- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05508243
Dermatological Assessment of Primary Dermal Irritability Accumulated and Sensitization of Hyaluronic Nasal Spray
March 15, 2023 updated by: Herbarium Laboratorio Botanico Ltda
Dermatologist-supervised Assessment of Primary and Accumulated Irritation Potential and Skin Sensitization Potential for the NASAL SPRAY Product
Evaluate the potential of Primary Dermal Irritability, Accumulated Dermal Irritability and Dermal Sensitization, of health products through the application of Patch Test, proving the safety of the product for topical use.
The study will be conducted with a Brazilian sample in which 65 research participants will be included.
Depending on the results, the present study may support the claim: dermatologically tested.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
65
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
SP
-
Campinas, SP, Brazil, 13041-315
- Kosmoscience Ciência e Tecnologia Cosmética Ltda
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 70 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Healthy research participant
- Age range between 18 and 70 years.
- Gender: female and male.
- Phototype (Fitzpatrick): I to IV.
- Agree to adhere to the requirements of the study in the fight against the COVID-19 pandemic, through preventive measures: use a mask according to WHO guidelines; use the mask while traveling to the research center and during the study procedures; maintain social distancing; wash hands frequently with soap and/or alcohol gel and go to the research center only at scheduled times to avoid agglomerations.
- Agree not to wet the site during the entire test period;
- Understand the test procedures and agree to their adherence to the study requirements;
- Absence of inflammatory dermatoses or tattoo at the application site;
- Signing of the Free and Informed Consent Term (FICT).
Exclusion Criteria:
- Pregnancy, lactation;
- Participants with hyperthermia (body temperature greater than or equal to 37.5ºC);
- Participants who have been diagnosed with COVID-19 by RT-PCR exam or by the presence of IgM antibodies in the serology exam, in the last 4 weeks or who are presenting the following symptoms: dry or productive cough, sneezing, runny nose, body pain , headache, anosmia (loss of smell), ageusia (loss of taste) and/or any other symptom that may be related to covid-19 at the discretion of the investigator;
- Participant who belongs to the risk group for COVID-19, that is, with cardiovascular, renal and chronic respiratory problems, immunosuppressed or other conditions that the doctor judges as belonging to the risk group;
- Participants with heart disease (eg, but not limited to: atrial fibrillation, obstructive coronary artery disease);
- Participants with renal and/or neurological diseases;
- Participants with severe or decompensated lung and/or respiratory diseases;
- Use of corticosteroids, antihistamines and/or anti-inflammatory drugs;
- Presence of localized or generalized skin diseases;
- Presence of active inflammatory dermatoses in the test region;
- Frequent exposure to the sun or tanning beds;
- Have participated in an allergenicity study within a period of less than four weeks from the beginning of the study;
- Research participants with a history of allergy to the material used in the study;
- Atopy history;
- History of pathologies aggravated or triggered by ultraviolet radiation;
- Immunodeficiency carriers;
- Forecast of intense sun exposure or tanning session during the study period;
- Forecast to take a bath in the sea, swimming pool or sauna during the study;
- Research participants who practice water sports;
- Research participants with dermographism;
- Use of the following topical or systemic medications: immunosuppressants, antihistamines, non-steroidal anti-inflammatory drugs, and corticosteroids up to 2 weeks before selection;
- Treatment with acidic vitamin A and/or its derivatives orally or topically up to 1 month before the start of the study;
- Aesthetic and/or dermatological body treatment up to 03 weeks before selection;
- Vaccination forecast during the study or up to 03 weeks before the study;
- Any condition not mentioned above that, in the opinion of the investigator, could compromise the evaluation of the study;
- History of non-adherence or unwillingness to adhere to the study protocol;
- Professionals directly involved in carrying out this protocol and their families.
- Be participating in some other study at the moment.
- Any condition that, in the opinion of the researcher, could compromise the study.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Other
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Experimental
|
Health care product - nasal application
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Absence
Time Frame: 6 weeks
|
Absence occurence of phototoxicity and photoallergy
|
6 weeks
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 17, 2022
Primary Completion (Actual)
November 24, 2022
Study Completion (Actual)
November 24, 2022
Study Registration Dates
First Submitted
August 18, 2022
First Submitted That Met QC Criteria
August 18, 2022
First Posted (Actual)
August 19, 2022
Study Record Updates
Last Update Posted (Actual)
March 17, 2023
Last Update Submitted That Met QC Criteria
March 15, 2023
Last Verified
March 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HB053-22
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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