 different empirical antibiotherapies
|
another empirical antibotherapy
patients having had a vancomycin and cefepime combination as empirical antibiotherapy
|
comparison of the outcome in the 2 groups having had 2 different empirical antibiotherapies
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rate of Treatment Failure
Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
|
Treatment failure is defined by local clinical and/or microbiological relapse; and/or need for additional surgery; death of septic origin
|
Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
rate of bacteria responsible for infection
Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
|
bacterial epidemiology
|
Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
|
rate of adverse events
Time Frame: Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
|
Description of adverses events leading to stop the empirical treatment
|
Outcome is measured at the end of follow-up (usually between 12 and 24 months after antibiotic therapy disruption
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Florent Valour, Md,PhD, HCL
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
December 1, 2018
Primary Completion (Actual)
March 1, 2019
Study Completion (Actual)
June 1, 2019
Study Registration Dates
First Submitted
February 20, 2019
First Submitted That Met QC Criteria
February 20, 2019
First Posted (Actual)
February 22, 2019
Study Record Updates
Last Update Posted (Actual)
September 22, 2023
Last Update Submitted That Met QC Criteria
September 21, 2023
Last Verified
September 1, 2023
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 18-326
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
UNDECIDED
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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