Anlotinib In Combination With RFA And TACE in Patients With Middle-advanced HCC

Anlotinib Hydrochloride In Combination With Radiofrequency Ablation And Transcatheter Arterial Chemoembolization in Patients With Middle-advanced Hepatocellular Carcinoma, Open, Single Arm, Exploratory Clinical Trial

A single-arm, open-label clinical trial, focus on the safety and efficacy of anlotinib hydrochloride in combination with radiofrequency ablation (RFA) and transcatheter arterial chemoembolization(TACE) in patients with middle-advanced hepatocellular carcinoma(HCC)

Study Overview

• Status: Recruiting
• Conditions: Hepatocellular Carcinoma
• Intervention / Treatment: Drug: Anlotinib; Device: TACE+RFA

• Study Type: Interventional
• Enrollment (Anticipated): 48
• Phase: Phase 2

Contacts and Locations

• Study Contact: Name: XiaoYan Ding, M.D; Phone Number: +86 13811560276; Email: dingxiaoyan198111@163.com

Study Locations

• China
  • Dalian, China
    • Not yet recruiting
    • The first affiliated hospital of Dalian Medical University
  • Shenyang, China
    • Not yet recruiting
    • Shengjing Hospital of China Medical University
    • Contact: Zaiming Lu
  • Beijing
    • Beijing, Beijing, China, 100011
      • Recruiting
      • Beijing Ditan Hospital, Capital Medical University
      • Contact: Xiaoyan Ding, M.D.; Phone Number: +86 13811560276; Email: dingxiaoyan198111@163.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients participate in the study voluntarily and sign informed consent with good compliance.
• Histological or cytological confirmation of unrespectable middle-advanced hepatocellular carcinoma, Barcelona Clinic Liver Cancer stage Category C or B , liver function child-Pugh class A or B (≤7 points).
• At least one measurable lesion, with diameter ≥ 10mm measured by spiral MRI/CT scan per mRECIST; have not received local therapies including but not limited to TACE, RFA, radiotherapy and cryosurgery.-Eastern Cooperative Oncology Group Performance Status 0 or 1.
• Life expectancy of at least 3 months.
• Main organs function is normal. (normal main organs function as defined below: Hemoglobin (Hb) ≥ 90 g/L, Neutrophils (ANC) ≥ 1.5×109/L, leucocyte (WBC) ≥ 3.0×109/L, Platelet count (PLT) ≥ 70×109/L, Total bilirubin (TBIL) ≤ 1.5 × normal upper limit (ULN), Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ≤ 2.5 ×ULN, Serum creatinine (Cr) ≤ 1.5× ULN or Creatinine Clearance rate(CCr) ≥60ml/min,Doppler ultrasound evaluation: left ventricular ejection fraction (LVEF) > 50%)
• The woman patients of childbearing age who must agree to take contraceptive methods (e.g. intrauterine device, contraceptive pill or condom) during the research and within another 3 months after it; who are not in the lactation period and examined as negative in blood serum test or urine pregnancy test within 7 days before the research; The man patients who must agree to take contraceptive methods during the research and within another 8 weeks after it.
• Patients have disease that is not amenable to potentially curative transplantation or ablation
• Patients who have characterization for targeted therapy treatment, but under poor economic conditions and cannot afford angiogenesis inhibitors recommended by current guidelines, including Lenvatinib, sorafenib, Cabozantinib, Ramolumab, regorafenib, etc.

Exclusion Criteria:

• History of other malignancy within 5 years or for now (except for non-melanoma skin cancer, cervix in situ carcinoma, superficial Bladder neoplasms).
• Subject has obstacle in the function of major organs such as heart, lung, liver and kidney
• Patients who plan liver transplantation.
• Patients who had previously received treatment with target inhibitors or other immunotherapy against or chemotherapy
• Patients who had previously received treatment with TACE or or other local therapy or radiotherapy or Chinese medicine treatment within 4 weeks.
• Liver function status Child-Pugh Class C, with malignant ascites.
• Participated in other anti-tumor clinical trials within 4 weeks.
• Symptoms that affect oral medication and cannot be controlled through proper treatment (such as inability to swallow, chronic diarrhoea and intestinal obstruction, etc.).
• Any of the following coagulation functions are abnormal, including: Prothrombin time (PT)>ULN+4s, Activated partial thromboplastin time (APTT) >1.5ULN s, nternational normalized ratio (INR)>1.5
• Patients who underwent major surgery within 4 weeks.
• Patients who have got non remissive toxic reactions derived from any treatment, which is over level 1 in CTC AE (4.0).
• Patients with any severe and/or unable to control diseases，including： Patients with unsatisfactory blood pressure control using antihypertensive drugs (systolic blood pressure ≥150 mmHg or diastolic blood pressure ≥100) mmHg); Patients with Grade 1 or higher myocardial ischemia, myocardial infarction or malignant arrhythmias(including QTc≥480ms) and patients with Grade 2 or higher congestive heart failure (NYHA Classification); Patients with active or unable to control serious infections, which is over level 2 in CTC AE (4.0); Patients with poorly controlled diabetes (fasting blood glucose(FBG)>10mmol/L); Patients with kidney failure who require hemodialysis or peritoneal dialysis; Patients with a history of immunodeficiency, including a positive HIV test or other acquired, congenital immunodeficiency disease, or a history of organ transplantation; Urine routine indicates that urine protein ≥ ++, and confirmed 24-hour urine protein quantitation > 1.0 g.
• Patients whose tumors had invaded important blood vessels by imaging or who, as determined by the researchers, were likely to invade important blood vessels during follow-up trial, resulting in fatal bleeding.
• Patients with arterial or venous thromboembolic events occurred within 6 months, such as cerebrovascular accident (including transient ischemic attack), deep vein thrombosis and pulmonary embolism.
• Regardless of the severity, patients with any physical signs or history of bleeding, patients with bleeding or bleeding events greater than or equal to CTCAE 3 within four weeks prior to the first administration, or patients with unhealed wounds, fractures, ulcers.
• Patients with Brain metastases.
• Patients with cancer thrombus involving whole the main portal vein.
• Female patients who are pregnant or breastfeeding.
• Patients with drug abuse history and unable to get rid of or patients with mental disorders.
• Patients with concomitant diseases which could seriously endanger their own safety or could affect completion of the study according to investigators' judgment.
• History of gastrointestinal bleeding due to severe gastroesophageal varices within 4 weeks.
• Severe active or uncontrolled infections.
• Patients who had serious adverse effect to Anlotinib.
• Patients who had serious adverse effect to iodinated contrast agent.
• Liver cirrhosis, hepatic decompensation, active hepatitis or chronic hepatitis which requires anti-viral treatment. Hepatitis C virus (HCV) antibody test shows positive and titer test shows amount of HCV exceeds upper limit of normal (ULN) after treatment

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Anlotinib+ TACE+ RFA	Drug: Anlotinib; 12mg, continuous oral 2 weeks stop for 1 week, 21 days for a treatment cycle.; Device: TACE+RFA; TACE first, followed by RFA within day7（+/-3days）

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time To Progression(TTP)	Time To Progression is defined as the time from first day of TACE treatment until the first date of either objective disease progression	each 42 days up to progressive disease (PD) (up to 24 months)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Objective Response Rate (ORR)	Objective response rate is defined as the percentage of subjects whose best response was complete response (CR) or partial response (PR) according to the Modified Response Evaluation Criteria in Solid Tumors Version (mRECIST).	each 42 days up to intolerance the toxicity or PD (up to 24 months)
Disease Control Rate (DCR)	Disease control rate is defined as the percentage of subjects whose best response was CR, PR or stable disease (SD) according to the mRECIST.	each 42 days up to intolerance the toxicity or PD (up to 24 months)
Duration of Response (DOR)	Duration of Response is defined as the percentage of subjects whose best response was CR, PR or stable disease (SD) according to the mRECIST or death due to any cause, whichever occurs first.	Time Frame: each 42 days up to intolerance the PD or death (up to 24 months)
Incidence of Treatment-Emergent Adverse Events	Safety and Tolerability	Until 30 day safety follow-up visit

Collaborators and Investigators

• Sponsor: Jinglong Chen

Study record dates

Study Major Dates

• Study Start (Actual): November 28, 2019
• Primary Completion (Anticipated): September 1, 2022
• Study Completion (Anticipated): March 30, 2023

Study Registration Dates

• First Submitted: November 6, 2019
• First Submitted That Met QC Criteria: November 6, 2019
• First Posted (Actual): November 8, 2019

Study Record Updates

• Last Update Posted (Actual): December 3, 2019
• Last Update Submitted That Met QC Criteria: November 30, 2019
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Keywords: HCC; anlotinib; TACE; RFA
• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms by Histologic Type; Neoplasms; Neoplasms by Site; Adenocarcinoma; Neoplasms, Glandular and Epithelial; Digestive System Neoplasms; Liver Diseases; Liver Neoplasms; Carcinoma; Carcinoma, Hepatocellular
• Other Study ID Numbers: 320.6750.19089-49

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No