- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04015830
Exploring Racial Disparities in Sleep Health and Neurocognitive Function
July 9, 2019 updated by: Shameka L. Cody, University of Alabama, Tuscaloosa
Exploring Racial Disparities in Sleep Health and Neurocognitive Function in Older Adults With HIV
Despite longer life expectancies due to combination antiretroviral therapy (cART), the prevalence of HIV-associated neurocognitive disorders (HAND) persists thus affecting 52% of the HIV population.
Poor sleep quality is commonly reported in older adults and has been related to neurocognitive impairments.
This is concerning given studies have shown that up to 75% of adults with HIV experience poor sleep, and by 2020, 70% of adults with HIV will be age 50 and older.
It is important to examine sleep quality as it relates to neurocognitive function and HAND in older adults with HIV given its negative impact on cART adherence.
Compared to Whites with HIV, African Americans (AA) are disproportionately affected by HIV and are more likely to experience poor sleep quality.
This primary goal of this 1-year cross-sectional study is to examine racial differences in sleep quality and neurocognitive function among 60 African Americans and Whites with HIV (age 50+).
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Detailed Description
This study is designed with two aims: Aim 1a: To explore differences in sleep health between older HIV+ AA and Whites.
1b: To explore differences in domain-specific neurocognitive impairments between older HIV+ AA and Whites.
Aim 2a: To explore the relationship between sleep health and neurocognitive function.
2b: To explore the relationship between sleep health and cART adherence.
2c: To explore mediation effects of cART adherence between sleep health and neurocognitive function.
This is the first study to explore racial disparities in sleep health and neurocognitive function, using EEG/ERP metrics, among older HIV+ adults.
There are two phases in this study: Phase I which consists of neurocognitive testing and sleep assessments with actigraphy, and Phase II which consist of a 20-30 min EEG.
Measurements of electrical brain activity will be captured while participants engage in an Attention Network Test which measures executive function, attention, and speed of processing.
Study Type
Interventional
Enrollment (Anticipated)
60
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Shameka L Cody, PhD
- Phone Number: 2053483374
- Email: slcody@ua.edu
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
50 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- HIV+
- Identify as AA or White
- 50 years old or older
- Speak English
Exclusion Criteria:
- Alzheimer's disease or dementia
- Severe neurocognitive impairment (>7 errors on the Short Portable Mental Status Questionnaire)
- Deaf or blind
- Currently undergoing radiation/chemotherapy
- Brain trauma with loss of consciousness greater than 30 minutes
- A learning disability
- Significant neuromedical comorbidities (e.g., schizophrenia)
- Currently taking Efavirenz
- Moderate to severe sleep apnea
- Restless leg syndrome
- Narcolepsy
- Left handedness
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: BASIC_SCIENCE
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Older Adults with HIV (N = 60)
African Americans and Whites age 50 and older
|
This is an exploratory study of EEG/ERP measures in older African American and Whites with HIV
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Subjective Sleep Health
Time Frame: Day 1
|
Pittsburgh Sleep Quality Index (PSQI), the components are summed to create a global score between 0 and 21, with a global score of 5 or greater indicating poor sleep quality
|
Day 1
|
Sleep Onset and Wake Time
Time Frame: 7 days
|
A sleep diary will be used to evaluate sleep onset and wake time.
Participant will be asked to document the time they fall asleep and the time they wake up
|
7 days
|
Insomnia Severity
Time Frame: Day 1
|
Insomnia Severity Index is a measure of insomnia.
Total scores ranging from 0-28 with higher scores indicating more severe clinical insomnia
|
Day 1
|
Speed of Processing
Time Frame: Day 1
|
Trails Making A Test is a measure of speed of processing (timed task) with greater time to complete task (in minutes) indicating poorer speed of processing
|
Day 1
|
Executive Function
Time Frame: Day 1
|
Trails Making Test B is a measure of executive function (timed task) with greater time to complete task (in minutes) indicating poorer executive function
|
Day 1
|
Attention
Time Frame: Day 1
|
Paced Auditory Serial Addition Task is a measure of attention (50 items) with greater number of items correct indicating good attention span
|
Day 1
|
Spatial Visualization
Time Frame: Day 1
|
Wechsler Adult Intelligence Scale (WAIS III) is a measure of spatial visualization.
Scores on items are summed for a maximum score of 21 with greater scores indicating better spatial visualization
|
Day 1
|
Verbal Learning and Memory
Time Frame: Day 1
|
Hopkins Verbal Learning Test-Revised (Recall and Delayed) is a measure of verbal learning and memory.
Three learning trials are summed to calculate a total recall score (maximum score is 36) with greater scores indicating better verbal learning and memory.
