- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05058651
Evaluating the Addition of the Immunotherapy Drug Atezolizumab to Standard Chemotherapy Treatment for Advanced or Metastatic Neuroendocrine Carcinomas That Originate Outside the Lung
Randomized Phase II/III Trial of First Line Platinum/Etoposide With or Without Atezolizumab (NSC#783608) in Patients With Advanced or Metastatic Poorly Differentiated Extrapulmonary Neuroendocrine Carcinomas (NEC)
Study Overview
Status
Conditions
Detailed Description
PRIMARY OBJECTIVES:
I. Compare the combination of induction platinum/etoposide and atezolizumab followed by maintenance atezolizumab (Arm 1) versus induction platinum/etoposide alone (Arm 3).
II. Compare the combination of induction platinum/etoposide and atezolizumab followed by observation (Arm 2) versus induction platinum/etoposide alone (Arm 3).
III. Compare the combination of induction platinum/etoposide and atezolizumab followed by maintenance atezolizumab (Arm 1) versus the combination of induction platinum/etoposide and atezolizumab followed by observation (Arm 2).
SECONDARY OBJECTIVES:
I. To compare overall survival (OS), measured from start of observation/maintenance, across arms.
II. To compare progression free survival (PFS) (measured from randomization and measured from start of observation/maintenance) across arms.
III. To compare objective response rate (ORR = confirmed and unconfirmed partial response [PR] + confirmed and unconfirmed complete response [CR]) across arms among patients with measurable disease at randomization.
IV. To compare clinical benefit rate (CBR = confirmed and unconfirmed PR + confirmed and unconfirmed CR + stable disease [SD]) across arms among patients with measurable disease at randomization.
V. To compare duration of response (DOR) across arms. VI. To evaluate the safety and tolerability of each arm.
ADDITIONAL OBJECTIVE:
I. To bank tumor and blood samples for future biomarker correlative studies.
OUTLINE: Patients are randomized to 1 of 3 arms.
ARM I: During induction phase, patients receive atezolizumab intravenously (IV) over 30-60 minutes on day 1 of each cycle, carboplatin IV over 30 minutes or cisplatin IV over 60 minutes on day 1 of each cycle, and etoposide IV on days 1-3 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. During maintenance phase, patients receive atezolizumab IV over 30-60 minutes on day 1 of each cycle. Treatment repeats every 21 days for up to 17 cycles in the absence of disease progression or unacceptable toxicity.
ARM II: During induction phase, patients receive atezolizumab IV over 30-60 minutes on day 1 of each cycle, carboplatin IV over 30 minutes or cisplatin IV over 60 minutes on day 1 of each cycle, and etoposide IV on days 1-3 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then undergo observation for 1 year.
ARM III: During induction phase, patients receive carboplatin IV over 30 minutes or cisplatin IV over 60 minutes on day 1 of each cycle and etoposide IV on days 1-3 of each cycle. Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity. Patients then undergo observation for 1 year.
Patients in all arms also undergo compute tomography (CT) scan and/or magnetic resonance imaging (MRI) throughout the trial and blood sample collection on study.
After completion of study treatment, patients are followed up for 5 years.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
- Phase 3
Contacts and Locations
Study Locations
-
-
Arizona
-
Phoenix, Arizona, United States, 85004
- Recruiting
- Cancer Center at Saint Joseph's
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 720-874-1881
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
-
California
-
Anaheim, California, United States, 92806
- Recruiting
- Kaiser Permanente-Anaheim
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Auburn, California, United States, 95602
- Recruiting
- Sutter Auburn Faith Hospital
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Auburn, California, United States, 95603
- Recruiting
- Sutter Cancer Centers Radiation Oncology Services-Auburn
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Baldwin Park, California, United States, 91706
- Recruiting
- Kaiser Permanente-Baldwin Park
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Bellflower, California, United States, 90706
- Recruiting
- Kaiser Permanente-Bellflower
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Berkeley, California, United States, 94704
- Recruiting
- Alta Bates Summit Medical Center-Herrick Campus
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Cameron Park, California, United States, 95682
- Recruiting
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Carmichael, California, United States, 95608
- Recruiting
- Mercy San Juan Medical Center
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 916-556-3301
- Email: OncologyResearch@DignityHealth.org
-
Carmichael, California, United States, 95608
- Recruiting
- Mercy Cancer Center - Carmichael
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 720-874-1881
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
Elk Grove, California, United States, 95758
- Recruiting
- Mercy Cancer Center - Elk Grove
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 720-874-1881
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
Fontana, California, United States, 92335
- Recruiting
- Kaiser Permanente-Fontana
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Fremont, California, United States, 94538
- Recruiting
- Palo Alto Medical Foundation-Fremont
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Harbor City, California, United States, 90710
- Recruiting
- Kaiser Permanente - Harbor City
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Irvine, California, United States, 92618
- Recruiting
- Kaiser Permanente-Irvine
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Los Angeles, California, United States, 90027
- Recruiting
- Kaiser Permanente Los Angeles Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Los Angeles, California, United States, 90034
- Recruiting
- Kaiser Permanente West Los Angeles
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Modesto, California, United States, 95355
- Recruiting
- Memorial Medical Center
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Mountain View, California, United States, 94040
- Recruiting
- Palo Alto Medical Foundation-Camino Division
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Ontario, California, United States, 91761
- Recruiting
- Kaiser Permanente-Ontario
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Palo Alto, California, United States, 94301
- Recruiting
