- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05381012
Fibromyalgia Syndrome on Patients With Chronic Migraine
The Effect of Fibromyalgia Syndrome on Female Patients With Chronic Migraine
Study Overview
Status
Conditions
Detailed Description
Patients who applied to Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Neurology, headache outpatient clinic and were diagnosed with chronic migraine according to the International Headache Society Classification (ICHD-3), after the patient's history and physical examination, will be included in the study.
Date of birth, education level, body mass index, occupation, marital status, socioeconomic status, age of onset of migraine complaints, descriptive information about migraine attacks (type (with or without aura), duration of attacks, average number of days with pain, pain severity, accompaniments) will be questioned.
In addition, if the fibromyalgia syndrome meets the diagnostic criteria, symptom duration and average body pain severity in the last 3 months will be questioned.
A total of 66 patients are planned to be included in the study. In the study, 2 groups will be formed, the first group will consist of chronic migraine patients, the second group will consist of patients with chronic migraine as well as fibromyalgia syndrome.
All patients will be evaluated for allodynia, quality of life, sleep, anxiety and depression, disability related to headache, and central sensitization. Relevant forms will be filled by patients.
Patients will be evaluated with the diagnostic criteria for fibromyalgia syndrome and if the patients meet the diagnostic criteria for fibromyalgia syndrome, the Fibromyalgia Impact Questionnaire will be applied. The patient will be evaluated by Alper Mengi in terms of fibromyalgia syndrome diagnostic criteria.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Alper Mengi, MD
- Phone Number: +90 5376510385
- Email: a_mengi22@hotmail.com
Study Locations
-
-
-
Istanbul, Turkey
- Istanbul University- Cerrahpasa
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
For patients with chronic migraine:
- Being diagnosed with chronic migraine according to the International Headache Society Classification (ICHD-3)
- Being literate
For patients with fibromyalgia syndrome:
- Diagnosed with chronic migraine according to the International Headache Society Classification (ICHD-3)
- Being literate
- Diagnosed with fibromyalgia syndrome according to the 2016 American College of Rheumatology criteria
Exclusion Criteria:
- Having another pathology that can explain their pain in the head and face region other than chronic migraine (such as sinusitis, tension-type headache, trigeminal neuralgia, drug overuse headache)
- Psychiatric disease or using psychiatric drugs
- History of serious head trauma or neurosurgical intervention
- History of infectious, chronic inflammatory disease, malignancy
- Pregnant and breastfeeding women
- History of additional neurological disease other than migraine
- Uncooperative
- Having congestive heart failure, chronic kidney failure, chronic liver disease, lung disease, uncontrolled diabetes, peripheral vascular disease
- Diagnosed with hypothyroidism or hyperthyroidism
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Chronic migraine
Patients diagnosed with chronic migraine according to the International Headache Society Classification (ICHD-3).
|
All patients will be evaluated for allodynia, quality of life, sleep, anxiety and depression, disability related to headache, and central sensitization.
|
Other: Fibromyalgia syndrome
Patients diagnosed with chronic migraine according to the International Headache Society Classification (ICHD-3), and patients with fibromyalgia syndrome .
|
All patients will be evaluated for allodynia, quality of life, sleep, anxiety and depression, disability related to headache, and central sensitization.
Patients who meet the diagnostic criteria for fibromyalgia syndrome will be evaluated with the Fibromyalgia Impact Questionnaire.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Central sensitization
Time Frame: 7 days
|
The patients will be evaluated for central sensitization with Central Sensitization Inventory.
The Central Sensitization Inventory assesses 25 health-related symptoms.
Responses are recorded about the frequency of each symptom, with a Likert scale from 0 (never) to 4 (always), resulting in a total possible score of 100.
Higher scores are associated with a higher degree of self-reported symptomology.
|
7 days
|
Headache-related disability
Time Frame: 3 months
|
The patients will be evaluated for headache-related disability with The Migraine Disability Assessment Test.
Migraine Disability Assessment scores (numerical scores represent number of days patients missed or lost productivity at work or school, as well as missed days from family/social/leisure activities, and range from little or no disability (0-5) to severe disability (>20).
|
3 months
|
The impact of headache on quality of life
Time Frame: 3 months
|
The patients will be evaluated for the impact of headache on quality of life with 6-item short-form Headache Impact Test.
This test is a patient-reported outcome measure used to measure the impact and effect of headache on the ability to function normally in daily life.
It consists of 6 questions, total scores may range from 36 to 78 and higher scores reflecting greater impact.
|
3 months
|
Allodynia
Time Frame: 7 days
|
The patients will be evaluated for allodynia with the Allodynia Symptom Checklist.
The Allodynia Symptom Checklist include 12 questions about the frequency of various allodynia symptoms in association with headache attacks.
Instead of using a dichotomous option (yes or no), the response categories are "never," "rarely," "less than half the time," and "half the time or more."
In addition, subjects can also indicate that an item "does not apply to me."
