- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04675528
Food Effect on Pharmacokinetics and SafEty of DHP107 (Liporaxel®) FEEL Study (FEEL)
December 15, 2020 updated by: Daehwa Pharmaceutical Co., Ltd.
A Randomized, Open-label, Two-way Crossover Clinical Trial to Evaluate the Food Effect on Pharmacokinetics and Safety of DHP107 (Oral Paclitaxel, Liporaxel®) in Patients With Advanced Solid Tumors (FEEL) / EudraCT no : 2020-004976-16
To evaluate the food effect on pharmacokinetics of DHP107 in patients with advanced solid tumors.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
24
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Erika Hitre, M.D., Ph.D
- Phone Number: +36-1-22-48-763
- Email: hitre@oncol.hu
Study Locations
-
-
-
Budapest, Hungary, 1122
- National Institute of Oncology
-
Contact:
- Erika Hitre, M.D., Ph.D
- Phone Number: +36-1-22-48-763
- Email: hitre@oncol.hu
-
Budapest, Hungary, 1083
- University of Semmelweis, 1st Internal Medicine Clinic, Department of Clinical Pharmacology
-
Contact:
- István TAKÁCS
-
Debrecen, Hungary, 4032
- University of Debrecen-Clinical Center, Internal Medicine Clinic, Department of Clinical Pharmacology
-
Contact:
- Dénes PÁLL
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Subjects who are ≥18 years of age on the date of written informed consent.
Subjects with histologically or cytologically confirmed advanced solid tumors including but not limited to the listed below for which paclitaxel monotherapy has been determined an appropriate therapy at the investigator's discretion.
- Angiosarcoma
- Bladder cancer
- Breast cancer
- Cervical cancer
- Head and neck cancer (if no difficulty with swallowing)
- Kaposi's sarcoma
- Lung cancer
- Ovarian cancer
- Subjects who have a life expectancy of ≥12 weeks.
- Subjects who are able to take oral medication.
- Subjects who have a performance status of ≤ 2 on the Eastern Cooperative Oncology Group (ECOG) scale.
- Subjects who have evaluable disease according to the Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST version 1.1).
- Subjects who have adequate organ functions as indicated by the following laboratory values:
- Subjects who are willing and able to comply with scheduled visits, treatment plans, laboratory tests, and procedures.
- Subjects who have voluntarily agreed to participate by giving written informed consent.
- Women of childbearing potential who have negative pregnancy test results at the screening visit and men with female partners of childbearing potential must agree to use adequate contraception for the duration of the trial and up to 90 days after last dose of study drug
Exclusion Criteria:
- Subjects who have history of severe hypersensitive reaction to the active ingredient or any excipients of DHP107.
- Subjects with following surgical history/medical conditions that may affect drug absorption:
- Subjects who developed cardiovascular disease (unstable angina, myocardial infarction, stroke, and transient ischemic attack) within 24 weeks prior to study entry, which is deemed to be clinically significant by the investigator.
- Subjects with known active hepatitis B or C infection, or hepatobiliary disease, or known history of immunodeficiency virus infection (However, subjects with Gilbert's Syndrome, asymptomatic gallstones, or stable chronic liver disease are, at the discretion of the investigator, eligible for the study. Subjects who are hepatitis B carriers may be eligible if they are on antiviral therapy 2 weeks prior to study entry).
- Subjects with neuropathy grade > 2 based on CTCAE v5.0 at the time of study entry.
- Subjects with uncontrolled medical or mental illness that, in the investigator's judgement, could affect treatment tolerability or compliance.
Subjects diagnosed with other malignant primary tumor with an exception of the following:
- Malignancy diagnosed at least 5 years previously without evidence of recurrence or persistent disease
- The complete excision of basal/squamous cell carcinoma or papillary thyroid carcinoma or the complete treatment of cervical intraepithelial neoplasia or other in situ carcinoma
- Subjects with symptomatic or unstable, untreated metastases to the central nervous system (CNS) at the time of screening ('Unstable' means worsening of symptoms within 4 weeks prior to screening).
- Subjects who are currently receiving alternative cytotoxic agents, regular systemic corticosteroids and medications that could influence drug absorption (e.g. H2-antihistamines, antacids, metoclopramide and charcoal) within 4 weeks prior to entry into the study (C1D1).
- Subjects who are currently receiving (or unable to stop use the 3 days before the first dose of DHP107 and throughout the study) prescription or non-prescription medications or other products known to be moderate or potent inhibitors/inducers of CYP3A4, P-gp, or CYP2C8.
- Subjects who cannot intake whole high fat meal offered.
- Pregnant or breastfeeding women.
- Subjects who have received any investigational drugs or devices within 4 weeks before the first day of study treatment (C1D1)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Fasting treatment
|
DHP107 200 mg/m2 orally twice daily on Days 1, 8, and 15 in every 28 days (On food effect study day, DHP107 200 mg/m2 orally once daily on Days 1, 8 of Cycle 1 with fasted or fed condition according to the assigned sequence)
Other Names:
|
Experimental: Fed treatment
|
DHP107 200 mg/m2 orally twice daily on Days 1, 8, and 15 in every 28 days (On food effect study day, DHP107 200 mg/m2 orally once daily on Days 1, 8 of Cycle 1 with fasted or fed condition according to the assigned sequence)
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
• Cmax
Time Frame: Day 1 and Day 8 of Cycle 1(each cycle is 28 days)
|
The primary endpoints of this trial are the ratio of geometric means of the following pharmacokinetic parameters following DHP107 administration fed with fasting condition
|
Day 1 and Day 8 of Cycle 1(each cycle is 28 days)
|
• Tmax
Time Frame: Day 1 and Day 8 of Cycle 1(each cycle is 28 days)
|
and the median difference of the following pharmacokinetic parameters following DHP107 administration fed with fasting condition:
|
Day 1 and Day 8 of Cycle 1(each cycle is 28 days)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Erika Hitre, M.D., Ph.D, National Institute of Oncology
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
January 1, 2021
Primary Completion (Anticipated)
September 1, 2021
Study Completion (Anticipated)
March 1, 2022
Study Registration Dates
First Submitted
November 23, 2020
First Submitted That Met QC Criteria
December 15, 2020
First Posted (Actual)
December 19, 2020
Study Record Updates
Last Update Posted (Actual)
December 19, 2020
Last Update Submitted That Met QC Criteria
December 15, 2020
Last Verified
December 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 107CS-7
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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