- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04294758
Estimation of the Difference Between the Temperature of the Peritoneal Microenvironment and the Central Body Temperature During Laparoscopic Surgery. Prospective Observational Study (TEMP-19)
Study Overview
Status
Conditions
Detailed Description
Prospective unblinded observational study to measure the difference between central and peritoneal temperature during laparoscopic surgery.
CO2 insufflation at the peritoneal level to generate the pneumoperitoneum necessary to perform laparoscopic surgery results in a decrease in peritoneal temperature greater than that generated at the central level (esophageal temperature).
The potential long-term advantages of maintaining normothermia at the peritoneal level during laparoscopic surgery may derive from the reversal of the harmful effects of hypothermia at the level of the peritoneal microenvironment since the regional hypoxia resulting from vasoconstriction and the inhibition of functionality cellular that can favor complications such as bleeding or suture dehiscence.
On the other hand, the immune system can be affected by regional hypothermia in several ways. First, postoperative vasoconstriction restricts metabolic heat to the central regions of the body and accelerates overheating, but can simultaneously reduce tissue perfusion by inhibiting oxidative destruction of neutrophils, which is the first line of defense against bacterial contamination. Second, hypothermia reduces systemic immunity and decreases macrophage motility. Third, hypothermia reduces the recovery capacity necessary for wound contamination.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
-
Valencia, Spain, 46026
- Hospital la Fe
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients older than 18 years.
- Classification of the American Society of Anesthesiologists (ASA I-III).
- Patients who do not have cognitive deficits.
- Prior signed informed consent.
Exclusion Criteria:
- Pregnancy or breastfeeding.
- Refusal of the patient to participate in the study.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Estimation of the difference between peritoneal and central temperature during laparoscopic surgery.
Time Frame: Since the beginning until the end of the surgery
|
Since the beginning until the end of the surgery
|
Assess the difference between peritoneal and central temperature during laparoscopic surgery is modified with the total amount of insufflated gas and / or the duration of surgery.
Time Frame: Since the beginning until the end of the surgery
|
Since the beginning until the end of the surgery
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- FPR-IIS -029-02 Ed. 02
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Laparoscopic Surgery
-
Sefako Makgatho Health Sciences UniversityCompletedLaparoscopic Surgery | Laparoscopic Entry Technique
-
Case Comprehensive Cancer CenterCompletedLaparoscopic Surgery | Vaginal SurgeryUnited States
-
Qianfoshan HospitalNot yet recruiting
-
270SurgicalRecruiting
-
Minimally Invasive Devices, Inc.CompletedLaparoscopic SurgeryUnited States
-
National Institute of Cardiology, Laranjeiras,...Recruiting
-
Stanford UniversityTauTona GroupEnrolling by invitationLaparoscopic SurgeryUnited States
-
Zagazig UniversityCompletedLaparoscopic SurgeryEgypt
-
University of MalayaCompleted
-
Alkermes, Inc.TerminatedLaparoscopic SurgeryUnited States