Anthropometric And Body Composition Measurements Related To Osteoporosis In Geriatric Population

The patients who consulted to the geriatric outpatient clinic between 2018 and 2019 were included in the study. The inclusion criterions were being at or over the age of 65 and diagnosed with osteoporosis according to WHO criteria. Exclusion criteria include vertebral fracture due to known accidental traumas, history of drug therapy in the past year (biphosphonate, estrogen replacement therapy, glucocorticoids ), history of co-morbidities as malignancy, radiotherapy or chemotherapy, renal failure, hyperthyroidism, primer hyperparathyroidism, rheumatic disease or adrenal diseases.

Initially, a demographic form including age, sex, comorbidities, weight, height was filled by the participants. Body mass index (BMI, ratio of height and weight, expressed as kg/m2) calculated. Patients waist and hip circumference was measured (cm).

Fat percentage and skeletal muscle mass (SMM) was calculated by using bioimpedance analysis (BIA) (Tanita TBF 300; Tanita Corp., Tokyo, Japan). Skeletal muscle index (SMI) was calculated from BIA-based skeletal muscle mass with a formula as SMM/height [m2] [8]. ABSI is measured as waist circumference (m) / (BMI(kg)2/3x Height(m)5/6) [4].

Osteoporosis was evaluated by using dual energy x-ray absorptiometry (DXA). According to the T-scores calculated from femur neck (FN) and lumbar spine (LS), subjects divided into 3 groups as following: a) normal: T-score is greater than -1 SD, b) osteopenia: T-score is between -1 and -2.5 SD, c) osteoporosis: T-score is lower than -2.5 SD.

Physical activity levels of patients were evaluated with The Rapid Assessment of Physical Activity (RAPA) aerobic assessment [9]. Patients divided into 5 groups as following: 1 = sedentary, 2 = underactive, 3 = regular underactive (light activities), 4 = regular underactive, and 5 = regular active).

The study protocol was approved by the ethics committee (2018/0478) and all participants gave written informed consent.

Study Overview

• Status: Completed
• Conditions: Obesity, Visceral; Osteoporosis Senile
• Intervention / Treatment: Diagnostic test: Body mass index; Diagnostic test: waist circumference; Diagnostic test: hip circumference; Diagnostic test: height; Diagnostic test: Fat percentage; Diagnostic test: Skeletal muscle index; Diagnostic test: A body shape index (ABSI); Diagnostic test: Dual energy x ray absorptiometry (DXA); Diagnostic test: The Rapid Assessment of Physical Activity (RAPA) aerobic assessment

• Study Type: Interventional
• Enrollment (Actual): 571
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey, 34732
    • Istanbul Medeniyet University Faculty of Medicine, Physical Therapy and Rehabilitation Department

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• being at or over the age of 65
• diagnosed with osteoporosis according to WHO criteria

Exclusion Criteria:

• vertebral fracture due to known accidental traumas
• history of drug therapy in the past year (biphosphonate, estrogen replacement therapy, glucocorticoids )
• history of co-morbidities as malignancy, radiotherapy or chemotherapy, renal failure, hyperthyroidism, primer hyperparathyroidism, rheumatic disease or adrenal diseases

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Diagnostic
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Geriatric osteoporotic patients; We measured different anthropometric and body composition measurements as body weight, BMI, percentage body fat, skeletal muscle index (SMI), ABSI, waist (WC) and hip circumference (HC) in geriatric population to investigate the relation to osteoporosis.

Diagnostic test: Body mass index; Body mass index is calculated as a ratio of height and weight, expressed as kg/m2; Diagnostic test: waist circumference; waist circumference is measured as cm; Diagnostic test: hip circumference; hip circumference is measured as cm; Diagnostic test: height; height is measured as cm; Diagnostic test: Fat percentage; Fat percentage and skeletal muscle mass (SMM) was calculated by using bioimpedance analysis (BIA) (Tanita TBF 300; Tanita Corp., Tokyo, Japan).; Diagnostic test: Skeletal muscle index; Skeletal muscle index (SMI) was calculated from BIA-based skeletal muscle mass with a formula as SMM/height [m2].; Diagnostic test: A body shape index (ABSI); ABSI is measured as waist circumference (m) / (BMI(kg)2/3x Height(m)5/6); Diagnostic test: Dual energy x ray absorptiometry (DXA); Osteoporosis is diagnosed with DXA scores. According to the T-scores calculated from femur neck (FN) and lumbar spine (LS), subjects divided into 3 groups as following: a) normal: T-score is greater than -1 SD (standard deviation), b) osteopenia: T-score is between -1 and -2.5 SD, c) osteoporosis: T-score is lower than -2.5 SD.; Diagnostic test: The Rapid Assessment of Physical Activity (RAPA) aerobic assessment; Physical activity levels of patients were evaluated with The Rapid Assessment of Physical Activity (RAPA) aerobic assessment. Patients divided into 5 groups as following: 1 = sedentary, 2 = underactive, 3 = regular underactive (light activities), 4 = regular underactive, and 5 = regular active).

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Waist circumference	calculated as cm	2 years
Hip circumference	calculated as cm	2 years
Fat percentage	Fat percentage and skeletal muscle mass (SMM) was calculated by using bioimpedance analysis (BIA) (Tanita TBF 300; Tanita Corp., Tokyo, Japan)	2 years
Skeletal muscle index	Fat percentage and skeletal muscle mass (SMM) was calculated by using bioimpedance analysis (BIA) (Tanita TBF 300; Tanita Corp., Tokyo, Japan). Skeletal muscle index (SMI) was calculated from BIA-based skeletal muscle mass with a formula as SMM/height [m2]	2 years
A body shape index (ABSI)	ABSI is measured as waist circumference (m) / (BMI(kg)2/3x Height(m)5/6)	2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The Rapid Assessment of Physical Activity (RAPA) aerobic assessment	Physical activity levels of patients were evaluated with The Rapid Assessment of Physical Activity (RAPA) aerobic assessment. Patients divided into 5 groups as following: 1 = sedentary, 2 = underactive, 3 = regular underactive (light activities), 4 = regular underactive, and 5 = regular active).	2 years

Collaborators and Investigators

• Sponsor: Istanbul Medeniyet University

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2018
• Primary Completion (Actual): November 1, 2019
• Study Completion (Actual): December 1, 2019

Study Registration Dates

• First Submitted: February 2, 2020
• First Submitted That Met QC Criteria: February 2, 2020
• First Posted (Actual): February 5, 2020

Study Record Updates

• Last Update Posted (Actual): February 5, 2020
• Last Update Submitted That Met QC Criteria: February 2, 2020
• Last Verified: February 1, 2020

More Information

Terms related to this study

• Keywords: osteoporosis; body composition; anthropometrics
• Additional Relevant MeSH Terms: Metabolic Diseases; Overnutrition; Nutrition Disorders; Musculoskeletal Diseases; Bone Diseases; Bone Diseases, Metabolic; Obesity; Osteoporosis; Obesity, Abdominal
• Other Study ID Numbers: IMU OP

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No