- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04994028
Effectiveness of Volume Spirometry and Deep Breathing Exercise for Dyspnea During Third Trimester of Pregnancy
August 5, 2021 updated by: Riphah International University
During pregnancy women undergoes anatomical, mechanical and physiological changes to meet the demand of growing fetus.
Dyspnea is a common complaint in pregnancy related to change in respiratory centre threshold and sensitivity.
Pregnant women who engaged in regular exercise have less pregnancy induced discomforts like dyspnea and leg cramps than who did not engage in exercise.
During pregnancy women undergoes anatomical, mechanical and physiological changes to meet the demand of growing fetus.
Purpose of this study was to evaluate the efficacy of volume Spirometry and breathing exercise on dyspnea in third trimester of pregnancy.
Rationale of the study was to find the effects of volume Spirometry and breathing exercise on dyspnea with focus on method of deep breathing exercise and volume Spirometry and outcomes.
Significance of this study was to improve functional capacity and quality of life in pregnancy induced dyspnea.
Subjects were randomly allocated to either two groups both groups received baseline treatment while interventional group received volume Spirometry and deep breathing exercise.
Estimated sample size of 48 divided into 24 in either group by randomization.
Modified Borg scale and visual analog scale were used to collect the findings.
Non-parametric tests were used and analyzed by using spss22.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
46
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Punjab
-
Dera Ghazi Khan, Punjab, Pakistan, 32200
- DHQ Teaching Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 40 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- BMI 18.5-30
- Primigravida and multigravida with 3rd trimester
- Singleton and twin pregnancy
Exclusion Criteria:
- Cardiac and respiratory disorders
- Smoker
- Obesity
- Any type of allergy
- Autoimmune disorders
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Conventional treatment
Conventional treatment that include behavioral and life style modification and dyspnea prevention education
|
Behavioral and life style modification and dyspnea prevention education i.e.
Sitting: Sit upright with back against chair, feet wide apart, leaning forward with arms on bedside table or on knees.
Standing: Lean back against wall with feet slightly apart with head and shoulder relaxed.
In Bed: Elevate head of the bed, support and elevate arms with pillow.
Stairs: Lean forward with on banister when climbing stairs.
|
Experimental: conventional treatment with volume Spirometry and deep breathing
Conventional treatment along with volume Spirometry and deep breathing exercise
|
Group B or interventional group was received conventional treatment along with volume Spirometry and deep breathing exercise, total 5 breaths with 3sec inhalational breath hold for each breath at one session per day for volume Spirometry and for deep breathing exercise 10 times with breath hold 2sec at every session for 5 minutes 3 times per week for total duration of two weeks.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Modified dyspnea Borg scale
Time Frame: 2nd week
|
Modified Borg Dyspnea Scale is most commonly used to assess symptoms of breathlessness.
It has a range from 0 to 10 (with 0 being no exertion and 10 being maximum effort).
|
2nd week
|
Modified Medical Research Council Dyspnea Scale (mMRC)
Time Frame: 2nd week
|
Questionnaire that consist of 5 statements about breathlessness.
Grade0, get breathlessness only at strenuous exercise.
Grade1, got breathlessness when hurrying on level ground.
Grade2, walk slower than the people of my age on the level.
Grade3, stop for breath after few minutes of walk on the level.
Grade4, too breathlessness to leave the house when dressing or undressing.
|
2nd week
|
London chest activity of Daily Living questionnaire (LCADL)
Time Frame: 2nd week
|
It consist of four domains Selfcare, domestic activities, physical activities and leisure activities. Selfcare, domestic, physical and leisure activities contains 4, 6, 2 and 3 items respectively. Each item is graded by numbers 0-5, 0 mean little or no dyspnea and 5 mean worst dyspnea.gy |
2nd week
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Kolomanska D, Zarawski M, Mazur-Bialy A. Physical Activity and Depressive Disorders in Pregnant Women-A Systematic Review. Medicina (Kaunas). 2019 May 26;55(5):212. doi: 10.3390/medicina55050212.
- Jensen D, Ofir D, O'Donnell DE. Effects of pregnancy, obesity and aging on the intensity of perceived breathlessness during exercise in healthy humans. Respir Physiol Neurobiol. 2009 May 30;167(1):87-100. doi: 10.1016/j.resp.2009.01.011. Epub 2009 Feb 7.
- Bidad K, Heidarnazhad H, Pourpak Z, Ramazanzadeh F, Zendehdel N, Moin M. Frequency of asthma as the cause of dyspnea in pregnancy. Int J Gynaecol Obstet. 2010 Nov;111(2):140-3. doi: 10.1016/j.ijgo.2010.05.024. Epub 2010 Aug 12.
- Chiron B, Laffon M, Ferrandiere M, Pittet JF, Marret H, Mercier C. Standard preoxygenation technique versus two rapid techniques in pregnant patients. Int J Obstet Anesth. 2004 Jan;13(1):11-4. doi: 10.1016/S0959-289X(03)00095-5.
- Nurcahyani AS, Runjati R, Nugraheni SA. Giving Belly Breathing Technique and Positive Affirmation of Stress and Cortisol Hormone Levels in Third Trimester Pregnant Women. 2020. 77. Fiskin G, Sahin NH. Effect of diaphragmatic breathing exercise on psychological parameters in gestational diabetes: A randomised controlled trial. European Journal of Integrative Medicine. 2018;23:50-6
- Armstrong CO. Post-op incentive spirometry: Why, when, & how. Nursing. 2017 Jun;47(6):54-57. doi: 10.1097/01.NURSE.0000516223.16649.02. No abstract available.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 13, 2020
Primary Completion (Actual)
June 30, 2021
Study Completion (Actual)
July 15, 2021
Study Registration Dates
First Submitted
August 5, 2021
First Submitted That Met QC Criteria
August 5, 2021
First Posted (Actual)
August 6, 2021
Study Record Updates
Last Update Posted (Actual)
August 6, 2021
Last Update Submitted That Met QC Criteria
August 5, 2021
Last Verified
August 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- REC/Lhr/20/0301 Uzma Batool
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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