- Palo Alto Medical Foundation Health Care
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Panorama City, California, United States, 91402
- Recruiting
- Kaiser Permanente - Panorama City
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Riverside, California, United States, 92505
- Recruiting
- Kaiser Permanente-Riverside
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Rocklin, California, United States, 95765
- Recruiting
- Mercy Cancer Center - Rocklin
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 720-874-1881
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
Roseville, California, United States, 95661
- Recruiting
- Sutter Cancer Centers Radiation Oncology Services-Roseville
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Roseville, California, United States, 95661
- Recruiting
- Sutter Roseville Medical Center
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Sacramento, California, United States, 95816
- Recruiting
- Sutter Medical Center Sacramento
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Sacramento, California, United States, 95816
- Recruiting
- Mercy Cancer Center - Sacramento
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 720-874-1881
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
San Diego, California, United States, 92120
- Recruiting
- Kaiser Permanente-San Diego Zion
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
San Francisco, California, United States, 94115
- Recruiting
- California Pacific Medical Center-Pacific Campus
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
San Marcos, California, United States, 92078
- Recruiting
- Kaiser Permanente-San Marcos
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
Santa Cruz, California, United States, 95065
- Recruiting
- Palo Alto Medical Foundation-Santa Cruz
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Sunnyvale, California, United States, 94086
- Recruiting
- Palo Alto Medical Foundation-Sunnyvale
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Vallejo, California, United States, 94589
- Recruiting
- Sutter Solano Medical Center/Cancer Center
-
Principal Investigator:
- Deepti Behl
-
Contact:
- Site Public Contact
- Email: NCIclinicaltrials@sutterhealth.org
-
Woodland, California, United States, 95695
- Recruiting
- Woodland Memorial Hospital
-
Principal Investigator:
- Shahzad Siddique
-
Contact:
- Site Public Contact
- Phone Number: 720-874-1881
- Email: ResearchInstituteInquiries@CommonSpirit.org
-
Woodland Hills, California, United States, 91367
- Recruiting
- Kaiser Permanente-Woodland Hills
-
Contact:
- Site Public Contact
- Phone Number: 800-398-3996
- Email: clinical.trials@kp.org
-
Principal Investigator:
- Helen H. Moon
-
-
Colorado
-
Parker, Colorado, United States, 80138
- Recruiting
- Parker Adventist Hospital
-
Contact:
- Site Public Contact
- Phone Number: 719-776-6550
- Email: ResearchTracking@Centura.Org
-
Principal Investigator:
- Nadine G. Mikhaeel-Kamel
-
-
Connecticut
-
Derby, Connecticut, United States, 06418
- Recruiting
- Smilow Cancer Hospital-Derby Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Fairfield, Connecticut, United States, 06824
- Recruiting
- Smilow Cancer Hospital Care Center-Fairfield
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Glastonbury, Connecticut, United States, 06033
- Recruiting
- Smilow Cancer Hospital Care Center at Glastonbury
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Greenwich, Connecticut, United States, 06830
- Recruiting
- Smilow Cancer Hospital Care Center at Greenwich
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Guilford, Connecticut, United States, 06437
- Recruiting
- Smilow Cancer Hospital Care Center - Guilford
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Hartford, Connecticut, United States, 06105
- Recruiting
- Smilow Cancer Hospital Care Center at Saint Francis
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
New Haven, Connecticut, United States, 06520
- Recruiting
- Yale University
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
North Haven, Connecticut, United States, 06473
- Recruiting
- Yale-New Haven Hospital North Haven Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Stamford, Connecticut, United States, 06902
- Recruiting
- Smilow Cancer Hospital Care Center at Long Ridge
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Torrington, Connecticut, United States, 06790
- Recruiting
- Smilow Cancer Hospital-Torrington Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Trumbull, Connecticut, United States, 06611
- Recruiting
- Smilow Cancer Hospital Care Center-Trumbull
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Waterbury, Connecticut, United States, 06708
- Recruiting
- Smilow Cancer Hospital-Waterbury Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
Waterford, Connecticut, United States, 06385
- Recruiting
- Smilow Cancer Hospital Care Center - Waterford
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
-
Florida
-
Fort Lauderdale, Florida, United States, 33308
- Recruiting
- Holy Cross Hospital
-
Principal Investigator:
- Tareq Al Baghdadi
-
Contact:
- Site Public Contact
- Email: eileen.georgi@holy-cross.com
-
Tampa, Florida, United States, 33612
- Recruiting
- Moffitt Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-679-0775
- Email: ClinicalTrials@moffitt.org
-
Principal Investigator:
- Mintallah Haider
-
-
Hawaii
-
'Aiea, Hawaii, United States, 96701
- Recruiting
- Pali Momi Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-486-6000
-
Principal Investigator:
- Elizabeth S. Nakasone
-
'Aiea, Hawaii, United States, 96701
- Recruiting
- Hawaii Cancer Care - Westridge
-
Contact:
- Site Public Contact
- Phone Number: 808-539-2273
- Email: info@hawaiicancercare.com
-
Principal Investigator:
- Elizabeth S. Nakasone
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Contact:
- Site Public Contact
- Phone Number: 808-524-6115
- Email: i.webster@hawaiicancercare.com
-
Principal Investigator:
- Elizabeth S. Nakasone
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Cancer Cenrer - POB I
-
Contact:
- Site Public Contact
- Phone Number: 808-532-0315
-
Principal Investigator:
- Elizabeth S. Nakasone
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-545-8548
-
Principal Investigator:
- Elizabeth S. Nakasone
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Straub Clinic and Hospital
-
Contact:
- Site Public Contact
- Phone Number: 808-522-4333
-
Principal Investigator:
- Elizabeth S. Nakasone
-
Honolulu, Hawaii, United States, 96817
- Recruiting
- Queen's Cancer Center - Kuakini
-
Contact:
- Site Public Contact
- Phone Number: 808-531-8521
-
Principal Investigator:
