- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05442333
Adjuvant Versus Neo-adjuvant Radiotherapy in Patients With Resectable Soft Tissue Sarcoma in Extremities : Wound Complications
Study Overview
Status
Intervention / Treatment
Detailed Description
Study Tools :The patients will be managed as follows:
Primary (Preoperative) Diagnosis and Evaluation
Clinical Evaluation. History. General examination. Local examination.
Radiological Evaluation:
Plain X-ray for the affected limb to determine presence of any bone affection or invasion.
Preoperative MRI scan to determine the extent of soft tissue, bone and neurovascular bundle invasion.
Preoperative bone scan to determine skeletal metastatic load.
Perioperative protocol:
Preoperative radiotherapy 3-6 weeks before surgical excision. Postoperative radiotherapy 3- 6 weeks or more after surgical excision Tissue diagnosis will be obtained.
Operative management:
Surgical excision of whole tumour with wide safety margin.
Data collection:
Patient demographics (age, sex). Activity level Primary sarcoma type Patient comorbidities Timing of Preoperative radiotherapy if present. Timing of Postoperative radiotherapy if present. Time from diagnosis to surgery. recurrence Operative time (minutes) measured from skin incision to wound closure. Follow up regarding wound complications, local recurrence or infection. local recurrence will be followed up till the end of the study
Follow up strategy:
The patients with preoperative radiotherapy:
will be assessed 2 weeks postoperative regarding wound signs of infection (redness, hotness or discharge).
1 month postoperatively for wound complete closure and exclude signs of infection.
3 months postoperatively for wound dehiscence, swelling or local recurrence. 6 months postoperatively for local recurrence, pathological fractures or joint stiffness
The patients with postoperative radiotherapy:
will be assessed 3 weeks post radiation regarding wound signs of infection (redness, hotness or discharge).
6 weeks post radiation for wound dehiscence 3 months post radiation for local swelling or recurrence 6 months post radiation for local recurrence, joint stiffness or pathological fractures.
Statistical Analysis: Statistical package for social science (SPSS 15.0.1 for windows ; 〖SPSS Inc,Chicago,IL,2001). Data will be presented as Mean and Standard deviation ( +/-SD) for quantitative parametric data , and Median and Interquartile range for quantitative non parametric data. Frequency and percentage will be used for presenting qualitative data. Suitable analysis will be done according to the type of data obtained. P<0.05 will be considered significant.
Statistical Package: data entry and statistical analysis of the collected data will be performed using reliable software program.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Cairo, Egypt, 02
- Ain Shams University Hospitals
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Sex: both sexes.
- Lesion: any soft tissue sarcoma in upper or lower limbs (synovial sarcoma, liposarcoma, fibrosarcoma and others)
- age more than 16 years old
Exclusion Criteria:
- Irresectable ESTS
- Round cell ESTS
- recurrent ESTS
- patients who received local irradiation due to other causes
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: preoperative radiotherapy
The patients which will receive preoperative radiotherapy
|
• The patients with preoperative radiotherapy:
The patients with postoperative radiotherapy:
Other Names:
|
Active Comparator: postoperative radiotherapy
The patients which will receive postoperative radiotherapy
|
• The patients with preoperative radiotherapy:
The patients with postoperative radiotherapy:
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
wound and local complications
Time Frame: 12 months
|
12 months
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
recurrence rate
Time Frame: 2 years
|
2 years
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ziad khaled
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Sharing Time Frame
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Resectable Soft Tissue Sarcoma
-
Institut BergoniéNovartis; Chugai Pharma FranceRecruitingResectable | Non-metastatic Soft-tissue SarcomaFrance
-
Centre Leon BerardRecruitingSoft Tissue Sarcoma | Resectable Soft Tissue Sarcoma | Adult Soft Tissue SarcomaFrance
-
Mayo ClinicNational Cancer Institute (NCI)RecruitingSoft Tissue Sarcoma | Recurrent Soft Tissue Sarcoma | Resectable Soft Tissue SarcomaUnited States
-
Mayo ClinicNational Cancer Institute (NCI)Active, not recruitingStage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Resectable Soft Tissue Sarcoma | Stage I Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IB Soft Tissue Sarcoma of the Trunk and Extremities...United States
-
National Cancer Institute (NCI)NRG OncologyActive, not recruitingSoft Tissue Sarcoma | Resectable Soft Tissue SarcomaUnited States
-
Institut BergoniéIncyte Biosciences International SàrlRecruitingResectable SarcomaFrance
-
M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Not yet recruitingMetastatic Sarcoma | Resectable Sarcoma | Recurrent SarcomaUnited States
-
Roswell Park Cancer InstituteRecruitingColorectal Cancer | Metastatic Unresectable Sarcoma | Metastatic Malignant Neoplasm in the Lung | Resectable Sarcoma | Metastatic Soft Tissue Sarcoma | Metastatic Bone SarcomaUnited States
-
M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingStage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IIIA Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IIIB Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Resectable... and other conditionsUnited States
-
OHSU Knight Cancer InstituteNational Cancer Institute (NCI)WithdrawnStage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Stage II Adult Soft Tissue Sarcoma | Stage IIA Adult Soft Tissue Sarcoma | Stage IIB Adult Soft Tissue Sarcoma | Stage IIC Adult Soft Tissue Sarcoma
Clinical Trials on surgical resection with safety margin
-
Samsung Medical CenterNational Cancer Center, Korea; Asan Medical Center; Seoul National University... and other collaboratorsRecruitingSurgery | Tongue Cancer | Squamous Cell Carcinoma | Resection Margin | Tongue Cancer TNM Staging Primary Tumor (T) T1 | Tongue Cancer TNM Staging Primary Tumor (T) T2Korea, Republic of
-
Eastern Hepatobiliary Surgery HospitalUnknownHepatocellular CarcinomaChina
-
Mansoura UniversityRecruiting
-
Pusan National University HospitalUnknownLung Cancer | Surgery | Effects of Chemotherapy | Cancer of Lymph NodeKorea, Republic of
-
Qazvin University Of Medical SciencesUnknownOral Lichen PlanusIran, Islamic Republic of
-
Makerere UniversityCompletedSurgical Safety Checklist Compliance | Perioperative Surgical Adverse Events
-
The Hospital for Sick ChildrenInstitute for Clinical Evaluative SciencesCompletedPostoperative Complications | Intraoperative ComplicationsCanada
-
Region SkaneEnrolling by invitationCancer of Lung | Cancer of Prostate | Lung MetastasisSweden
-
Cairo UniversityCompleted
-
Sixth Affiliated Hospital, Sun Yat-sen UniversityFirst Affiliated Hospital, Sun Yat-Sen UniversityRecruitingEndoscopic Recurrence Rate | After Ileocolic Crohn 's Disease SurgeryChina