- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04053400
Evaluating Ketamine and Psychological Sequelae (ERASE)
ERASE: Evaluation of the Relationship of the Anesthetic Agent Ketamine and Psychological Sequelae
Study Overview
Status
Intervention / Treatment
Detailed Description
The purpose of this study is to examine the relationship between the use of intravenous infusion of sub-anesthetic dosages of ketamine given for pain to combat casualties and emerging symptoms of Post-Traumatic Stress Disorder (PTSD), depression, anxiety, sleep disruption, and risk of alcohol abuse as identified with behavioral health screening tools.
This is retrospective case-control study. The data will be analyzed to examine the relationship between exposure to ketamine used as an analgesic agent in combat related trauma care and the expression of psychiatric symptoms measured in the follow-up on the Post Deployment Health Assessment Tool (PDHAT), in use 2003-2007 and the Post Deployment Behavioral Health Assessment (PDBHA), in use 2007 to current date. Coded behavioral health assessment data will be extracted from the research data bank (Protocol IRBnet # 360023, titled "Use of Post Deployment Behavioral Health Assessment Data from Aerovaced Military Admitted to Walter Reed from the Theater of Operations in Iraq and Afghanistan to Establish a Research Data Bank"). This protocol, approved in 2012, has retrospective and prospective components and was designed for studies of this nature. The second objective of this study is to explore demographic and clinical risk factors associated with psychological factors.
Service members who completed the PDHAT or the PDBHA after being AEROVAC-ED from theater for medical care will be grouped according to whether or not they received ketamine for pain before their follow-up assessments. The comparison group for this study will be selected from among those not exposed to ketamine by matching two service members to each in the ketamine group using Injury Severity Scores (ISSs) and Abbreviated Injury Scores (AISs). These scores, originally collected by the US Army Institute of Surgical Research (USAISR) and stored in the Department of Defense Trauma Registry (DoDTR), are an IRB approved addition to the DoP research data bank. WRNMMC and the USAISR have a Memorandum of Understanding allowing use of the scores for research purposes.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Maryland
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Bethesda, Maryland, United States, 20889
- Walter Reed National Military Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
Group I. Ketamine Group
- Active duty military service member injured in theater and treated at WRAMC or at WRNMMC
- 18 years of age or older
- Completed the PBBHA or PDHAT initial and follow up assessment post aerovac from theater
- Received ketamine infusion to treat pain after aero-evacuation for inpatient medical care between Sep 2005 and June 2014
- Received ketamine before completion of the PDHAT or PDBHA follow-up assessment
- ISS scores are available for each individual
Group II. Non-Ketamine Comparison Group
- Active duty military service member injured in theater and treated at WRAMC or at WRNMMC
- 18 years of age or older
- Completed the PBBHA or PDHAT initial and follow up assessment post aerovac from theater
- Did not receive ketamine treatment for pain after aero-evacuation for inpatient medical care before follow-up
- ISS are available for each individual
- Patient will have ISS scores similar to a Ketamine Group patient and a similar timing of injury to the same Ketamine Group patient.
Exclusion Criteria:
- Not treated by WRNMMC/WRAMC hospital staff between Sep 2005 and June 2014
- Not active duty, activated National Guard, or activated Reserve service members
- Younger than 18 years of age
- Did not complete the PDBHA or PDHAT initial and follow-up assessments
- ISS scores are not available
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Ketamine Group
Active duty military service member injured in theater, AEROVAC-ED out, and received ketamine.
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Non-Ketamine Comparison Group
Active duty military service member injured in theater, AEROVAC-ED out, and did NOT receive ketamine treatment for pain.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Post Deployment Health Assessment Tool/Post Deployment Behavioral Health Assessment - Coded behavioral health assessment data will be extracted from the research data bank using Injury Severity Scores (ISSs)
Time Frame: 30 days after return home or processing station
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Review wounded warrior's health including mental health post deployment.
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30 days after return home or processing station
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Post Deployment Health Assessment Tool/Post Deployment Behavioral Health Assessment - Coded behavioral health assessment data will be extracted from the research data bank using Abbreviated Injury Scores (AISs)
Time Frame: 30 days after return home or processing station
|
Review wounded warrior's health including mental health post deployment.
|
30 days after return home or processing station
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Anesthetics, Dissociative
- Anesthetics, Intravenous
- Anesthetics, General
- Anesthetics
- Excitatory Amino Acid Antagonists
- Excitatory Amino Acid Agents
- Ketamine
Other Study ID Numbers
- 380486
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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