- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05159141
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Research content 1.1 Study on the Reliability and Validity of Daily Circadian Rhythm of Infant and Young Child Behavior and Establishment of Circadian Circadian Rhythm Prediction Model In three study communities, 10 infants aged 4 months, 6 months, 12 months and 2 years old were recruited, with a total of 120 infants. Daily rhythms of sleep, activity, illumination and eating were collected by using portable device Actiwatch-2 and daily log book. Saliva at 7 time points (09: 00, 13: 00, 17: 00, 21: 00, 01: 00, 05: 00 and 09: 00) were collected to determine the level of melatonin as the gold standard for circadian rhythm of biological clocks under natural environment. The correlation between daily circadian rhythms and characteristics of melatonin secretion was determined. A model with high reliability was established by mathematical modeling.
1.2 Multicenter Cohort Study of Effects of Sleep Intervention on Metabolic Function in Childhood Obesity Methods: A 1: 1 parallel multicenter randomized controlled trial was conducted to recruit 80 infants from each of the control group and the intervention group at 28 days after birth. The control group was followed up for 5 times (28 days, 2 months, 4 months, 6 months and 12 months) of evidence-based infant sleep intervention on the basis of routine child care, and followed up until 2 years old. The main outcomes were changes in BMI z at 0-6 months of age and metabolic markers of obesity at 2 years of age, such as BMI z, subcutaneous fat, body composition and blood biochemistry. On the basis of descriptive analysis, the effects of sleep intervention on infant obesity metabolism and daily rhythm were determined, and the causal mechanism of circadian rhythm, obesity metabolic index and other factors were determined by using Bayesian causal network.
1.3 Verification of Predictive Models for Circadian Rhythms of Behavioral Clocks In the second part of the three study communities, the two groups were randomly selected 20 cases, a total of 120 infants and children.
At 4 months, 6 months, 12 months and 2 years of age after birth, saliva samples were collected at 2 time points in addition to Actiwatch-2 and daily rhythm data, and melatonin levels were measured to validate the rhythm prediction model.
- Research objectives
Based on the concept of early prevention, this project focuses on the role of circadian rhythms in infant sleep intervention to prevent obesity and accomplishes the following two objectives:
2.1 To determine the intensity of correlation between the daily rhythm of infants and the characteristics of melatonin secretion rhythm of gold standard.
Over mathematical modeling to establish high reliability and validity of behavioral biological clock circadian rhythm prediction model in infants and young children to verify and apply to sleep intervention multicenter cohort study.
2.2 To explore the effect of sleep intervention on infants by establishing a standard multicenter cohort of infant sleep intervention It is of great public health significance to provide high quality evidence for early prevention and control of childhood obesity and to design more pertinent prevention and control strategies.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Jiang Fan, PhD
- Phone Number: 021-38626161
- Email: fanjiang@shsmu.edu.cn
Study Locations
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Shanghai
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Shanghai, Shanghai, China, 2000127
- Shanghai children's medicial center affiliated shanghai jiaotong University School of Medicine
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Infants and young children: age 4 months, 6 months, 12 months, and 2 years old;
- term single birth (37-42 weeks of gestation);
- health inactive disease;
- normal Griffiths developmental assessment;
- natural vaginal delivery or social cesarean section;
- Apgar score greater than 7 at birth for 1 or 5 minute.
Exclusion Criteria:
- Infants and young children: birth weight < 2500 g;
- premature or multiple births;
- prenatal ultrasonography indicating intrauterine growth retardation;
- severe organic diseases of the baby after birth that have been hospitalized for treatment;
- congenital malformations or diseases affecting the feeding of the baby (cleft lip and palate, metabolic diseases, etc.).
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
No Intervention: control
Infant sleep monitoring (Actigraphy and sleep dairy) and parental surveys
|
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Experimental: Infant behavioral sleep intervention
Interventionists collaborate with the family to design a tailored sleep intervention strategy, which involves appropriate sleep schedule and bedtime routine, putting the child to bed while still sleepy rather than when already asleep, and waiting 1 to 2 minutes before attending to the child during nocturnal awakenings.
Parents are educated to implement the behavioral protocol at bedtime and subsequent night wakings.
|
The intervention consists of an infant behavioral sleep protocol.
In the tailored intervention approach, parents are asked to implement the behavioral protocol at bedtime and at subsequent night wakings.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Children's sleep condition
Time Frame: 4 months old
|
A 7-day assessment of children's sleep condition was conducted by using Actiwatch (AMI) and a sleep diary.
AMI is a sleep assessment system based on monitoring individual activity whose evaluation point is based on the sleep diary.
|
4 months old
|
Children's sleep condition
Time Frame: 6 months old
|
A 7-day assessment of children's sleep condition was conducted by using Actiwatch (AMI) and a sleep diary.
AMI is a sleep assessment system based on monitoring individual activity whose evaluation point is based on the sleep diary.
|
6 months old
|
Children's sleep condition
Time Frame: 12 months old
|
A 7-day assessment of children's sleep condition was conducted by using Actiwatch (AMI) and a sleep diary.
AMI is a sleep assessment system based on monitoring individual activity whose evaluation point is based on the sleep diary.
|
12 months old
|
Children's sleep condition
Time Frame: 2 years old
|
A 7-day assessment of children's sleep condition was conducted by using Actiwatch (AMI) and a sleep diary.
