- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04021875
The Effects of Autologous SLET
July 14, 2019 updated by: National Taiwan University Hospital
The Effects of Autologous Simple Limbal Epithelial Transplantation.
This study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency.
The change of visual acuity, quality of life and so on will be monitored before and after surgery.
Study Overview
Status
Recruiting
Conditions
Detailed Description
Human corneal epithelial cells are stratified squamous cells that cover the corneal surface.
These cells are regenerated from cells known as limbal stem cells (LSCs) that grow continuously and proliferate from the limbus.
Failure or damage at the limbal zone can occur from hereditary or acquired causes such as ocular burns, trauma, or diseases such as Stevens- Johnson syndrome, leading to limbal stem cell deficiency (LSCD).
The treatment of LSCD includes transplantation of healthy limbal tissue or cultured limbal epithelial cells.
In the last two decades, cultivated limbal epithelial transplantation (CLET) has been a widely used technique.
In 2012, Sangwan and coworkers proposed a novel technique that they named simple limbal epithelial transplantation (SLET) for the treatment of unilateral LSCD1.
SLET could have benefits for those centers that do not have the ability to perform cultivated limbal epithelial transplantation (CLET) preparation and could be especially useful for those countries that cannot afford a GMP center.
Therefore, SLET is quickly gaining popularity in countries like India.
As it is a relatively new technique, its long-term clinical effectiveness (similar to what is observed in CLET) must be noted before determining its actual benefits.Our study aims to prospectively evaluate the therapeutic effects of autologous simple limbal epithelial transplantation for patients with limbal stem cell deficiency.
The change of visual acuity, quality of life and so on will be monitored before and after surgery.
In this study, the effects of autologous simple limbal epithelial transplantation will be investigated.
Study Type
Observational
Enrollment (Anticipated)
30
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Taiwan, Republic Of China
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Taipei, Taiwan, Republic Of China, Taiwan, 10002
- Recruiting
- National Taiwan University Hospital
-
Contact:
- Wei-Li Chen, PhD
- Phone Number: Visual acuity +886223123456
- Email: cwlntuh@gmail.com
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
10 years to 90 years (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Patients with limbal stem cell deficiency
Description
Inclusion Criteria:
- Age 10-90 years old
- The lesion eye has at least grade 2 limbal stem cell deficiency
- The lesion eye has limbal stem cell deficiency causing recurrent corneal erosion and neovascularization ingrowth
- The symptoms last for at least 6 months and do not improve with medication
Exclusion Criteria:
- Symptoms improve spontaneously or under medication
- Someone who can not be examined regularly after the operation
- Someone with poor prognosis
- Severe lagophthalmos or trichiasis that has not been corrected
- Ocular infection
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Numbers of patients with clinical success
Time Frame: 6 months
|
Clinical success was defined as a completely epithelized, avascular, stable corneal surface.
Failure was defined as a recurrence of fibrovascular pannus encroaching on the central cornea, frequent epithelial breakdown or persistent epithelial defects.
Kaplan-Meier survival curves were constructed and survival probability calculated using the SPSS software for statistical computing.
Focal recurrences of pannus not progressing to the central cornea were not considered as failures and were evaluated separately.
|
6 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Visual acuity change
Time Frame: 6 months
|
Secondary outcome measures included change from baseline visual acuity at 6 months
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Sangwan VS, Basu S, MacNeil S, Balasubramanian D. Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency. Br J Ophthalmol. 2012 Jul;96(7):931-4. doi: 10.1136/bjophthalmol-2011-301164. Epub 2012 Feb 10.
- Vazirani J, Ali MH, Sharma N, Gupta N, Mittal V, Atallah M, Amescua G, Chowdhury T, Abdala-Figuerola A, Ramirez-Miranda A, Navas A, Graue-Hernandez EO, Chodosh J. Autologous simple limbal epithelial transplantation for unilateral limbal stem cell deficiency: multicentre results. Br J Ophthalmol. 2016 Oct;100(10):1416-20. doi: 10.1136/bjophthalmol-2015-307348. Epub 2016 Jan 27.
- Borroni D, Wowra B, Romano V, Boyadzhieva M, Ponzin D, Ferrari S, Ahmad S, Parekh M. Simple limbal epithelial transplantation: a review on current approach and future directions. Surv Ophthalmol. 2018 Nov-Dec;63(6):869-874. doi: 10.1016/j.survophthal.2018.05.003. Epub 2018 May 22.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
July 5, 2019
Primary Completion (Anticipated)
July 1, 2020
Study Completion (Anticipated)
July 1, 2025
Study Registration Dates
First Submitted
July 3, 2019
First Submitted That Met QC Criteria
July 14, 2019
First Posted (Actual)
July 16, 2019
Study Record Updates
Last Update Posted (Actual)
July 16, 2019
Last Update Submitted That Met QC Criteria
July 14, 2019
Last Verified
June 1, 2019
More Information
Terms related to this study
Other Study ID Numbers
- 201904117RINB
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
IPD Plan Description
No IPD sharing
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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