- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05640687
The Study of Mesenchymal Stem Cells Treat Autoimmune Pulmonary Alveolar Proteinosis in Vitro
March 20, 2023 updated by: ShiYue Li, Guangzhou Institute of Respiratory Disease
The Study of Mesenchymal Stem Cells Treat Autoimmune Pulmonary Alveolar in Vitro
Autoimmune pulmonary alveolar proteinosis (aPAP) is a respiratory disease characterized by massive deposition of pulmonary surfactant in the alveoli, involving a variety of immune cells and factor disorders.
However, there are certain limits in treatment at present.
MSCs can improve the microenvironment in the alveoli by regulating immunity, thereby achieving a good therapeutic effect.
The purpose of this study is to use the lavage fluid obtained after whole lung lavage with aPAP to isolate alveolar macrophages, and to use MSC to complete the verification of the efficacy of aPAP primary alveolar macrophages in vitro.
A series of protocols including multi-factor detection, cell phenotype analysis and phagocytosis assay were used to evaluate the efficacy of MSCs on alveolar macrophages.
Study Overview
Status
Active, not recruiting
Conditions
Study Type
Observational
Enrollment (Actual)
26
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Guangdong
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Guangzhou, Guangdong, China, 510120
- Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 75 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
This project recruited clinical patients who met the criteria for inclusion and exclusion from patients diagnosed with aPAP in the First Affiliated Hospital of Guangzhou Medical University.
Description
Inclusion Criteria:
- Sign an informed consent form before any research-related activities;
- No gender restrictions, age ≥18 years old, and ≤75 years old;
Patients who need to receive whole lung lavage due to the needs of the disease, and the patient agrees to perform whole lung lavage. The standards are as follows:
- The diagnosis of aPAP is clear, and the anti-GM-CSF antibody in serum is greater than 5 μg/ml;
- PaO2 <65 mmHg;
- P(A-a)O2>40 mmHg;
- Intrapulmonary shunt >10%-12%.
Exclusion Criteria:
- Suffering from multiple chronic respiratory diseases at the same time, including but not limited to chronic obstructive pulmonary disease, pulmonary fibrosis, and asthma;
- Various malignant tumors or a history of malignant tumors;
- Uncontrolled pulmonary or systemic infection;
- Severe other systemic diseases: acute myocardial infarction, unstable angina pectoris, liver cirrhosis, acute glomerulonephritis, etc.;
- Syphilis, HIV, HCV antibody positive;
- Patients with coagulation disorders who cannot perform bronchoscopy, such as hemophilia, giant platelet syndrome, thrombocytopenia, etc.;
- Severe renal impairment, serum creatinine > 1.5 times the upper limit of normal;
- Liver disease or liver function damage: ALT, AST, total bilirubin > 2 times the upper limit of normal;
- Have any coexisting medical conditions or diseases that the investigators judge may impair the development of this trial;
- Social and mental disability, no legal capacity/limited capacity;
Refuse to sign the informed consent.
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Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
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aPAP
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healthy control
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Genomics
Time Frame: 2022.12.31-2023.03.01
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2022.12.31-2023.03.01
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
March 1, 2021
Primary Completion (Actual)
February 1, 2023
Study Completion (Anticipated)
April 6, 2023
Study Registration Dates
First Submitted
November 28, 2022
First Submitted That Met QC Criteria
November 28, 2022
First Posted (Actual)
December 7, 2022
Study Record Updates
Last Update Posted (Actual)
March 21, 2023
Last Update Submitted That Met QC Criteria
March 20, 2023
Last Verified
November 1, 2022
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2020132
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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