AMI is a sleep assessment system based on monitoring individual activity whose evaluation point is based on the sleep diary.
|
2 years old
|
Children's anthropometrics
Time Frame: 4 months old
|
Weight in kilograms
|
4 months old
|
Children's anthropometrics
Time Frame: 6 months old
|
Weight in kilograms
|
6 months old
|
Children's anthropometrics
Time Frame: 12 months old
|
Weight in kilograms
|
12 months old
|
Children's anthropometrics
Time Frame: 2 years old
|
Weight in kilograms
|
2 years old
|
Children's anthropometrics
Time Frame: 4 months old
|
Length/height in centimeters
|
4 months old
|
Children's anthropometrics
Time Frame: 6 months old
|
Length/height in centimeters
|
6 months old
|
Children's anthropometrics
Time Frame: 12 months old
|
Length/height in centimeters
|
12 months old
|
Children's anthropometrics
Time Frame: 2 years old
|
Length/height in centimeters
|
2 years old
|
Children's anthropometrics
Time Frame: 4 months old
|
Weight and height will be combined to report BMI (calculated by weight divided by the square of length/height) in kg/m^2
|
4 months old
|
Children's anthropometrics
Time Frame: 6 months old
|
Weight and height will be combined to report BMI (calculated by weight divided by the square of length/height) in kg/m^2
|
6 months old
|
Children's anthropometrics
Time Frame: 12 months old
|
Weight and height will be combined to report BMI (calculated by weight divided by the square of length/height) in kg/m^2
|
12 months old
|
Children's anthropometrics
Time Frame: 2 years old
|
Weight and height will be combined to report BMI (calculated by weight divided by the square of length/height) in kg/m^2
|
2 years old
|
Children's anthropometrics
Time Frame: 6 months old
|
Arm circumference in centimeters
|
6 months old
|
Children's anthropometrics
Time Frame: 12 months old
|
Arm circumference in centimeters
|
12 months old
|
Children's anthropometrics
Time Frame: 2 years old
|
Arm circumference in centimeters
|
2 years old
|
Children's anthropometrics
Time Frame: 6 months old
|
Triceps skinfold thicknesses in centimeters
|
6 months old
|
Children's anthropometrics
Time Frame: 12 months old
|
Triceps skinfold thicknesses in centimeters
|
12 months old
|
Children's anthropometrics
Time Frame: 2 years old
|
Triceps skinfold thicknesses in centimeters
|
2 years old
|
Children's anthropometrics
Time Frame: 6 months old
|
Subscapular skinfold thicknesses in centimeters
|
6 months old
|
Children's anthropometrics
Time Frame: 12 months old
|
Subscapular skinfold thicknesses in centimeters
|
12 months old
|
Children's anthropometrics
Time Frame: 2 years old
|
Subscapular skinfold thicknesses in centimeters
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood total cholesterol level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood high-density lipoprotein level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood low-density lipoprotein level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood triglycerides level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Fasting blood glucose level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood insulin level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood ghrelin level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood leptin level
|
2 years old
|
Infant metabolism index
Time Frame: 2 years old
|
Blood adiponectin level
|
2 years old
|
Children's circadian rhythm
Time Frame: 4 months old
|
Saliva melatonin levels at 7 Time Points (09: 00, 13: 00, 17: 00, 21: 00, 01: 00, 05: 00 and 09: 00) as the gold standard for circadian rhythms of biological clocks under natural environment.
|
4 months old
|
Children's circadian rhythm
Time Frame: 6 months old
|
Saliva melatonin levels at 7 Time Points (09: 00, 13: 00, 17: 00, 21: 00, 01: 00, 05: 00 and 09: 00) as the gold standard for circadian rhythms of biological clocks under natural environment.
|
6 months old
|
Children's circadian rhythm
Time Frame: 12 months old
|
Saliva melatonin levels at 7 Time Points (09: 00, 13: 00, 17: 00, 21: 00, 01: 00, 05: 00 and 09: 00) as the gold standard for circadian rhythms of biological clocks under natural environment.
|
12 months old
|
Children's circadian rhythm
Time Frame: 2 years old
|
Saliva melatonin levels at 7 Time Points (09: 00, 13: 00, 17: 00, 21: 00, 01: 00, 05: 00 and 09: 00) as the gold standard for circadian rhythms of biological clocks under natural environment.
|
2 years old
|
Collaborators and Investigators
Investigators
- Study Chair: Jiang Fan, PhD, Shanghai children's medicial center affiliated shanghai jiaotong University School of Medicine
Publications and helpful links
General Publications
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Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SCMCIRB-Y2020006
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
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University of PennsylvaniaCompletedInsomnia | Mild Cognitive ImpairmentUnited States
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The University of Hong KongSuspendedInsomnia | PreDiabetes | Sleep DeprivationHong Kong
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Solveig MagnusdottirMenntaskolin a AkureyriEnrolling by invitationDepression | Sleep | Anxiety | ChronotypeIceland
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University of South FloridaNational Institute on Aging (NIA)CompletedCaregivers of Persons With DementiaUnited States