Enterobius Vermicularis Infestation of the Appendix

Enterobius Vermicularis in Appendectomy Specimens; Clinicopathological Assessment

This study identifies the incidence of appendiceal Enterobius vermicularis (E.v) infestation in all the patients undergoing appendectomy and evaluates the relationship between E.v infestation of the appendix and the acute appendicitis.

Study Overview

• Status: Completed
• Conditions: Parasitic Disease
• Intervention / Treatment: Diagnostic test: Pathology examination

Detailed Description

All the patients undergoing appendectomy surgical procedure for clinical picture of acute appendicitis in 3-years period at our referral hospital were evaluated to pick up the Enterobius vermicularis infestation of the appendix. These cases were evaluated for clinico-laboratory characterization to define the incidence in our country and the relationship between the E.v and initiation of the the inflammatory process to study the possibility of limitation of surgical intervention in acute abdomen conditions.

• Study Type: Observational
• Enrollment (Actual): 1150

Contacts and Locations

Study Locations

• Saudi Arabia
  • Baljurashi, Saudi Arabia
    • Abdulkarim Hasan

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 4 years to 90 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Saudi and non- Saudi patients suffering from acute appendicitis symptoms

Description

Inclusion Criteria:

All routine examined appendectomy specimens

Exclusion Criteria:

Cases with clinical suspicion of tumor Cases attached to the colectomy specimens

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Non-parasitic	Diagnostic test: Pathology examination; Gross and microscopic evaluation
Parasitic	Diagnostic test: Pathology examination; Gross and microscopic evaluation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Association between acute inflammation and Enterobius vermicularis infestation	All the studied Enterobius vermicularis cases will be evaluated microscopically to record the count of acute inflammatory cells per millimeter (mm) and per High Power Field (HPF) using the microscope scale measurement. This count will be compared with the inflamed appendectomy specimens without Enterobius infestation to assess the hypothesis of the association between the Enterobius infestation and the acute appendicitis. Also special stain (congo red) will be implicated in some indicated cases to detect eosinophils, eosinophils will be positively staines (orange color stain means positive) if the stain is faint that means negative and the cell is not eosinophil	3 years
Incidence of Appendiceal Enterobius vermicularis	An incidence of Enterobius infestation will be assessed by studying all the received specimens during a 3 years-period using formatting a master sheet and processing in Excel program	3 years

Collaborators and Investigators

• Sponsor: Al-Azhar University

Study record dates

Study Major Dates

• Study Start (Actual): June 1, 2017
• Primary Completion (Actual): May 31, 2020
• Study Completion (Actual): May 31, 2020

Study Registration Dates

• First Submitted: September 23, 2020
• First Submitted That Met QC Criteria: September 29, 2020
• First Posted (Actual): October 6, 2020

Study Record Updates

• Last Update Posted (Actual): October 6, 2020
• Last Update Submitted That Met QC Criteria: September 29, 2020
• Last Verified: September 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Infections; Parasitic Diseases
• Other Study ID Numbers: 3003

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No