- Elizabeth S. Nakasone
-
-
Illinois
-
Centralia, Illinois, United States, 62801
- Recruiting
- Centralia Oncology Clinic
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Chicago, Illinois, United States, 60637
- Recruiting
- University of Chicago Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Ardaman Shergill
-
Chicago, Illinois, United States, 60611
- Recruiting
- Northwestern University
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Phone Number: 312-695-1301
- Email: cancer@northwestern.edu
-
Danville, Illinois, United States, 61832
- Recruiting
- Carle at The Riverfront
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Vamsi K. Vasireddy
-
DeKalb, Illinois, United States, 60115
- Recruiting
- Northwestern Medicine Cancer Center Kishwaukee
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Decatur, Illinois, United States, 62526
- Recruiting
- Cancer Care Specialists of Illinois - Decatur
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Decatur, Illinois, United States, 62526
- Recruiting
- Decatur Memorial Hospital
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Effingham, Illinois, United States, 62401
- Recruiting
- Carle Physician Group-Effingham
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Vamsi K. Vasireddy
-
Effingham, Illinois, United States, 62401
- Recruiting
- Crossroads Cancer Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Geneva, Illinois, United States, 60134
- Recruiting
- Northwestern Medicine Cancer Center Delnor
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
Glenview, Illinois, United States, 60026
- Recruiting
- Northwestern Medicine Glenview Outpatient Center
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Phone Number: 312-695-1102
-
Grayslake, Illinois, United States, 60030
- Recruiting
- Northwestern Medicine Grayslake Outpatient Center
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Phone Number: 312-695-1102
-
Harvey, Illinois, United States, 60426
- Recruiting
- Ingalls Memorial Hospital
-
Contact:
- Site Public Contact
- Phone Number: 708-915-4673
- Email: clinicaltrials@ingalls.org
-
Principal Investigator:
- Mark F. Kozloff
-
Lake Forest, Illinois, United States, 60045
- Recruiting
- Northwestern Medicine Lake Forest Hospital
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Email: cancertrials@northwestern.edu
-
Mattoon, Illinois, United States, 61938
- Recruiting
- Carle Physician Group-Mattoon/Charleston
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Vamsi K. Vasireddy
-
New Lenox, Illinois, United States, 60451
- Recruiting
- UC Comprehensive Cancer Center at Silver Cross
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Ardaman Shergill
-
O'Fallon, Illinois, United States, 62269
- Recruiting
- Cancer Care Center of O'Fallon
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-876-4762
- Email: morganthaler.jodi@mhsil.com
-
Orland Park, Illinois, United States, 60462
- Recruiting
- University of Chicago Medicine-Orland Park
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Ardaman Shergill
-
Orland Park, Illinois, United States, 60462
- Recruiting
- Northwestern Medicine Orland Park
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Email: nctnprogram_rhlccc@northwestern.edu
-
Springfield, Illinois, United States, 62702
- Recruiting
- Southern Illinois University School of Medicine
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-545-7929
-
Springfield, Illinois, United States, 62702
- Recruiting
- Springfield Clinic
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 800-444-7541
-
Springfield, Illinois, United States, 62781
- Recruiting
- Memorial Medical Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 217-528-7541
- Email: pallante.beth@mhsil.com
-
Urbana, Illinois, United States, 61801
- Recruiting
- Carle Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Vamsi K. Vasireddy
-
Warrenville, Illinois, United States, 60555
- Recruiting
- Northwestern Medicine Cancer Center Warrenville
-
Principal Investigator:
- Mary F. Mulcahy
-
Contact:
- Site Public Contact
- Phone Number: 630-352-5360
- Email: Donald.Smith3@nm.org
-
-
Iowa
-
Ames, Iowa, United States, 50010
- Recruiting
- Mary Greeley Medical Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Ames, Iowa, United States, 50010
- Recruiting
- McFarland Clinic - Ames
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-239-4734
- Email: ksoder@mcfarlandclinic.com
-
Ankeny, Iowa, United States, 50023
- Recruiting
- Mission Cancer and Blood - Ankeny
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-282-2921
-
Boone, Iowa, United States, 50036
- Recruiting
- McFarland Clinic - Boone
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Clive, Iowa, United States, 50325
- Recruiting
- Medical Oncology and Hematology Associates-West Des Moines
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Principal Investigator:
- Richard L. Deming
-
Clive, Iowa, United States, 50325
- Recruiting
- Mercy Cancer Center-West Lakes
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
Creston, Iowa, United States, 50801
- Recruiting
- Greater Regional Medical Center
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
Des Moines, Iowa, United States, 50309
- Recruiting
- Medical Oncology and Hematology Associates-Des Moines
-
Principal Investigator:
- Joshua Lukenbill
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Des Moines, Iowa, United States, 50314
- Recruiting
- Mercy Medical Center - Des Moines
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
Des Moines, Iowa, United States, 50314
- Recruiting
- Mission Cancer and Blood - Laurel
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Principal Investigator:
- Richard L. Deming
-
Fort Dodge, Iowa, United States, 50501
- Recruiting
- McFarland Clinic - Trinity Cancer Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Jefferson, Iowa, United States, 50129
- Recruiting
- McFarland Clinic - Jefferson
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Marshalltown, Iowa, United States, 50158
- Recruiting
- McFarland Clinic - Marshalltown
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
West Des Moines, Iowa, United States, 50266
- Recruiting
- Mercy Medical Center-West Lakes
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
-
Louisiana
-
Baton Rouge, Louisiana, United States, 70805
- Recruiting
- LSU Health Baton Rouge-North Clinic
-
Contact:
- Site Public Contact
- Phone Number: 225-765-7659
- Email: research@ololrmc.com
-
Principal Investigator:
- Marshall P. Stagg
-
Baton Rouge, Louisiana, United States, 70809
- Recruiting
- Our Lady of the Lake Physicians Group - Medical Oncology
-
Contact:
- Site Public Contact
