- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04944004
Effectiveness of Computer-based Cognitive Training for Executive Functions After Stroke
Objective:
To determine the efficacy of computer-based cognitive training(CBCT) in patients with stroke in the community settings.
Study Design:
Single-blinded prospective, pre-test/post-test randomized controlled trial (RCT) will be conducted in 2 groups of participants that receiving training in community settings. Treatment groups will attend individualized CBCT programme using CogniPlus® while control group will continue attend conventional treatment as usual (TAU). Assessment on the means difference in assessing functions will be done after the study.
Samples:
100 patients with stroke will be recruited from the community, using a sampling frame of selected diagnosis and homogeneity.
Expected Findings:
Find out the training effects of selected CBCT on EF and daily functioning in patients with stroke
Study Overview
Status
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Ray Li, MSc
- Phone Number: 852 98312636
- Email: rayliot@yahoo.com.hk
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients are suffered from unilateral hemispheric stroke and with a confirmation by neuroimaging evidence from either computer tomography (CT) or magnetic resonance imaging (MRI);
- Patients are either at subacute stage or chronic stage, i.e. the patients are suffered from post-stroke after one month,
- Patients are age 60 years old or above;
- Patients are medically stable;
- Patients are Cantonese speaking,
- Patients can communicate and to follow at least three-step commands, and;
- Patients are willing to give written consent.
Exclusion Criteria:
- Patients are at acute stage, i.e the patients are suffered from stroke within 1 week;
- Patients with severe aphasia, swallowing disorders or other complications post-stroke that prevent them from successfully completing the assessments;
- Patients with any previously known psychiatric disorder or neurological disease excluding stroke;
- Patients are unable to given written consent.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental CBCT Group
Participants of CBCT group will attend individual computer-based cognitive training sessions.
Researcher will give instruction in the use of the computerized training programs and assists participants during their training sessions.
|
The CBCT programmes proposed in this study is called CogniPlus.
This software package offers training of scientifically proven trainable cognitive functions.
According to the user manual, the lifelike interactive system and its automatic adaptability to client's ability level made CogniPlus feasible in community settings.
|
Active Comparator: Training As Usual (TAU) Group
Participants of TAU group will attend usual training sessions offered by the training centres with similar intensity and frequency as the CBCT training.
|
Training As Usual (TAU)
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change of Wisconsin Card Sorting Test Score
Time Frame: Baseline, after completion of half of the programme (an average of 8 weeks), one month post-treatment
|
The test consists of 128 card designs, participant is required to sort the cards under the categorization rules and feedback from examiner in about 20 minutes.
The more categories achieved (range 0 to 6) and less perseverative errors (out of 128 trials) the better executive control.
Moreover, the lower the total number of trials administered (total number of cards used) reflects greater efficiency of the participant in the task; in addition, the greater the total number of correct responses (number of successes in combinations according to the category) and the lower the total number of errors (number of incorrect combinations) also indicate the better the participant's performance.
|
Baseline, after completion of half of the programme (an average of 8 weeks), one month post-treatment
|
Collaborators and Investigators
Sponsor
Collaborators
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HongKongPolyuRL
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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