That option is used by someone who never shaved their face or someone who never wore a ponytail.
|
7 days
|
Health-Related Quality
Time Frame: 7 days
|
The patients will be evaluated for the quality of life with The Short Form-36.
This form is composed of 36 items and eight subscales to evaluate quality of life (physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, and mental health).
The scores of the subscales range between 0 and 100, and higher scores indicate higher quality of life.
|
7 days
|
Sleep quality
Time Frame: 7 days
|
The patients will be evaluated for sleep quality with the Pittsburgh Sleep Quality Index.
It contains 19 self-reported items and 5 items to be completed by a bed partner or roommate, if possible.
Scores range from 0 to 3, and are summed to obtain a global score, which ranges from 0 to 21.
Higher scores indicate greater sleep disturbance.
|
7 days
|
Anxiety and depression
Time Frame: 7 days
|
The patients will be evaluated for anxiety and depression with Hospital Anxiety and Depression Scale.
The scale is a fourteen-item scale with seven items each for anxiety and depression subscales.
Scoring for each item ranges from zero to three.
A subscale score >8 denotes anxiety or depression.
|
7 days
|
The quality of life and functional status of patients with fibromyalgia
Time Frame: 1 month
|
The quality of life and functional status of patients with fibromyalgia syndrome will be evaluated with the Fibromyalgia Impact Questionnaire.
In this scale, 10 different characteristics are measured, including physical function, well-being, inability to work, difficulty at work, pain, fatigue, morning tiredness, stiffness, anxiety, and depression.
The maximum score is 100, and increased score represents decreased functionality.
|
1 month
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Descriptive information
Time Frame: 3 months
|
Date of birth, education level, body mass index, occupation, marital status, socioeconomic status, age of onset of migraine complaints, descriptive information about migraine attacks (type (with or without aura), duration of attacks, average number of days with pain, pain severity, accompaniments) will be questioned.
In addition, if the patient meets the diagnostic criteria of fibromyalgia syndrome, symptom duration and average body pain severity in the last 3 months will be questioned.
|
3 months
|
Collaborators and Investigators
Investigators
- Study Director: Uğur Uygunoğlu, MD, Istanbul University - Cerrahpasa (IUC)
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Brain Diseases
- Central Nervous System Diseases
- Nervous System Diseases
- Pain
- Neurologic Manifestations
- Disease
- Musculoskeletal Diseases
- Rheumatic Diseases
- Muscular Diseases
- Neuromuscular Diseases
- Headache Disorders, Primary
- Syndrome
- Chronic Pain
- Fibromyalgia
- Myofascial Pain Syndromes
- Migraine Disorders
- Headache
- Headache Disorders
Other Study ID Numbers
- 26.04.2022/372690
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Headache Disorders
-
Canadian Memorial Chiropractic CollegeDr. Zaxx Co.UnknownMigraine Headache | Cervicogenic Headache | Tension-type HeadacheCanada
-
University GhentRecruitingTension-Type Headache | Cervicogenic Headache | Myofascial HeadacheBelgium
-
Real Centro Universitario Maria CristinaRecruiting
-
Brooke Army Medical CenterThe University of Queensland; The Defense and Veterans Brain Injury CenterRecruitingHeadache, Migraine | Persistent Post Traumatic Headache | Cervicogenic HeadacheUnited States
-
University Hospital, GhentRecruitingMigraine Disorders | Headache Disorders | Tension-Type Headache | Cluster Headache | TACS | Secondary Headache DisorderBelgium
-
Wei DaiInternational Headache SocietyRecruitingMigraine Disorders | Medication-overuse HeadacheChina
-
Hospital of South West JutlandCompletedMedication-overuse Headache | Secondary Headache Disorders
-
Bnai Zion Medical CenterUnknownChildren, Only | Headache, Migraine | Headache, TensionIsrael
-
VR1 CorporationTerminatedPrimary Headache DisordersUnited States
-
University of AlbertaCompletedChronic Headache | Chronic Daily Headache | Analgesic Rebound Headache | Headache, IntractableCanada
Clinical Trials on Allodynia, quality of life, sleep, anxiety and depression, disability, and central sensitization
-
Marmara UniversityCompletedFamilial Mediterranean Fever | Central SensitisationTurkey
-
Assiut UniversityCompleted
-
University Hospital, RouenNot yet recruitingIrritable Bowel SyndromeFrance
-
Gaziler Physical Medicine and Rehabilitation Education...CompletedNeuropathic PainTurkey
-
Electromedical Products International, Inc.Completed
-
Assistance Publique - Hôpitaux de ParisUnknownBehçet's Disease, neuroBehcet, Anxiety, Depression, TirednessFrance
-
Sohag UniversityNot yet recruitingPatients With Multiple SclerosisEgypt
-
Nigde Omer Halisdemir UniversityCompleted
-
Trakya UniversityCompletedQuality of Life | Rheumatoid Arthritis | Depression, Anxiety | Nurse's RoleTurkey
-
University of ChicagoActive, not recruitingCovid-19 | Critical Illness | Respiratory Failure | Corona Virus InfectionUnited States