- Phone Number: 225-765-7659
- Email: research@ololrmc.com
-
Principal Investigator:
- Marshall P. Stagg
-
New Orleans, Louisiana, United States, 70112
- Recruiting
- University Medical Center New Orleans
-
Contact:
- Site Public Contact
- Phone Number: 504-210-3539
- Email: emede1@lsuhsc.edu
-
Principal Investigator:
- Tara Castellano
-
-
Michigan
-
Ann Arbor, Michigan, United States, 48106
- Recruiting
- Saint Joseph Mercy Hospital
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Ann Arbor, Michigan, United States, 48109
- Recruiting
- University of Michigan Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-865-1125
-
Principal Investigator:
- Vaibhav Sahai
-
Brighton, Michigan, United States, 48114
- Recruiting
- Saint Joseph Mercy Brighton
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Brighton, Michigan, United States, 48114
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Brownstown, Michigan, United States, 48183
- Recruiting
- Henry Ford Cancer Institute-Downriver
-
Contact:
- Site Public Contact
- Phone Number: 313-916-3721
- Email: CTOResearch@hfhs.org
-
Principal Investigator:
- Haythem Y. Ali
-
Canton, Michigan, United States, 48188
- Recruiting
- Saint Joseph Mercy Canton
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Canton, Michigan, United States, 48188
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Chelsea, Michigan, United States, 48118
- Recruiting
- Saint Joseph Mercy Chelsea
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Chelsea, Michigan, United States, 48118
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Clinton Township, Michigan, United States, 48038
- Recruiting
- Henry Ford Macomb Hospital-Clinton Township
-
Contact:
- Site Public Contact
- Phone Number: 313-916-3721
- Email: CTOResearch@hfhs.org
-
Principal Investigator:
- Haythem Y. Ali
-
Dearborn, Michigan, United States, 48124
- Recruiting
- Beaumont Hospital - Dearborn
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Andrew A. Muskovitz
-
Detroit, Michigan, United States, 48236
- Recruiting
- Ascension Saint John Hospital
-
Contact:
- Site Public Contact
- Phone Number: 313-343-3166
- Email: karen.forman@ascension.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Detroit, Michigan, United States, 48201
- Recruiting
- Wayne State University/Karmanos Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Principal Investigator:
- Mohammed N. Al Hallak
-
Detroit, Michigan, United States, 48202
- Recruiting
- Henry Ford Hospital
-
Contact:
- Site Public Contact
- Phone Number: 313-916-3721
- Email: CTOResearch@hfhs.org
-
Principal Investigator:
- Haythem Y. Ali
-
Farmington Hills, Michigan, United States, 48334
- Recruiting
- Weisberg Cancer Treatment Center
-
Contact:
- Site Public Contact
- Phone Number: 313-576-9790
- Email: ctoadmin@karmanos.org
-
Principal Investigator:
- Mohammed N. Al Hallak
-
Farmington Hills, Michigan, United States, 48336
- Recruiting
- Beaumont Hospital - Farmington Hills
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Andrew A. Muskovitz
-
Flint, Michigan, United States, 48503
- Recruiting
- Genesee Cancer and Blood Disease Treatment Center
-
Contact:
- Site Public Contact
- Phone Number: 810-762-8038
- Email: wstrong@ghci.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Flint, Michigan, United States, 48503
- Recruiting
- Genesee Hematology Oncology PC
-
Contact:
- Site Public Contact
- Phone Number: 810-762-8038
- Email: wstrong@ghci.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Flint, Michigan, United States, 48503
- Recruiting
- Genesys Hurley Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 810-762-8038
- Email: wstrong@ghci.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Flint, Michigan, United States, 48503
- Recruiting
- Hurley Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 810-762-8038
- Email: wstrong@ghci.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Livonia, Michigan, United States, 48154
- Recruiting
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Royal Oak, Michigan, United States, 48073
- Recruiting
- William Beaumont Hospital-Royal Oak
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Andrew A. Muskovitz
-
Troy, Michigan, United States, 48085
- Recruiting
- William Beaumont Hospital - Troy
-
Contact:
- Site Public Contact
- Phone Number: 248-551-7695
-
Principal Investigator:
- Andrew A. Muskovitz
-
Warren, Michigan, United States, 48093
- Recruiting
- Saint John Macomb-Oakland Hospital
-
Contact:
- Site Public Contact
- Phone Number: 313-343-3166
- Email: karen.forman@ascension.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Ypsilanti, Michigan, United States, 48106
- Recruiting
- Huron Gastroenterology PC
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
Ypsilanti, Michigan, United States, 48197
- Recruiting
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Contact:
- Site Public Contact
- Phone Number: 734-712-7251
- Email: MCRCwebsitecontactform@stjoeshealth.org
-
Principal Investigator:
- Tareq Al Baghdadi
-
-
Minnesota
-
Duluth, Minnesota, United States, 55805
- Active, not recruiting
- Saint Luke's Hospital of Duluth
-
Edina, Minnesota, United States, 55435
- Recruiting
- Fairview Southdale Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
Minneapolis, Minnesota, United States, 55407
- Recruiting
- Abbott-Northwestern Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
Rochester, Minnesota, United States, 55905
- Recruiting
- Mayo Clinic in Rochester
-
Principal Investigator:
- Jacob Orme
-
Contact:
- Site Public Contact
- Phone Number: 855-776-0015
-
Saint Louis Park, Minnesota, United States, 55416
- Recruiting
- Park Nicollet Clinic - Saint Louis Park
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
Saint Paul, Minnesota, United States, 55101
- Recruiting
- Regions Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
-
Missouri
-
Cape Girardeau, Missouri, United States, 63703
- Recruiting
- Saint Francis Medical Center
-
Principal Investigator:
- Bryan A. Faller
-
Contact:
- Site Public Contact
- Phone Number: 573-334-2230
- Email: sfmc@sfmc.net
-
Joplin, Missouri, United States, 64804
- Recruiting
- Mercy Hospital Joplin
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 417-556-3074
- Email: esmeralda.carrillo@mercy.net
-
Springfield, Missouri, United States, 65807
- Recruiting
- CoxHealth South Hospital
-
Principal Investigator:
- Jay W. Carlson
-
Contact:
- Site Public Contact
- Phone Number: 417-269-4520
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Recruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-639-6918
- Email: cancer.research.nurse@dartmouth.edu
-
Principal Investigator:
- Kathryn C. Hourdequin
-
-
New York
