- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04078048
Role of Antioxidants (Vitamin C and E) in the Management of Schizophrenia
September 13, 2019 updated by: Saima Zahid, University of Health Sciences Lahore
Role of Selected Antioxidants (Vitamin C and E) in the Management of Schizophrenia
Background: Antioxidants are substances that are considered as a defensive material which protects cells from destruction.
It is evident that use of food stuff rich in antioxidant will fortify one's ability to encounter with physical & mental disorders.
Since, among several potential elucidations, oxidative stress is more likely deliberated as one of the causative factors which give rise to cognitive and functional impairment.
This deterioration further result in intricacy in ones thought process as progressive brain changes crop-up schizophrenic unfold.
Therefore, this study was conducted with objectives to explore the role of selected antioxidants (vitamin C & E) and to compare the role of both vitamins as an add-on management of schizophrenia .Materials & Methods: One hundred and five patients were selected from department of psychiatry King Edward Medical University Lahore, and assigned into 3 groups by simple random lottery method.
For eight weeks, Vitamin C group intervened with 500mg vitamin C tablet once a day, vitamin E group with 600IU vitamin E twice daily and placebo group was given 500 mg paraffin oil capsule daily.
PANSS scale was used to assess the symptoms of schizophrenia.
Demographic information was collected by structured questionnaire.
Dietary habits were assessed by food frequency questionnaire.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Background: Antioxidants such as Vitamin C and E are substances that are considered as a defensive material which protects cells from destruction.
It is evident that use of food stuff rich in antioxidant will fortify one's ability to encounter with physical & mental disorders.
Since, among several potential elucidations, oxidation stress is more likely deliberated as one of the causative factors which give rise to cognitive and functional impairment.
Therefore, this study was conducted with objectives to explore the role of selected antioxidants (vitamin C & E) and to compare the role of both vitamins as an add-on management of schizophrenia .Materials & Methods: One hundred and five patients were selected from department of psychiatry King Edward Medical University Lahore, and assigned into 3 groups by simple random lottery method.
For the period of two months, Vitamin C group intervened with 500 mg vitamin C tablet once a day, vitamin E group with 600 I U vitamin E twice daily and placebo group was given 500 mg paraffin oil capsule daily.
PANSS (Positive and Negative Symptoms Scale) was used to assess the symptoms of schizophrenia.
Demographic information was collected by structured questionnaire.
Dietary habits were assessed by (FFQ) food frequency questionnaire.
Study Type
Interventional
Enrollment (Actual)
105
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Punjab
-
Lahore, Punjab, Pakistan, 54000
- Saima Kouser
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 48 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
INCLUSION CRITERIA:
- All diagnosed schizophrenic patients 20-50 years of age
- visited department of psychiatry & behavioral sciences King Edward medical university Lahore.
EXCLUSION CRITERIA:
- Patients diagnosed with axis i and axis ii disorders
- having any other pathological condition like hypertension, hyperlipidemia, and cardiac disorders.
Exclusion Criteria:
-
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Factorial Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Vitamin C Group
Tablet Vitamin C 500 mg Once a day
|
For eight weeks, Vitamin C group was intervened with tablet vitamin c 500 mg once a day ,vitamin E group was intervened with Tablet vitamin E 600 I U twice a day.
Other Names:
|
Experimental: Vitamin E Group
Tablet Vitamin E 600 I U Twice daily
|
For eight weeks, Vitamin C group was intervened with tablet vitamin c 500 mg once a day ,vitamin E group was intervened with Tablet vitamin E 600 I U twice a day.
Other Names:
|
Placebo Comparator: Placebo Group
Capsule Paraffin oil 500 mg Once a day
|
For eight weeks, Vitamin C group was intervened with tablet vitamin c 500 mg once a day ,vitamin E group was intervened with Tablet vitamin E 600 I U twice a day.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Positive and Negative Syndrome Scale
Time Frame: 45-50 minutes
|
The Positive and Negative Syndrome Scale (PANSS) is a medical scale used for measuring symptom severity of patients with schizophrenia.The PANSS yields a total average symptom score, based on 30 items rated from one to seven (range=30-210).
Higher scores indicate more severe symptoms.
|
45-50 minutes
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 27, 2017
Primary Completion (Actual)
August 11, 2017
Study Completion (Actual)
November 15, 2017
Study Registration Dates
First Submitted
September 1, 2019
First Submitted That Met QC Criteria
September 3, 2019
First Posted (Actual)
September 4, 2019
Study Record Updates
Last Update Posted (Actual)
September 17, 2019
Last Update Submitted That Met QC Criteria
September 13, 2019
Last Verified
September 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- UHS
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
IPD Plan Description
clinical trails registration
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
product manufactured in and exported from the U.S.
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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