The delayed recall score is the number of items correct (maximum score is 12) after 25-minutes with greater scores indicating better delayed recall.
|
Day 1
|
Brief Visuospatial Memory Test (BVMT) (Recall and Delayed)
Time Frame: Day 1
|
Measure of visuospatial memory, three learning trials are summed to calculate a total recall score (maximum score is 36) with greater scores indicating better visuospatial memory.
The delayed recall score is the number of items correct (maximum score is 12) after 25-minutes with greater scores indicating better delayed visuospatial memory.
|
Day 1
|
Sleep Onset
Time Frame: Day 1
|
Actigraphy will measure sleep onset which is the time (in minutes) it takes to fall asleep with longer times indicating worse sleep onset.
Time (in minutes) is averaged over 7 days.
|
Day 1
|
Total Sleep Time
Time Frame: Day 1
|
Actigraphy will measure total sleep time which is the number of sleep hours with lesser hours indicating worse sleep deficiency.
Time (in hours) is averaged over 7 days.
|
Day 1
|
Wake After Sleep Onset
Time Frame: Day 1
|
Actigraphy will measure wake after sleep onset which is the number of awakenings after sleep onset with greater number of episodes indicating sleep fragmentation/poorer sleep.
|
Day 1
|
Sleep Efficiency
Time Frame: Day 1
|
Actigraphy will measure sleep efficiency which is the percentage of time spent sleep while in bed.
It is calculated by dividing the total sleep time (in minutes) by the total amount of time in bed (in minutes) with 85-95% indicating good sleep efficiency.
|
Day 1
|
Reaction Time
Time Frame: Day 1
|
The Attention Network Test is a computerized measure of reaction times (in milliseconds) to presented stimuli over several trials.
Mean reaction time is calculated by averaging the reaction times over 7 trials, with longer mean reaction times indicating poorer attention.
|
Day 1
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Medication Adherence
Time Frame: Day 1
|
Simplified Medication Adherence Questionnaire is a measure of antiretroviral adherence, a participant is non-adherent if he/she has missed more than two doses within the last week or has not taken any medication for two complete days within the last three months
|
Day 1
|
Instrumental Activities of Daily Living
Time Frame: Day 1
|
Brody and Lawton Instrumental Activities of Daily Living is a measure of instrumental activities of daily living, scores from 8 categories (ability to use telephone, shopping, food preparation, housekeeping, laundry, mode of transportation, responsibility of own medications, and ability to handle finances) are summed for a total score ranging from 0 (low function, dependent) to 8 (high function, independent) for women and 0 (low function, dependent) to 5 (high function, independent) for men
|
Day 1
|
Everyday Problem Solving Skills
Time Frame: Day 1
|
Everyday Problems Test is a 42 iteme measure of everyday function in several categories (consumerism, meal preparation, medication use, financial management, transportation, phone usage, and housekeeping).
Categorical scores are summed to calculate a total score ranging from 0 - 42 with greater scores indicating better everyday problems solving skills.
|
Day 1
|
Depression
Time Frame: Day 1
|
Patient Health Questionnaire - 9 is a measure of depressive symptoms, 9-items are summed for a total score ranging from 0-27 with higher scores indicating more severe depressive symptoms
|
Day 1
|
Health Related Quality of Life
Time Frame: Day 1
|
Medical Outcomes Study - HIV is a 35-item questionnaire with subscales (health perceptions, pain, physical functioning, role functioning, social functioning, cognitive functioning, mental health, energy, health distress, quality of life, and health transition.
Subscales are summed for a total score between 0 and 100 with higher scores indicating better health or well-being.
|
Day 1
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Shameka L Cody, PhD, The University of Alabama
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ANTICIPATED)
August 1, 2019
Primary Completion (ANTICIPATED)
June 30, 2020
Study Completion (ANTICIPATED)
June 30, 2020
Study Registration Dates
First Submitted
April 29, 2019
First Submitted That Met QC Criteria
July 9, 2019
First Posted (ACTUAL)
July 11, 2019
Study Record Updates
Last Update Posted (ACTUAL)
July 11, 2019
Last Update Submitted That Met QC Criteria
July 9, 2019
Last Verified
July 1, 2019
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Mental Disorders
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- RNA Virus Infections
- Virus Diseases
- Infections
- Blood-Borne Infections
- Communicable Diseases
- Sexually Transmitted Diseases, Viral
- Sexually Transmitted Diseases
- Lentivirus Infections
- Retroviridae Infections
- Immunologic Deficiency Syndromes
- Immune System Diseases
- Neurocognitive Disorders
- Dementia
- HIV Infections
- AIDS Dementia Complex
Other Study ID Numbers
- UATuscaloosa
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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