-
Buffalo, New York, United States, 14263
- Recruiting
- Roswell Park Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 800-767-9355
- Email: askroswell@roswellpark.org
-
Principal Investigator:
- Renuka V. Iyer
-
New York, New York, United States, 10029
- Recruiting
- Mount Sinai Hospital
-
Contact:
- Site Public Contact
- Phone Number: 212-824-7309
- Email: CCTO@mssm.edu
-
Principal Investigator:
- Edward M. Wolin
-
Stony Brook, New York, United States, 11794
- Recruiting
- Stony Brook University Medical Center
-
Principal Investigator:
- Julie Anne L. Gemmill
-
Contact:
- Site Public Contact
- Phone Number: 800-862-2215
-
-
North Carolina
-
Charlotte, North Carolina, United States, 28203
- Recruiting
- Carolinas Medical Center/Levine Cancer Institute
-
Principal Investigator:
- Earle F. Burgess
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Charlotte, North Carolina, United States, 28211
- Recruiting
- Levine Cancer Institute-SouthPark
-
Principal Investigator:
- Earle F. Burgess
-
Contact:
- Site Public Contact
- Phone Number: 980-442-2000
-
Charlotte, North Carolina, United States, 28262
- Recruiting
- Atrium Health University City/LCI-University
-
Principal Investigator:
- Earle F. Burgess
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Charlotte, North Carolina, United States, 28277
- Recruiting
- Levine Cancer Institute-Ballantyne
-
Principal Investigator:
- Earle F. Burgess
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Clinton, North Carolina, United States, 28328
- Recruiting
- Southeastern Medical Oncology Center-Clinton
-
Contact:
- Site Public Contact
- Phone Number: 919-587-9084
- Email: jfields@cancersmoc.com
-
Principal Investigator:
- Samer S. Kasbari
-
Concord, North Carolina, United States, 28025
- Recruiting
- Atrium Health Cabarrus/LCI-Concord
-
Principal Investigator:
- Earle F. Burgess
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Gastonia, North Carolina, United States, 28054
- Recruiting
- Levine Cancer Institute-Gaston
-
Principal Investigator:
- Earle F. Burgess
-
Contact:
- Site Public Contact
- Phone Number: 800-804-9376
-
Goldsboro, North Carolina, United States, 27534
- Recruiting
- Southeastern Medical Oncology Center-Goldsboro
-
Contact:
- Site Public Contact
- Phone Number: 919-587-9084
- Email: jfields@cancersmoc.com
-
Principal Investigator:
- Samer S. Kasbari
-
Jacksonville, North Carolina, United States, 28546
- Recruiting
- Southeastern Medical Oncology Center-Jacksonville
-
Principal Investigator:
- Samer S. Kasbari
-
Contact:
- Site Public Contact
- Phone Number: 910-587-9084
- Email: jfields@cancersmoc.com
-
Pinehurst, North Carolina, United States, 28374
- Recruiting
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Contact:
- Site Public Contact
- Phone Number: 910-715-3500
- Email: jcwilliams@firsthealth.org
-
Principal Investigator:
- Charles S. Kuzma
-
-
Ohio
-
Columbus, Ohio, United States, 43210
- Recruiting
- Ohio State University Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-293-5066
- Email: Jamesline@osumc.edu
-
Principal Investigator:
- Bhavana Konda
-
Toledo, Ohio, United States, 43623
- Recruiting
- Toledo Clinic Cancer Centers-Toledo
-
Principal Investigator:
- Rex B. Mowat
-
Contact:
- Site Public Contact
- Phone Number: 800-444-3561
-
-
Oklahoma
-
Lawton, Oklahoma, United States, 73505
- Recruiting
- Cancer Centers of Southwest Oklahoma Research
-
Contact:
- Site Public Contact
- Phone Number: 877-231-4440
-
Principal Investigator:
- Sagila George
-
Oklahoma City, Oklahoma, United States, 73104
- Recruiting
- University of Oklahoma Health Sciences Center
-
Contact:
- Site Public Contact
- Phone Number: 405-271-8777
- Email: ou-clinical-trials@ouhsc.edu
-
Principal Investigator:
- Sagila George
-
-
Oregon
-
Clackamas, Oregon, United States, 97015
- Recruiting
- Providence Cancer Institute Clackamas Clinic
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Charles W. Drescher
-
Newberg, Oregon, United States, 97132
- Recruiting
- Providence Newberg Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Charles W. Drescher
-
Oregon City, Oregon, United States, 97045
- Recruiting
- Providence Willamette Falls Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Charles W. Drescher
-
Portland, Oregon, United States, 97213
- Recruiting
- Providence Portland Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Charles W. Drescher
-
Portland, Oregon, United States, 97225
- Recruiting
- Providence Saint Vincent Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Principal Investigator:
- Charles W. Drescher
-
-
Rhode Island
-
Westerly, Rhode Island, United States, 02891
- Recruiting
- Smilow Cancer Hospital Care Center - Westerly
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Matthew Austin
-
-
South Carolina
-
Charleston, South Carolina, United States, 29425
- Recruiting
- Medical University of South Carolina
-
Principal Investigator:
- Paul E. O'Brien
-
Contact:
- Site Public Contact
- Phone Number: 843-792-9321
- Email: hcc-clinical-trials@musc.edu
-
-
Tennessee
-
Nashville, Tennessee, United States, 37232
- Recruiting
- Vanderbilt University/Ingram Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-811-8480
-
Principal Investigator:
- Robert A. Ramirez
-
-
Texas
-
Dallas, Texas, United States, 75390
- Recruiting
- UT Southwestern/Simmons Cancer Center-Dallas
-
Contact:
- Site Public Contact
- Phone Number: 214-648-7097
- Email: canceranswerline@UTSouthwestern.edu
-
Principal Investigator:
- Namrata I. Peswani
-
Dallas, Texas, United States, 75237
- Recruiting
- UT Southwestern Simmons Cancer Center - RedBird
-
Contact:
- Site Public Contact
- Phone Number: 214-648-7097
- Email: canceranswerline@UTSouthwestern.edu
-
Principal Investigator:
- Namrata I. Peswani
-
Fort Worth, Texas, United States, 76104
- Recruiting
- UT Southwestern/Simmons Cancer Center-Fort Worth
-
Contact:
- Site Public Contact
- Phone Number: 214-648-7097
- Email: canceranswerline@UTSouthwestern.edu
-
Principal Investigator:
- Namrata I. Peswani
-
Richardson, Texas, United States, 75080
- Recruiting
- UT Southwestern Clinical Center at Richardson/Plano
-
Contact:
- Site Public Contact
- Phone Number: 972-669-7044
- Email: Suzanne.cole@utsouthwestern.edu
-
Principal Investigator:
- Namrata I. Peswani
-
-
Utah
-
Salt Lake City, Utah, United States, 84112
- Recruiting
- Huntsman Cancer Institute/University of Utah
-
Contact:
- Site Public Contact
- Phone Number: 888-424-2100
- Email: cancerinfo@hci.utah.edu
-
Principal Investigator:
- Heloisa P. Soares
-
-
Vermont
-
Saint Johnsbury, Vermont, United States, 05819
- Recruiting
- Norris Cotton Cancer Center-North
-
Contact:
- Site Public Contact
- Phone Number: 800-639-6918
- Email: cancer.research.nurse@hitchcock.org
-
Principal Investigator:
- Kathryn C. Hourdequin
-
-
Washington
-
Seattle, Washington, United States, 98109
- Recruiting
- FHCC South Lake Union
-
Contact:
- Site Public Contact
- Phone Number: 800-804-8824
-
Principal Investigator:
- David B. Zhen
-
Seattle, Washington, United States, 98109
- Recruiting
- Fred Hutchinson Cancer Research Center
-
Contact:
- Site Public Contact
- Phone Number: 800-804-8824
-
Principal Investigator:
- David B. Zhen
-
Seattle, Washington, United States, 98195
- Recruiting
- University of Washington Medical Center - Montlake
-
Contact:
- Site Public Contact
- Phone Number: 800-804-8824
-
Principal Investigator:
- David B. Zhen
-
-
West Virginia
-
Morgantown, West Virginia, United States, 26506
- Recruiting
- West Virginia University Healthcare
-
Contact:
- Site Public Contact
- Phone Number: 304-293-7374
- Email: cancertrialsinfo@hsc.wvu.edu
-
Principal Investigator:
- Nour Daboul
-
-
Wisconsin
-
Eau Claire, Wisconsin, United States, 54701
- Recruiting
- Marshfield Medical Center-EC Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-782-8581
- Email: oncology.clinical.trials@marshfieldresearch.org
-
Principal Investigator:
- Dean A. Delmastro
-
La Crosse, Wisconsin, United States, 54601
- Recruiting
- Gundersen Lutheran Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 608-775-2385
- Email: cancerctr@gundersenhealth.org
-
Principal Investigator:
- David E. Marinier
-
Marshfield, Wisconsin, United States, 54449
- Recruiting
- Marshfield Medical Center-Marshfield
-
Contact:
- Site Public Contact
- Phone Number: 800-782-8581
- Email: oncology.clinical.trials@marshfieldresearch.org
-
Principal Investigator:
- Dean A. Delmastro
-
Minocqua, Wisconsin, United States, 54548
- Recruiting
- Marshfield Clinic-Minocqua Center
-
Contact:
- Site Public Contact
- Phone Number: 800-782-8581
- Email: oncology.clinical.trials@marshfieldresearch.org
-
Principal Investigator:
- Dean A. Delmastro
-
Rice Lake, Wisconsin, United States, 54868
- Recruiting
- Marshfield Medical Center-Rice Lake
-
Contact:
- Site Public Contact
- Phone Number: 800-782-8581
- Email: oncology.clinical.trials@marshfieldresearch.org
-
Principal Investigator:
- Dean A. Delmastro
-
Stevens Point, Wisconsin, United States, 54482
- Recruiting
- Marshfield Medical Center-River Region at Stevens Point
-
Contact:
- Site Public Contact
- Phone Number: 800-782-8581
- Email: oncology.clinical.trials@marshfieldresearch.org
-
Principal Investigator:
- Dean A. Delmastro
-
Weston, Wisconsin, United States, 54476
- Recruiting
- Marshfield Medical Center - Weston
-
Contact:
- Site Public Contact
- Phone Number: 800-782-8581
- Email: oncology.clinical.trials@marshfieldresearch.org
-
Principal Investigator:
- Dean A. Delmastro
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Participants must have histologically-confirmed (local site pathological confirmation sufficient) extrapulmonary poorly differentiated, neuroendocrine carcinoma (NEC)
- Participants must have disease that is unresectable or metastatic and not eligible for definitive therapy as deemed per the treating investigator
- Participants must have radiologically evaluable disease, measurable or non-measurable, per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. All measurable and non-measurable lesions must be assessed by CT scan with IV contrast of the chest/abdomen/and pelvis (or CT chest without contrast and MRI abdomen/pelvis with gadolinium contrast, if contraindication to CT iodinated contrast) within 28 days prior to registration. While may be used for routine clinical evaluation, PET scans and bone scans alone are not acceptable for disease assessment while participating in this study. All known sites of disease must be assessed and documented on the Baseline Tumor Assessment Form
Participants must have brain MRI (or CT head with contrast if there is contraindication to MRI brain) if clinically indicated within 28 days prior to registration. Note: Brain imaging is not required in participants without known and/or clinical concern for brain metastases. Participants with asymptomatic central nervous system (CNS) metastases are eligible if one or more of the following apply:
Participants who have received treatment for brain metastases must have:
- No evidence of radiological progression (by MRI brain or CT head with contrast if there is contraindication to MRI brain) within 28 days prior to registration
- Discontinued all corticosteroids at least 14 days prior to registration
Participants with treatment-naive brain lesions must have:
- No lesion measuring > 2.0 cm in size in any axis
- MRI brain or CT head with contrast (if there is contraindication to MRI brain) demonstrating no evidence for mass effect, edema, or other impending neurological compromise within 28 days prior to registration
- No evidence of radiological progression (by MRI brain or CT head with contrast if there is contraindication to MRI brain) within 28 days prior to registration
- No need for > 2 mg of dexamethasone (or equivalent of > 10 mg prednisone) per day at time of registration
- Participants must not have symptomatic central nervous system (CNS) metastases
- Participants must not have known or suspected leptomeningeal disease
- Participants with prior history of non-metastatic (localized/locally advanced disease) extrapulmonary poorly differentiated NEC may have had prior platinum-based therapy +/- radiation +/- surgery provided that all therapy was completed >= 6 months prior to registration
- Participants must discontinue denosumab prior to study registration and plan to replace with a bisphosphonate while on the study
- Participants must not have had prior treatment for advanced or metastatic NEC EXCEPT one cycle of platinum (carboplatin/cisplatin) + etoposide is allowed prior to registration. Other chemotherapy regimens are not allowed. For participants with prostate or urothelial NEC, prior chemotherapy for the non-NEC component (e.g. adenocarcinoma or urothelial) is allowed as long as such therapy was completed >= 24 weeks prior to registration and participants have recovered from all prior toxicities to =< grade 1.
- Participants must not have had prior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2, CD137 agonists, anti-CTLA-4 agent, or any other immune checkpoint inhibitors for any neuroendocrine neoplasm. Immune checkpoint inhibitors given for other cancer indications are allowed provided last therapy was given at least 12 months prior to study registration
- Participants must not have received treatment with systemic immunostimulatory agents including, but not limited to, interferon and interleukin2 [IL-2] within 4 weeks or 5 half-lives of the drug (whichever is longer) prior to registration
- Participants must not have had history of known severe allergy, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies, including to Chinese hamster ovary cell products or to any component of the atezolizumab formulation, cisplatin, carboplatin, or etoposide
- Participants must not be on active systemic therapy for another cancer with the exception of hormonal therapy including androgen deprivation therapy (e.g., gonadotropin-releasing hormone [GnRH] agonists or antagonists), which can be continued while participants are receiving protocol therapy. Use of enzalutamide or apalutamide is permitted after completion of chemotherapy and must be held during chemotherapy for participants receiving prior to enrollment. Use of darolutamide is permitted during chemotherapy. Glucocorticoid-containing regimens, including abiraterone, are not permitted.
- Participants must be >= 18 years of age
- Participants must have a Zubrod performance status of =< 2 within 28 days prior to registration
- Participants must have a complete medical history and physical exam within 28 days prior to registration
- Absolute neutrophil count (ANC) >= 1.5 x 10^9 /L (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Hemoglobin >= 9.0 g/dl (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Platelet count >= 100 x 10^9/L (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) =< 2.5 x institutional upper limit of normal (ULN) (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Serum total bilirubin =< 1.5 x ULN (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Adequate renal function as defined by any 1 of the following: 1) Measured creatinine clearance (CL) > 50 mL/min OR 2) Calculated creatinine CL > 50 mL/min by the Cockcroft-Gault formula OR by 24-hour urine collection for determination of creatinine clearance (obtained within 14 days prior to registration. For participants who received a cycle of chemotherapy prior to registration, at least 21 days must have elapsed between day 1 of platinum + etoposide and performance of these tests)
- Participants must not have uncontrolled or symptomatic hypercalcemia (> 1.5 mmol/L ionized calcium or calcium > 12 mg/dL or corrected serum calcium > ULN) within 14 days prior to registration. Participants who have asymptomatic hypercalcemia are eligible provided that medical therapy to treat the hypercalcemia is planned
- Participants must not have a diagnosis of immunodeficiency nor be receiving systemic steroid therapy (equivalent of > 20 mg of hydrocortisone per day) or any other form of immunosuppressive therapy within 14 days prior to registration
Participants must not have active or history of autoimmune disease or immune deficiency, including, but not limited to myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjogren syndrome, Guillain-Barre syndrome, or multiple sclerosis with the following exceptions:
- Patients with a history of autoimmune-related hypothyroidism who are on thyroid-replacement hormone are eligible for the study
- Patients with controlled type 1 diabetes mellitus who are on an insulin regimen are eligible for the study
Patients with eczema, psoriasis, lichen simplex chronicus, or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis are excluded) are eligible for the study provided all of following conditions are met:
- Rash must cover < 10% of body surface area
- Disease is well controlled at baseline and requires only low-potency topical corticosteroids
- No occurrence of acute exacerbations of the underlying condition requiring psoralen plus ultraviolet A radiation, methotrexate, retinoids, biologic agents, oral calcineurin inhibitors, or high-potency or oral corticosteroids within the previous 12 months
- Participants must not have history of idiopathic pulmonary fibrosis, organizing pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening chest CT scan. NOTE: History of radiation pneumonitis in the radiation field (fibrosis) is permitted
- Participants must not have significant cardiovascular disease, such as New York Heart Association class II or greater cardiac disease, myocardial infarction within 3 months prior to registration, unstable arrythmias, or unstable angina
- Participants must not have had a major surgical procedure other than for diagnosis within 28 days prior to registration. Participant must not plan to receive a major surgical procedure during the course of protocol treatment. NOTE: Patient port placement is not considered a major surgery
- Participants must not have severe infections (i.e., Common Terminology Criteria for Adverse Events [CTCAE] grade >= 2) at time of registration, including but not limited to hospitalization for complications for infection, bacteremia, or severe pneumonia
- Participants must not have known active tuberculosis
- Participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load, with testing performed as clinically indicated
- Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. Participants with active HCV infection who are currently on treatment must have an undetectable HCV viral load, with testing performed as clinically indicated
- Participants with known human immunodeficiency virus (HIV)-infection must be on effective anti-retroviral therapy at time of registration and have undetectable HIV viral load within 6 months of registration
- Participants must not have prior allogeneic bone marrow transplantation or solid organ transplant
- Participants must not have received administration of a live, attenuated vaccine (e.g., FluMist [registered trademark]) within 28 days prior to initiation of study treatment, during treatment with atezolizumab, and not plan to receive for 5 months after the last dose of atezolizumab
- Participants must not be pregnant due to the possibility of harm to the fetus. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method (with details provided as a part of the consent process) during the treatment period and for 5 months after the final dose of atezolizumab. A person who has had menses at any time in the preceding 12 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen
- Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) Specimen Tracking System
- Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Arm I (atezolizumab, platinum drug, etoposide)
During induction phase, patients receive atezolizumab IV over 30-60 minutes on day 1 of each cycle, carboplatin IV over 30 minutes or cisplatin IV over 60 minutes on day 1 of each cycle, and etoposide IV on days 1-3 of each cycle.
Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
During maintenance phase, patients receive atezolizumab IV over 30-60 minutes on day 1 of each cycle.
Treatment repeats every 21 days for up to 17 cycles in the absence of disease progression or unacceptable toxicity.
Patients also undergo CT scan and/or MRI throughout the trial and blood sample collection on study.
|
Given IV
Other Names:
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Undergo blood sample collection
Other Names:
Given IV
Other Names:
Undergo CT scan
Other Names:
|
Experimental: Arm II (atezolizumab, platinum drug, etoposide, observation)
During induction phase, patients receive atezolizumab IV over 30-60 minutes on day 1 of each cycle, carboplatin IV over 30 minutes or cisplatin IV over 60 minutes on day 1 of each cycle, and etoposide IV on days 1-3 of each cycle.
Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
Patients then undergo observation for 1 year.
Patients also undergo CT scan and/or MRI throughout the trial and blood sample collection on study.
|
Given IV
Other Names:
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Undergo blood sample collection
Other Names:
Given IV
Other Names:
Undergo CT scan
Other Names:
Undergo observation
Other Names:
|
Active Comparator: Arm III (platinum drug, etoposide, observation)
During induction phase, patients receive carboplatin IV over 30 minutes or cisplatin IV over 60 minutes on day 1 of each cycle and etoposide IV on days 1-3 of each cycle.
Treatment repeats every 21 days for 4 cycles in the absence of disease progression or unacceptable toxicity.
Patients then undergo observation for 1 year.
Patients also undergo CT scan and/or MRI throughout the trial and blood sample collection on study.
|
Given IV
Other Names:
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Undergo blood sample collection
Other Names:
Undergo CT scan
Other Names:
Undergo observation
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overall survival
Time Frame: From date of registration or from date of start of observation/maintenance therapy to date of death due to any cause, assessed up to 5 years
|
Log-rank tests stratified by the randomization stratification factors will be used for null hypothesis (efficacy) tests.
Cox regression models stratified by the randomization stratification factors will be used for alternative hypothesis (futility) tests.
|
From date of registration or from date of start of observation/maintenance therapy to date of death due to any cause, assessed up to 5 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Progression-free survival
Time Frame: From date of registration or start of observation/maintenance therapy to date of first documentation of progression or symptomatic deterioration, or death due to any cause, assessed up to 5 years
|
Will be estimated using the Kaplan-Meier method and compared using log-rank tests.
|
From date of registration or start of observation/maintenance therapy to date of first documentation of progression or symptomatic deterioration, or death due to any cause, assessed up to 5 years
|
Duration of response
Time Frame: Time from date of initial response to date of progression or death, assessed up to 5 years
|
Will be estimated non-parametrically using cumulative incidence curves.
|
Time from date of initial response to date of progression or death, assessed up to 5 years
|
Clinical benefit rate (confirmed CR or PR of any amount of time or stable disease for 6 months or longer)
Time Frame: Up to 5 years from study enrollment
|
Will be tabulated and compared between arms using Fisher's exact test.
|
Up to 5 years from study enrollment
|
Objective response rate (confirmed complete response [CR] or partial response [PR])
Time Frame: Up to 5 years from study enrollment
|
Will be tabulated and compared between arms using Fisher's exact test.
|
Up to 5 years from study enrollment
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: David B Zhen, SWOG Cancer Research Network
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Neoplasms by Histologic Type
- Neoplasms
- Adenocarcinoma
- Neoplasms, Glandular and Epithelial
- Neuroectodermal Tumors
- Neoplasms, Germ Cell and Embryonal
- Neoplasms, Nerve Tissue
- Neuroendocrine Tumors
- Carcinoma
- Carcinoma, Neuroendocrine
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Enzyme Inhibitors
- Antineoplastic Agents
- Immunologic Factors
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Antineoplastic Agents, Phytogenic
- Topoisomerase II Inhibitors
- Topoisomerase Inhibitors
- Antineoplastic Agents, Immunological
- Dermatologic Agents
- Immune Checkpoint Inhibitors
- Keratolytic Agents
- Carboplatin
- Etoposide
- Etoposide phosphate
- Cisplatin
- Podophyllotoxin
- Antibodies, Monoclonal
- Atezolizumab
Other Study ID Numbers
- NCI-2021-09851 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180888 (U.S. NIH Grant/Contract)
- S2012 (Other Identifier: CTEP)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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